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WormBase Tree Display for Variation: WBVar00145005

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Name Class

WBVar00145005EvidencePaper_evidenceWBPaper00026735
WBPaper00028877
NamePublic_namee2800
Other_nameZK678.8.1:c.952C>T
CE40491:p.His318Tyr
HGVSgCHROMOSOME_X:g.15758090G>A
Sequence_detailsSMapS_parentSequenceZK678
Flanking_sequencesaagcactcatttgacgactttgttgtttatattatcagtattcgaggcactcggcgaaat
Mapping_targetZK678
Type_of_mutationSubstitutionct
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004675
LaboratoryCB
StatusLive
AffectsGeneWBGene00044630
TranscriptZK678.8.1 (12)
IsolationMutagenEMS
GeneticsInterpolated_map_positionX22.9588
DescriptionPhenotypeWBPhenotype:0000010Person_evidenceWBPerson261
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
Variation_effectLoss_of_function_undetermined_extentPerson_evidenceWBPerson261
Curator_confirmedWBPerson48
WBPhenotype:0000031Paper_evidenceWBPaper00037686
Curator_confirmedWBPerson712
RemarkAnimals exhibited markedly slower larval growth than wild type. Generation time was ~15 hours longer than for wild type animals.Paper_evidenceWBPaper00037686
Curator_confirmedWBPerson712
WBPhenotype:0000229Paper_evidenceWBPaper00037686
Curator_confirmedWBPerson712
RemarkAnimals were notably smaller than wild type in mature adult body size.Paper_evidenceWBPaper00037686
Curator_confirmedWBPerson712
WBPhenotype:0000586Person_evidenceWBPerson261
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
Variation_effectLoss_of_function_undetermined_extentPerson_evidenceWBPerson261
Curator_confirmedWBPerson48
WBPhenotype:0001012Paper_evidenceWBPaper00037686
Curator_confirmedWBPerson712
RemarkAnimals are able to crawl fairly efficiently across bands of CBX120 (Bacillus pumilus) bacteria growth (hurdles). By contrast, wild type worms move through these bands with great difficulty.Paper_evidenceWBPaper00037686
Curator_confirmedWBPerson712
WBPhenotype:0001014Person_evidenceWBPerson261
Curator_confirmedWBPerson48
RemarkResistant to M. nematophilum.Person_evidenceWBPerson261
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
Variation_effectLoss_of_function_undetermined_extentPerson_evidenceWBPerson261
Curator_confirmedWBPerson48
WBPhenotype:0001209Paper_evidenceWBPaper00026735
Person_evidenceWBPerson261
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
Variation_effectLoss_of_function_undetermined_extentPerson_evidenceWBPerson261
Curator_confirmedWBPerson48
WBPhenotype:0001212Paper_evidenceWBPaper00026735
Curator_confirmedWBPerson48
RemarkVery strongly more fragile than wild type, based on a comparison of bleach sensitivity.Paper_evidenceWBPaper00026735
Curator_confirmedWBPerson48
WBPhenotype:0001411Paper_evidenceWBPaper00026735
Person_evidenceWBPerson261
Curator_confirmedWBPerson48
RemarkLectin staining abnormal.Person_evidenceWBPerson261
Curator_confirmedWBPerson48
Based on lectin binding properties to the cuticlePaper_evidenceWBPaper00026735
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson261
Curator_confirmedWBPerson48
Variation_effectLoss_of_function_undetermined_extentPerson_evidenceWBPerson261
Curator_confirmedWBPerson48
Phenotype_assayTreatmentTested the following fluorescein or rhodamine-conjugated lectins: WGA, SBA, TPA, PEA,, CON, LEA.Paper_evidenceWBPaper00026735
Curator_confirmedWBPerson48
WBPhenotype:0001413Paper_evidenceWBPaper00026735
Curator_confirmedWBPerson48
WBPhenotype:0001416Paper_evidenceWBPaper00026735
Curator_confirmedWBPerson48
RemarkBased on vital dye staining for bacteria to reveal M. nematophilum; no rectal staining, indicating no adherence in the usual region.Paper_evidenceWBPaper00026735
Curator_confirmedWBPerson48
WBPhenotype:0001418Paper_evidenceWBPaper00026735
Curator_confirmedWBPerson48
WBPhenotype:0001420Paper_evidenceWBPaper00031925
Curator_confirmedWBPerson712
RemarkAnimals are completely resistant to attachment of biofilm produced by Xenorhabdus nematophila.Paper_evidenceWBPaper00031925
Curator_confirmedWBPerson712
PenetranceCompletePaper_evidenceWBPaper00031925
Curator_confirmedWBPerson712
Phenotype_assayTreatmentBiofilm formation on adult worms was assessed for worms incubated 24-48 hours on the bacterial lawn. Alternatively, gravid adults were allowed to lay eggs on bacterial lawns for several hours, then removed and larvae were assessed for biofilm attachment the next day.Paper_evidenceWBPaper00031925
Curator_confirmedWBPerson712
WBPhenotype:0001918Paper_evidenceWBPaper00052991
Curator_confirmedWBPerson38714
WBPhenotype:0002159Paper_evidenceWBPaper00045395
Curator_confirmedWBPerson499
WBPhenotype:0002354Paper_evidenceWBPaper00045395
Curator_confirmedWBPerson499
WBPhenotype:0002462Paper_evidenceWBPaper00045395
Curator_confirmedWBPerson499
Remarkincreased fungal spore adhesionPaper_evidenceWBPaper00045395
Curator_confirmedWBPerson499
WBPhenotype:0004006Paper_evidenceWBPaper00037686
Curator_confirmedWBPerson712
RemarkHermaphrodites experienced significantly reduced contact times by males during mating.Paper_evidenceWBPaper00037686
Curator_confirmedWBPerson712
ReferenceWBPaper00026735
WBPaper00031925
WBPaper00037686
WBPaper00052991
WBPaper00045395
MethodSubstitution_allele