WormBase Tree Display for Variation: WBVar00144808

WBVar00144808 Evidence: Paper_evidence: WBPaper00004884
  Name: Public_name: e2400
    Other_name: ZC395.6.1:c.827_835delinsGC
      CE30119:p.Met276SerfsTer34
    HGVSg: CHROMOSOME_III:g.5266308_5266316delinsGC
  Sequence_details: SMap: S_parent: Sequence: ZC395
    Flanking_sequences: agtacataaatcacagcaaatatggtgtca ttggtcttaaagaattcgttccatggctca
    Mapping_target: ZC395
    Type_of_mutation: Insertion: GC
      Deletion
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004566
      WBStrain00026646
      WBStrain00026651
      WBStrain00026665
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00001740
    Transcript: ZC395.6.1 VEP_consequence: frameshift_variant
        VEP_impact: HIGH
        HGVSc: ZC395.6.1:c.827_835delinsGC
        HGVSp: CE30119:p.Met276SerfsTer34
        cDNA_position: 850-858
        CDS_position: 827-835
        Protein_position: 276-279
        Exon_number: 6/11
        Codon_change: aTGCAATGTAtt/aGCtt
        Amino_acid_change: MQCI/SX
    Interactor: WBInteraction000517499
  Genetics: Interpolated_map_position: III -1.8507
    Mapping_data: In_multi_point: 1634
        2740
        3304
  Description: Phenotype: WBPhenotype:0000043 Paper_evidence: WBPaper00003496
        Curator_confirmed: WBPerson712
        Remark: Mutants develop more slowly than N2. Paper_evidence: WBPaper00003496
            Curator_confirmed: WBPerson712
      WBPhenotype:0000061 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Some increase in life-span; complete maternal rescue. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000119 Paper_evidence: WBPaper00036073
        Curator_confirmed: WBPerson712
        Remark: Animals exhibited a significant increase in SOD-1 and SOD-2 expression. Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Paper_evidence: WBPaper00036073
            Curator_confirmed: WBPerson712
      WBPhenotype:0000402 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Tends to avoid bacterial lawn; complete maternal rescue. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000676 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Postembryonic growth rate greatly reduced. Complete maternal rescue. Impossible to score (ES0) during zygotic stage. Difficult to score (ES2) at other stages. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES2_Difficult_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001273 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Increased resistance to heat-shock; complete maternal rescue. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
  Reference: WBPaper00027283
    WBPaper00015392
    WBPaper00003496
    WBPaper00017925
    WBPaper00036073
    WBPaper00021761
    WBPaper00022484
    WBPaper00020820
  Remark: e2400 is a small rearrangement starting at nucleotide 2720 of ZC395 (the sequence TGCAATGTA is replaced by GC and resulting in a frameshift [030408 ck1]
  Method: Deletion_and_insertion_allele