WormBase Tree Display for Variation: WBVar00145253
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WBVar00145253 | Name | Public_name | ev574 | ||||||
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Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Laboratory | NW | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00003111 | |||||||
Interactor | WBInteraction000535986 | ||||||||
WBInteraction000535987 | |||||||||
WBInteraction000535990 | |||||||||
WBInteraction000535994 | |||||||||
WBInteraction000535995 | |||||||||
WBInteraction000556037 | |||||||||
Description | Phenotype | WBPhenotype:0000050 | Paper_evidence | WBPaper00040551 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Mutants of vab-1 and mab-20 are known to affect ventral pocket closure [6,8] . Many vab-1 null mutant [vab-1(0)] embryos fail to close the open ventral pocket before embryo elongation begins [8,13] . The residual hole in the mutant epidermis provides a conduit for the extrusion of internal blast cells from the embryo, thereby causing lethality (Figure S2A)... Despite more severe (Figures S3A-S3D) and eight times more penetrant midline alignment defects in the mab-20 null (Figure 5; Figures S3A-S3D; Table S2), the penetrance of lethality among mab-20(0) embryos is significantly lower than for vab-1(0) embryos (Figure 5C)." | Paper_evidence | WBPaper00040551 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Penetrance | Incomplete | 19 | Paper_evidence | WBPaper00040551 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00040551 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000384 | Paper_evidence | WBPaper00049274 | |||||||
Curator_confirmed | WBPerson850 | ||||||||
Remark | SDQL axon guidance is defective | Paper_evidence | WBPaper00049274 | ||||||
Curator_confirmed | WBPerson850 | ||||||||
WBPhenotype:0000594 | Paper_evidence | WBPaper00040551 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Two of five mab-20(0) embryos exhibited a detectable skewing of the P cell leading edges from the D/V body wall axis as they migrate toward the midline (Figure 1D, 370' inset), not observed in the wild-type (n = 20). In contrast to vab-1 mutants, none of the mab-20 embryos showed a significant delay in either the onset or the rate of P cell migration (n = 5). For this reason we suggest that P cell misalignment in mab-20 and plx-2 mutants is caused by a defect in P cell polarity or guidance, or abnormal adhesions of P cell leading tips, but not by a defect in P cell progression toward the midline." | Paper_evidence | WBPaper00040551 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0008115 | PATO:0000460 | Paper_evidence | WBPaper00040551 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00040551 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0001227 | Paper_evidence | WBPaper00027335 | |||||||
Curator_confirmed | WBPerson48 | ||||||||
Remark | Ray commissure: R1. | Paper_evidence | WBPaper00027335 | ||||||
Curator_confirmed | WBPerson48 | ||||||||
Penetrance | Incomplete | Paper_evidence | WBPaper00027335 | ||||||
Curator_confirmed | WBPerson48 | ||||||||
Range | 6 | 6 | Paper_evidence | WBPaper00027335 | |||||
Curator_confirmed | WBPerson48 | ||||||||
WBPhenotype:0001908 | Paper_evidence | WBPaper00040551 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Mutants of vab-1 and mab-20 are known to affect ventral pocket closure [6,8]. Many vab-1 null mutant [vab-1(0)] embryos fail to close the open ventral pocket before embryo elongation begins [8,13] . The residual hole in the mutant epidermis provides a conduit for the extrusion of internal blast cells from the embryo, thereby causing lethality (Figure S2A)." | Paper_evidence | WBPaper00040551 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00040551 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0002403 | Paper_evidence | WBPaper00040551 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "The penetrance of mab-20 and plx-2 null mutant P cell midline alignment defects are 86% and 8%, respectively (Figure 5A; Table S2). mab-20(0) and plx-2(0) embryos do not have obvious open pocket defects, yet mab-20(0) embryos extrude internal cells from the ventral side [6] suggesting that severe P cell alignment defects weaken the midline, causing it to rupture when circumferential constrictive forces of embryo elongation occur." see also Figure S3C | Paper_evidence | WBPaper00040551 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Penetrance | High | 86 | Paper_evidence | WBPaper00040551 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0008115 | PATO:0001654 | Paper_evidence | WBPaper00040551 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00040551 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0002404 | Paper_evidence | WBPaper00040551 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "All plexin band cells (i.e, bridge plus scaffold cells) are present in roughly normal positions in the vab-1 plx-2 double null mutant embryos. However, time-lapse analysis shows that double mutant embryos unexpectedly have narrow gaps between sister plexin band cells (hereafter referred to as sister cell gaps) that are not present in the vab-1 null or the wild-type (see Figure 2D, 340') in addition to the gaps between nonsister plexin band cells that are found in 97% of vab-1 null embryos. The gaps between sister plexin band cells in the vab-1 plx-2 double null are not as severe as in the mab-20; vab-1 double null because the former have some aggregates of sister cells that are absent in the latter (data not shown). These results suggest that PLX-2 and MAB-20 have redundant functions with VAB-1 in forming or maintaining adhesions between sister plexin band cells, just as they have redundant functions with VAB-1 in preventing embryonic lethality." | Paper_evidence | WBPaper00040551 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
EQ_annotations | Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00040551 | ||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_assay | Genotype | vab-1(dx31) | Paper_evidence | WBPaper00040551 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_not_observed | WBPhenotype:0001652 | Paper_evidence | WBPaper00032446 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Reference | WBPaper00040551 | ||||||||
WBPaper00032446 | |||||||||
WBPaper00027335 | |||||||||
WBPaper00018347 | |||||||||
WBPaper00018341 | |||||||||
WBPaper00049274 | |||||||||
Method | Allele |