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WormBase Tree Display for Variation: WBVar00146316

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Name Class

WBVar00146316EvidencePaper_evidenceWBPaper00003027
NamePublic_namegm33
Other_nameF55C7.7a.1:c.1006-6A>G
F55C7.7i.2:c.1006-6A>G
F55C7.7i.1:c.1006-6A>G
F55C7.7b.1:c.1006-6A>G
HGVSgCHROMOSOME_I:g.4026947T>C
Sequence_detailsSMapS_parentSequenceC09D1
Flanking_sequencesgtgatgtatagacaatttctggtttttttaaacagggtatggaagtgtctgtgaaacaag
Mapping_targetC09D1
Type_of_mutationSubstitutionagPaper_evidenceWBPaper00003027
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00028731
LaboratoryNG
StatusLive
AffectsGeneWBGene00006805
TranscriptF55C7.7i.1VEP_consequencesplice_region_variant,intron_variant
VEP_impactLOW
HGVScF55C7.7i.1:c.1006-6A>G
Intron_number6/25
F55C7.7b.1VEP_consequencesplice_region_variant,intron_variant
VEP_impactLOW
HGVScF55C7.7b.1:c.1006-6A>G
Intron_number6/20
F55C7.7a.1VEP_consequencesplice_region_variant,intron_variant
VEP_impactLOW
HGVScF55C7.7a.1:c.1006-6A>G
Intron_number7/33
F55C7.7i.2VEP_consequencesplice_region_variant,intron_variant
VEP_impactLOW
HGVScF55C7.7i.2:c.1006-6A>G
Intron_number6/24
InteractorWBInteraction000538757
WBInteraction000538762
IsolationMutagenEMS
GeneticsInterpolated_map_positionI-1.84382
DescriptionPhenotypeWBPhenotype:0000104Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
Remark"Mutations in unc-73 also blocked the Q migrations and disrupted the polarized leading processes (Fig. 3I-M). In animals carrying the weak unc-73 allele e936, 6% of the QL cells were unpolarized and 9% of the QR cells were unpolarized. In animals containing the stronger unc-73 allele, gm33, 24% of QL cells and 26% of QR cells were unpolarized."Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004056PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
WBbt:0004054PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
GO_termGO:0030010PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
WBPhenotype:0000425Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
RemarkMutant animals exhibited reduced or lost expression of MAB-5 protein in QL descendants, as determined by antibody staining (Figure 6E)Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0007274PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
WBbt:0007276PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
WBPhenotype:0001404Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
RemarkMutant animals exhibited ectopic expression of MAB-5 protein in QR descendants, as determined by antibody staining (Figure 6E)Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0007279PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
WBbt:0007281PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
ReferenceWBPaper00003027
WBPaper00004437
MethodSubstitution_allele