WormBase Tree Display for Variation: WBVar00145130
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| WBVar00145130 | Evidence | Paper_evidence | WBPaper00033119 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Public_name | ek1 | |||||||
| Sequence_details | SeqStatus | Pending_curation | |||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain | WBStrain00007239 | ||||||||
| Laboratory | ET | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00000837 | |||||||
| Interactor | WBInteraction000009243 | ||||||||
| WBInteraction000009244 | |||||||||
| WBInteraction000009245 | |||||||||
| WBInteraction000009246 | |||||||||
| WBInteraction000009251 | |||||||||
| WBInteraction000009252 | |||||||||
| WBInteraction000502741 | |||||||||
| WBInteraction000502914 | |||||||||
| WBInteraction000503983 | |||||||||
| Genetics | Mapping_data | In_multi_point | 4243 | ||||||
| Description | Phenotype | WBPhenotype:0000119 | Paper_evidence | WBPaper00033119 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | cul-2 mutation resulted in higher MEL-26 levels in 16/24 embryos in meiosis I. As cul-2 embryos proceed from meiosis I to meiosis II, there was an increase in the proportion of embryos with high levels of MEL-26 staining compared to wild-type | Paper_evidence | WBPaper00033119 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00033119 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00033119 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Treatment | MEL-26 antibody staining | Paper_evidence | WBPaper00033119 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| WBPhenotype:0001645 | Paper_evidence | WBPaper00033119 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | Both meiotic and mitotic MEI-1 levels appeared higher in cul-2 mutants than corresponding wild-type embryos, consistent with cul-2(+) being required for efficient MEI-1 degradation | Paper_evidence | WBPaper00033119 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00033119 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00033119 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Treatment | MEI-1 antibody staining | Paper_evidence | WBPaper00033119 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_not_observed | WBPhenotype:0000120 | Paper_evidence | WBPaper00033119 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | Meiotic MEI-1 staining in cul-2 mutant embryos did not decrease | Paper_evidence | WBPaper00033119 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Null | Paper_evidence | WBPaper00033119 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| EQ_annotations | Life_stage | WBls:0000003 | PATO:0000460 | Paper_evidence | WBPaper00033119 | ||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Treatment | MEI-1 antibody staining | Paper_evidence | WBPaper00033119 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Reference | WBPaper00033119 | ||||||||
| Method | Allele |
