WormBase Tree Display for Variation: WBVar00241246

WBVar00241246 Name: Public_name: qm38
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026640
      WBStrain00026646
      WBStrain00026647
      WBStrain00026648
    Laboratory: MQ
    Status: Live
  Affects: Gene: WBGene00000538
    Interactor: WBInteraction000517494
  Description: Phenotype: WBPhenotype:0000031 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slow growth, phenotypes similar to Clk-1; profound maternal and zygotic rescue Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000043 Paper_evidence: WBPaper00003496
        Curator_confirmed: WBPerson712
        Remark: Mutants develop more slowly than N2. Paper_evidence: WBPaper00003496
            Curator_confirmed: WBPerson712
      WBPhenotype:0000061 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0000154 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0000208 Paper_evidence: WBPaper00031896
        Curator_confirmed: WBPerson712
        Remark: The defecation mean cycle time was increased about 40% above the defecation cycle of wild-type animals. Paper_evidence: WBPaper00031896
            Curator_confirmed: WBPerson712
      WBPhenotype:0000277 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slow rhythms, phenotypes similar to Clk-1; profound maternal and zygotic rescue Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000641 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0001621 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Worms are more sensitive to oxidative stress than wild-type worms. | At 0.2 mM paraquat, worms showed early developmental arrest in response to oxidative stress. | Worms all showed developmental deficits compared to N2 worms. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004938 Paper_evidence: WBPaper00036073
              Curator_confirmed: WBPerson712
            WBMol:00002747 Paper_evidence: WBPaper00036073
              Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0002163 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Measurement of whole-worm oxygen consumption in day 1 adult worms revealed that clk-3 mutants did not show decreased oxygen consumption compared to wild-type worms | Unike control animals, the Clk mutants did not show a decrease in oxygen consumption from day 1 to day 7. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000062 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: no lethality Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000246 Paper_evidence: WBPaper00031896
        Curator_confirmed: WBPerson712
        Remark: Although animals exhibited an extended mean time between execution of the defecation motor program, the variance between DMP activation was not significantly different from wild-type. Paper_evidence: WBPaper00031896
            Curator_confirmed: WBPerson712
      WBPhenotype:0001574 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: ATP levels are normal despite decreased mitochondrial function. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
  Reference: WBPaper00015392
    WBPaper00011038
    WBPaper00003496
    WBPaper00017925
    WBPaper00036073
    WBPaper00031896
  Method: Allele