WormBase Tree Display for Variation: WBVar00242511

WBVar00242511 Evidence: Paper_evidence: WBPaper00005807
  Name: Public_name: sa191
    Other_name: Y116F11B.1.1:c.109C>T
      CE25720:p.Arg37Cys
      Y116F11B.1.2:c.109C>T
    HGVSg: CHROMOSOME_V:g.19815553C>T
  Sequence_details: SMap: S_parent: Sequence: Y116F11B
    Flanking_sequences: gccaacttcaaggccgagggcccactaagc gtgcagtccgtgttccaggtgtggccgtga
    Mapping_target: Y116F11B
    Type_of_mutation: Substitution: c t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00022782
    Laboratory: JT
    Status: Live
  Affects: Gene: WBGene00000920
    Transcript: Y116F11B.1.2 (12)
      Y116F11B.1.1 (12)
    Interactor: WBInteraction000500208
      WBInteraction000500209
      WBInteraction000500211
      WBInteraction000500212
      WBInteraction000500213
      WBInteraction000500214
      WBInteraction000500215
      WBInteraction000501854
      WBInteraction000504688
      WBInteraction000520855
  Genetics: Interpolated_map_position: V 23.5302
    Mapping_data: In_multi_point: 2825
      In_pos_neg_data: 7416
  Description: Phenotype: WBPhenotype:0000012 Paper_evidence: WBPaper00001923
          WBPaper00044570
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson2292
        Remark: Some low level Dauer formation at 15C (8.1%)(n=533), 99% Dauer formation at 25C (n=418). ozDf2/+ animals are not Daf-c; all sa191/ozDf2 are Daf-c; 10% sa191/+ are Daf-c. Paper_evidence: WBPaper00001923
            Curator_confirmed: WBPerson712
          constitutive dauer formation; dauer larvae resume development within 2 hours, even at 25C. Semidominant: 10% of sa191/+ animals form dauers. Probable gf mutation. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Paper_evidence: WBPaper00001923
          Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00001923
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Paper_evidence: WBPaper00001923
              Curator_confirmed: WBPerson712
              Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000306 Paper_evidence: WBPaper00038115
        Curator_confirmed: WBPerson712
        Remark: Levels of trx-1 are increased significantly more than that observed in wild type dauer larvae as assayed by the average relative intensity of fluorescence of ofEx379[Ptrx-1::GFP; Pelt-2::mCherry]. Paper_evidence: WBPaper00038115
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000032 PATO:0000460 Paper_evidence: WBPaper00038115
                Curator_confirmed: WBPerson712
      WBPhenotype:0000308 Paper_evidence: WBPaper00001923
        Curator_confirmed: WBPerson712
        Remark: Dauers recover within 2 hrs, even at 25C. Paper_evidence: WBPaper00001923
            Curator_confirmed: WBPerson712
      WBPhenotype:0000964 Paper_evidence: WBPaper00037649
        Curator_confirmed: WBPerson712
        Remark: partially resistant Paper_evidence: WBPaper00037649
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0002212 Paper_evidence: WBPaper00001923
        Curator_confirmed: WBPerson712
  Reference: WBPaper00038115
    WBPaper00021929
    WBPaper00002485
    WBPaper00001923
    WBPaper00037649
    WBPaper00012298
    WBPaper00014659
    WBPaper00044570
  Method: Substitution_allele