WormBase Tree Display for Variation: WBVar00241266

WBVar00241266 Evidence: Paper_evidence: WBPaper00036073
  Name: Public_name: qm162
    Other_name: CE37947:p.Cys67Tyr
      ZK637.9.1:c.200G>A
    HGVSg: CHROMOSOME_III:g.8912403G>A
  Sequence_details: SMap: S_parent: Sequence: ZK637
    Flanking_sequences: agagtttcgtcgaatggcctcatattatct cggagatttcgattcaataaataaacagat
    Mapping_target: ZK637
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00024553
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026666
    Laboratory: MQ
    Status: Live
  Affects: Gene: WBGene00014027
    Transcript: ZK637.9.1 (12)
    Interactor: WBInteraction000517496
  Genetics: Interpolated_map_position: III 0.0102613
    Mapping_data: In_multi_point: 5435
  Description: Phenotype: WBPhenotype:0000042 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00036073
                Curator_confirmed: WBPerson712
      WBPhenotype:0000061 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
      WBPhenotype:0000154 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
      WBPhenotype:0000207 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: slow defecation Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0000463 Paper_evidence: WBPaper00041750
        Curator_confirmed: WBPerson2987
        Remark: tpk-1(qm162) mutants were found to produce several metabolite compounds in significantly altered amounts relative to wild-type worms (Figure 3). Paper_evidence: WBPaper00041750
            Curator_confirmed: WBPerson2987
      WBPhenotype:0000641 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Clk mutants had a longer period of mobility than wild-type worms. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0000674 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000022 PATO:0000460 Paper_evidence: WBPaper00036073
                Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0002163 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Measurement of whole-worm oxygen consumption in day 1 adult worms revealed that Clk mutants showed decreased oxygen consumption compared to wild-type worms. | Like control animals, the Clk mutants show a decrease in oxygen consumption from day 1 to day 7. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000112 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Mutants failed to show any increase in SOD-2 and levels of SOD-1 were unchanged. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0001574 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: ATP levels are normal despite decreased mitochondrial function. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0001621 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: At 0.2 mm paraquat, worms developed as well as wild-type worms. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004938 Paper_evidence: WBPaper00036073
              Curator_confirmed: WBPerson712
            WBMol:00002747 Paper_evidence: WBPaper00036073
              Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
  Reference: WBPaper00041750
    WBPaper00036073
  Method: Substitution_allele