WormBase Tree Display for Variation: WBVar00241210

WBVar00241210 Name: Public_name: qa4900
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040625
    Laboratory: XA
    Status: Live
  Affects: Gene: WBGene00004361
  Description: Phenotype: WBPhenotype:0000039 Paper_evidence: WBPaper00005733
        Curator_confirmed: WBPerson712
        Remark: Life span of maternally rescued animals is shortened; animals die around 10 days old whereas N2 survive past 30 days. Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00005733
                Curator_confirmed: WBPerson712
      WBPhenotype:0000047 Paper_evidence: WBPaper00005733
        Curator_confirmed: WBPerson712
        Remark: Arrest in early embryogenesis likely occurs during gastrulation based on the number of DAPI-positive nuclei an the deve Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000010 PATO:0000460 Paper_evidence: WBPaper00005733
                Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
      WBPhenotype:0000231 Paper_evidence: WBPaper00005733
        Curator_confirmed: WBPerson712
        Remark: Maternally rescued adults are increased in body width. Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00005733
                Curator_confirmed: WBPerson712
      WBPhenotype:0000463 Paper_evidence: WBPaper00005733
        Curator_confirmed: WBPerson712
        Remark: Heparan sulfate was reduced in maternally rescued animals based on the presence of only faint Toluidine blue staining in the pharyngeal region versus prominent staining in wild-type worms. Also, heparan sulfate GAG disaccharides as analyzed by HPLC are reduced wherease chondroitin GAG disaccharides showed no change in levels compared to wild-type levels. Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00005733
                Curator_confirmed: WBPerson712
      WBPhenotype:0000640 Paper_evidence: WBPaper00005733
        Curator_confirmed: WBPerson712
        Remark: Maternally rescued adults are Egl. Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00005733
                Curator_confirmed: WBPerson712
      WBPhenotype:0000641 Paper_evidence: WBPaper00005733
        Curator_confirmed: WBPerson712
        Remark: Maternally rescued homozygous mutants exhibit reduced movement. Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00005733
                Curator_confirmed: WBPerson712
      WBPhenotype:0000676 Paper_evidence: WBPaper00005733
        Curator_confirmed: WBPerson712
        Remark: Maternally rescued animals exhibit delayed growth in body length and area. Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
      WBPhenotype:0000707 Paper_evidence: WBPaper00031153
        Curator_confirmed: WBPerson712
        Remark: The isthmus fails to elongate during the late stages of pharyngeal morphogenesis in embryogenesis. Paper_evidence: WBPaper00031153
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0003734 PATO:0000460 Paper_evidence: WBPaper00031153
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000021 PATO:0000460 Paper_evidence: WBPaper00031153
                Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00031153
            Curator_confirmed: WBPerson712
      WBPhenotype:0000867 Paper_evidence: WBPaper00005733
        Curator_confirmed: WBPerson712
        Remark: Majority of embryos arrest early (93.1% n=607), escapers arrest at 2- or 3-fold (2.6%), shortly after hatching (3.1%) or are dead (1.2%). Animals that make it to hatching often have morphological defects such as a notched head. Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00005733
                Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00005733
            Curator_confirmed: WBPerson712
      WBPhenotype:0001345 Paper_evidence: WBPaper00031153
        Curator_confirmed: WBPerson712
        Remark: Both actin and intermediate filaments were disorganized and exhibited other abnormalities in their arrangement and shape in the pharyngeal isthmus. Actin filaments were detected by phalloidin staining. Intermediate filaments were detected by both MH4 antibody staining and a GFP-tagged IF protein. Paper_evidence: WBPaper00031153
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0003734 PATO:0000460 Paper_evidence: WBPaper00031153
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000021 PATO:0000460 Paper_evidence: WBPaper00031153
                Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00031153
            Curator_confirmed: WBPerson712
  Reference: WBPaper00031153
    WBPaper00005733
  Method: Allele