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WormBase Tree Display for Variation: WBVar00144863

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Name Class

WBVar00144863NamePublic_namee2519
Other_namee2519mat
ZC395.2.1:c.442G>A
CE01438:p.Glu148Lys
HGVSgCHROMOSOME_III:g.5278926G>A
Sequence_detailsSMapS_parentSequenceZC395
Flanking_sequencesctgaaaattctcacaagattacgtgatgagagcttcatcatcatgatactggagtagaac
Mapping_targetZC395
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004607
WBStrain00026641
WBStrain00026663
WBStrain00026675
WBStrain00026678
WBStrain00026679
WBStrain00026680
WBStrain00026681
LaboratoryCB
StatusLive
AffectsGeneWBGene00000536
TranscriptZC395.2.1 (12)
InteractorWBInteraction000008544
WBInteraction000008545
WBInteraction000051700
WBInteraction000504935
WBInteraction000520617
WBInteraction000524898
WBInteraction000524899
GeneticsInterpolated_map_positionIII-1.8467
Mapping_dataIn_multi_point2741
2744
2755
3304
DescriptionPhenotype (15)
Phenotype_not_observedWBPhenotype:0001068Paper_evidenceWBPaper00031241
Curator_confirmedWBPerson712
RemarkPre-exposure to mianserin blocked serotonin-induced egg laying as it does in N2.Paper_evidenceWBPaper00031241
Curator_confirmedWBPerson712
Phenotype_assayTreatmentPre-exposure to 50uM mianserin.Paper_evidenceWBPaper00031241
Curator_confirmedWBPerson712
WBPhenotype:0001653Paper_evidenceWBPaper00026674
Curator_confirmedWBPerson2987
RemarkTable 3Paper_evidenceWBPaper00026674
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003022Paper_evidenceWBPaper00026674
Curator_confirmedWBPerson2987
WBPhenotype:0001775Paper_evidenceWBPaper00031942
Curator_confirmedWBPerson712
RemarkLike wild-type, growth under thermocycling conditions of 10 minute shifts between 12C and 25C, resulted in a shift in life span more similar to the extended life span of animals reared at 12.5C continuously.Paper_evidenceWBPaper00031942
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown in microfuge tubes in 100l S medium (maintained) and incubated in thermocyclers. Worms were transferred into autoclaved, sterile microfuge tubes either every other day or once every 3 days, dependent upon the strain and stage of life of the worms used. Worms were monitored, counted and fed on a daily basis. Animals were shifted every 10 minutes between 12C and 25C.Paper_evidenceWBPaper00031942
Curator_confirmedWBPerson712
Temperature12, 12.5, 18.5, 25Paper_evidenceWBPaper00031942
Curator_confirmedWBPerson712
WBPhenotype:0001789Paper_evidenceWBPaper00031942
Curator_confirmedWBPerson712
RemarkAnimals displayed basically the same overall pattern as observed with wild-type animals in that animals were short lived at 25C and long lived at 12.5C.Paper_evidenceWBPaper00031942
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown in microfuge tubes in 100l S medium (maintained) and incubated in thermocyclers. Worms were transferred into autoclaved, sterile microfuge tubes either every other day or once every 3 days, dependent upon the strain and stage of life of the worms used. Worms were monitored, counted and fed on a daily basis. Animals were shifted every 10 minutes between 12C and 25C.Paper_evidenceWBPaper00031942
Curator_confirmedWBPerson712
Temperature12, 12.5, 18.5, 25Paper_evidenceWBPaper00031942
Curator_confirmedWBPerson712
WBPhenotype:0001991Paper_evidenceWBPaper00034694
Curator_confirmedWBPerson2857
Remarkanimals enter into hypoxia-induced reproductive and developmental diapause same as wild-typePaper_evidenceWBPaper00034694
Curator_confirmedWBPerson2857
Reference (28)
MethodSubstitution_allele