Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00145460

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00145460NamePublic_namegk3
Other_nameZC101.2d.1:c.9937+27_11850-6del
ZC101.2e.1:c.7837+27_9750-6del
ZC101.2g.1:c.340+27_2253-6del
HGVSgCHROMOSOME_II:g.14647863_14650567del
Sequence_detailsSMapS_parentSequenceC38C6
Flanking_sequencescgcagctccaccaccaagttcgtagctgaattaacgagaaaaaaaaattcacttacgtct
Mapping_targetC38C6
Type_of_mutationDeletion
PCR_productgk3_external
gk3_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005889
LaboratoryVC
PersonWBPerson427
KO_consortium_allele
StatusLive
AffectsGeneWBGene00006787
TranscriptZC101.2e.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScZC101.2e.1:c.7837+27_9750-6del
Intron_number26-34/34
Exon_number27-34/35
ZC101.2d.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScZC101.2d.1:c.9937+27_11850-6del
Intron_number36-44/45
Exon_number37-44/46
ZC101.2g.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScZC101.2g.1:c.340+27_2253-6del
Intron_number2-10/10
Exon_number3-10/11
InteractorWBInteraction000538528
IsolationMutagenformaldehyde
DescriptionPhenotype_not_observedWBPhenotype:0000195Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Remark"The unc-52(ra515) and unc-52(gk3) alleles result from deletions of exons 15 through 18 encoding four Domain IV Ig repeats, or exons 28 through 37 encoding the C-terminal Domain V of UNC-52, respectively (Mullen et al., 1999)... DTC migrations are normal in these strains, and the frequency of DTC migration defects in double mutants of unc-52(ra515); unc-5(e152) and unc-52(gk3); unc-5(e152) are not significantly different from unc-5(e152) alone (P > 0.1; Table 1)."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006865PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
WBPhenotype:0000643Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Remark"The unc-52(ra515) and unc-52(gk3) alleles result from deletions of exons 15 through 18 encoding four Domain IV Ig repeats, or exons 28 through 37 encoding the C-terminal Domain V of UNC-52, respectively (Mullen et al., 1999). Neither of these alleles exhibits the severe Unc or gonadal rupture phenotypes of the class I viable unc-52 alleles."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
WBPhenotype:0000691Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Remark"The unc-52(ra515) and unc-52(gk3) alleles result from deletions of exons 15 through 18 encoding four Domain IV Ig repeats, or exons 28 through 37 encoding the C-terminal Domain V of UNC-52, respectively (Mullen et al., 1999). Neither of these alleles exhibits the severe Unc or gonadal rupture phenotypes of the class I viable unc-52 alleles."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
ReferenceWBPaper00017850
WBPaper00025979
WBPaper00005809
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele