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WormBase Tree Display for Variation: WBVar00146344

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Name Class

WBVar00146344EvidencePaper_evidenceWBPaper00003653
WBPaper00042557
NamePublic_namegm122
Other_nameC01G6.8b.1:c.757C>T
C01G6.8a.1:c.835C>T
CE39126:p.Gln120Ter
C01G6.8c.1:c.358C>T
C01G6.8c.2:c.358C>T
CE24774:p.Gln253Ter
CE32563:p.Gln279Ter
HGVSgCHROMOSOME_II:g.9298616G>A
Sequence_detailsSMapS_parentSequenceC01G6
Flanking_sequencestataaagtttgcgaatcggattctaacaataaattgtttcgatttgcaagcacgattgtg
Mapping_targetC01G6
Type_of_mutationSubstitutionct
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00028753
WBStrain00035434
WBStrain00035438
WBStrain00035439
WBStrain00055653
LaboratoryNG
StatusLive
AffectsGeneWBGene00000289
TranscriptC01G6.8c.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScC01G6.8c.1:c.358C>T
HGVSpCE39126:p.Gln120Ter
cDNA_position461
CDS_position358
Protein_position120
Exon_number3/8
Codon_changeCaa/Taa
Amino_acid_changeQ/*
C01G6.8b.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScC01G6.8b.1:c.757C>T
HGVSpCE24774:p.Gln253Ter
cDNA_position789
CDS_position757
Protein_position253
Exon_number5/10
Codon_changeCaa/Taa
Amino_acid_changeQ/*
C01G6.8c.2VEP_consequencestop_gained
VEP_impactHIGH
HGVScC01G6.8c.2:c.358C>T
HGVSpCE39126:p.Gln120Ter
cDNA_position363
CDS_position358
Protein_position120
Exon_number2/7
Codon_changeCaa/Taa
Amino_acid_changeQ/*
C01G6.8a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScC01G6.8a.1:c.835C>T
HGVSpCE32563:p.Gln279Ter
cDNA_position838
CDS_position835
Protein_position279
Exon_number6/11
Codon_changeCaa/Taa
Amino_acid_changeQ/*
Interactor (53)
GeneticsInterpolated_map_positionII1.10234
DescriptionPhenotype (16)
Phenotype_not_observedWBPhenotype:0000218Paper_evidenceWBPaper00031110
Curator_confirmedWBPerson712
RemarkNo significant number of overinduced animals (worms with greater than three VPCs induced) were detected.Paper_evidenceWBPaper00031110
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00031110
Curator_confirmedWBPerson712
WBPhenotype:0000219Paper_evidenceWBPaper00031110
Curator_confirmedWBPerson712
RemarkNo underinduced animals (worms with fewer than 22 vulval cells or fewer than three VPCs induced) were detected.Paper_evidenceWBPaper00031110
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00031110
Curator_confirmedWBPerson712
WBPhenotype:0000306Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Remark"Wild-type animals or cam-1 mutants that carry mab-5::gfp expressed high levels of GFP in QL descendants but not in QR descendants (Figure 5; Table 2)."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004993PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBbt:0004086PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayGenotypemuIs16 [mab-5::GFP]Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0000406Paper_evidenceWBPaper00002978
Curator_confirmedWBPerson557
WBPhenotype:0000469Paper_evidenceWBPaper00006269
WBPaper00024898
Curator_confirmedWBPerson2987
Remark"In cam-1(gm122) mutants, the QL descendants usually migrate to their proper positions (Fig. 4B)... To further investigate the role in Q cell migration of CAM-1 domains, we assessed the position of Q cell descendants in cam-1(sa692) and cam-1(ks52) (Fig. 5, Table 1). The final positions of QL descendants were similar in all three cam-1 mutants to wild type, suggesting that CAM-1 is not required for proper QL migration."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Table 1, Figure 6Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004993PATO:0000460Paper_evidenceWBPaper00006269
WBPaper00024898
Curator_confirmedWBPerson2987
WBbt:0004086PATO:0000460Paper_evidenceWBPaper00006269
WBPaper00024898
Curator_confirmedWBPerson2987
WBbt:0004056PATO:0000460Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00006269
WBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatment"The percentage of QL cell descendants that were not located posterior to V4.p is presented. These represent QL descendants that have migrated anteriorly, rather than posteriorly. Because they occupy positions near each other, the data for SDQL and PVM were combined."Paper_evidenceWBPaper00006269
Curator_confirmedWBPerson2987
From Table 1 legend: "Because QL descendants sometimes were misplaced anteriorly and at other times were misplaced posteriorly, we present the data for both phenotypes. A QL cell descendant was scored as misplaced anteriorly if its nucleus was anterior to V4.p and misplaced posteriorly if its nucleus was posterior to V5.p. Because they occupy positions near each other, the data for SDQL and PVM were combined."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0000700Paper_evidenceWBPaper00002978
Curator_confirmedWBPerson557
WBPhenotype:0001652Paper_evidenceWBPaper00032446
Curator_confirmedWBPerson2021
WBPhenotype:0002193Paper_evidenceWBPaper00057191
Curator_confirmedWBPerson712
Remark0% n=54Paper_evidenceWBPaper00057191
Curator_confirmedWBPerson712
ImageWBPicture0000014918Paper_evidenceWBPaper00057191
Curator_confirmedWBPerson712
Reference (11)
MethodSubstitution_allele