WormBase Tree Display for Variation: WBVar00240993

WBVar00240993 Evidence: Paper_evidence: WBPaper00001677
  Name: Public_name: q50
    Other_name: CE00237:p.Cys126Ser
      F02A9.6.1:c.376T>A
    HGVSg: CHROMOSOME_III:g.9094707T>A
  Sequence_details: SMap: S_parent: Sequence: F02A9
    Flanking_sequences: tcgggagtaaatccatgcgattcggatcct gcaacaacggactctgctatccattctatg
    Mapping_target: F02A9
    Type_of_mutation: Substitution: t a Paper_evidence: WBPaper00001677
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: JK
    Status: Live
  Affects: Gene: WBGene00001609
    Transcript: F02A9.6.1 (12)
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: III 0.162787
  Description: Phenotype: WBPhenotype:0000286 Paper_evidence: WBPaper00001007
        Curator_confirmed: WBPerson2021
        Remark: Although signs of pharyngeal differentiation is seen within the embryo, morphogenesis is defective, and a recognizable worm is not made. Paper_evidence: WBPaper00001007
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001007
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001007
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001007
                Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001007
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000684 Paper_evidence: WBPaper00001007
        Curator_confirmed: WBPerson2021
        Remark: Only 6-21 germ cells are produced in glp-1 mutants. All these germ cells differentiate into sperm Paper_evidence: WBPaper00001007
            Curator_confirmed: WBPerson2021
        Penetrance: High: Paper_evidence: WBPaper00001007
              Curator_confirmed: WBPerson2021
          Range: 84 84 Paper_evidence: WBPaper00001007
                Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001007
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001007
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00001007
                Curator_confirmed: WBPerson2021
            WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00001007
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000823 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: weaker phenotype than q46, some oocyte production, fertilized eggs arrest during embryogenesis) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000867 Paper_evidence: WBPaper00001007
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: fertilized eggs arrest during embryogenesis Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001007
          Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00001007
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001007
                Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001007
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00001007
  Method: Substitution_allele