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WormBase Tree Display for Variation: WBVar00144593

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WBVar00144593	Evidence	Paper_evidence	WBPaper00001677
	Name	Public_name	e2144
		Other_name	F02A9.6.1:c.2785C>T
			CE00237:p.Leu929Phe
		HGVSg	CHROMOSOME_III:g.9098178C>T
	Sequence_details	SMap	S_parent	Sequence	F02A9
		Flanking_sequences	tcaaagtatagacgacgagttctgcactgg	ttgctgccaatgtcagaggaaaaccggaag
		Mapping_target	F02A9
		Type_of_mutation	Substitution	c	t	Paper_evidence	WBPaper00001677
		SeqStatus	Sequenced
	Variation_type	Allele
	Origin	Species	Caenorhabditis elegans
		Strain	WBStrain00004881
			WBStrain00007730
		Laboratory	CB
			CF
		Status	Live
	Affects	Gene	WBGene00001609
		Transcript	F02A9.6.1 (12)
		Interactor	WBInteraction000521908
			WBInteraction000521912
			WBInteraction000521921
			WBInteraction000521924
			WBInteraction000557985
			WBInteraction000557987
	Isolation	Mutagen	EMS
	Genetics	Interpolated_map_position	III	0.163947
		Mapping_data	In_multi_point	2462
	Description	Phenotype	WBPhenotype:0000050	Paper_evidence	WBPaper00001008
					WBPaper00040544
				Curator_confirmed	WBPerson2021
					WBPerson712
				Remark	The end of temperature sensitive period for the Emb phenotype is near the 28 cell stage	Paper_evidence	WBPaper00001008
						Curator_confirmed	WBPerson2021
					temperature-sensitive mutation that causes embryonic lethality at its restrictive temperature	Paper_evidence	WBPaper00040544
						Curator_confirmed	WBPerson712
				Penetrance	Complete	At 25C, 100 percent of mutants are Emb	Paper_evidence	WBPaper00001008
							Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001008
					Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000003	PATO:0000460	Paper_evidence	WBPaper00001008
								Curator_confirmed	WBPerson2021
				Temperature_sensitive	Heat_sensitive	25	Paper_evidence	WBPaper00001008
							Curator_confirmed	WBPerson2021
							Paper_evidence	WBPaper00040544
							Curator_confirmed	WBPerson712
				Maternal	Strictly_maternal	Paper_evidence	WBPaper00001008
						Curator_confirmed	WBPerson2021
				Phenotype_assay	Temperature	15C , 25C	Paper_evidence	WBPaper00001008
							Curator_confirmed	WBPerson2021
			WBPhenotype:0000052	Person_evidence	WBPerson261
				Curator_confirmed	WBPerson712
				Temperature_sensitive	Heat_sensitive	25	Person_evidence	WBPerson261
							Curator_confirmed	WBPerson712
				Maternal	With_maternal_effect	Person_evidence	WBPerson261
						Curator_confirmed	WBPerson712
			WBPhenotype:0000216	Paper_evidence	WBPaper00003363
				Curator_confirmed	WBPerson712
				Remark	pes-1::lacZ expression is eliminated completely.	Paper_evidence	WBPaper00003363
						Curator_confirmed	WBPerson712
			WBPhenotype:0000684	Paper_evidence	WBPaper00001008
				Curator_confirmed	WBPerson2021
				Remark	At 25C, gonads of glp-1 mutants contain only 5-15 cells that resemble sperm and no other germ cells.	Paper_evidence	WBPaper00001008
						Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001008
					Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000041	PATO:0000460	Paper_evidence	WBPaper00001008
								Curator_confirmed	WBPerson2021
				Temperature_sensitive	Heat_sensitive	25	Paper_evidence	WBPaper00001008
							Curator_confirmed	WBPerson2021
				Phenotype_assay	Temperature	15C , 25C	Paper_evidence	WBPaper00001008
							Curator_confirmed	WBPerson2021
			WBPhenotype:0000688	Paper_evidence	WBPaper00001008
					WBPaper00040544
				Curator_confirmed	WBPerson2021
					WBPerson712
				Remark	Animals become sterile adults when shifted to 25C as L2 larvae	Paper_evidence	WBPaper00001008
						Curator_confirmed	WBPerson2021
				Penetrance	Complete	At 25C, 100 percent of mutants are sterile	Paper_evidence	WBPaper00001008
							Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001008
					Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000041	PATO:0000460	Paper_evidence	WBPaper00001008
								Curator_confirmed	WBPerson2021
				Temperature_sensitive	Heat_sensitive	25	Paper_evidence	WBPaper00001008
							Curator_confirmed	WBPerson2021
							Paper_evidence	WBPaper00040544
							Curator_confirmed	WBPerson712
				Phenotype_assay	Temperature	15C , 25C	Paper_evidence	WBPaper00001008
							Curator_confirmed	WBPerson2021
			WBPhenotype:0000812	Paper_evidence	WBPaper00031962
				Curator_confirmed	WBPerson712
				Remark	Animals are devoid of germ cells.	Paper_evidence	WBPaper00031962
						Curator_confirmed	WBPerson712
				Variation_effect	Probable_null_via_phenotype	Paper_evidence	WBPaper00031962
						Curator_confirmed	WBPerson712
				Temperature_sensitive	Heat_sensitive	25	Paper_evidence	WBPaper00031962
							Curator_confirmed	WBPerson712
				Phenotype_assay	Temperature	25	Paper_evidence	WBPaper00031962
							Curator_confirmed	WBPerson712
			WBPhenotype:0001759	Paper_evidence	WBPaper00031962
				Curator_confirmed	WBPerson712
				Remark	21UR-1 was absent from animals at the restrictive temperature, which are devoid of germ cells.	Paper_evidence	WBPaper00031962
						Curator_confirmed	WBPerson712
				Variation_effect	Probable_null_via_phenotype	Paper_evidence	WBPaper00031962
						Curator_confirmed	WBPerson712
				EQ_annotations	GO_term	GO:0034585	PATO:0000460	Paper_evidence	WBPaper00031962
								Curator_confirmed	WBPerson712
				Temperature_sensitive	Heat_sensitive	25	Paper_evidence	WBPaper00031962
							Curator_confirmed	WBPerson712
				Phenotype_assay	Temperature	25	Paper_evidence	WBPaper00031962
							Curator_confirmed	WBPerson712
	Reference (11)
	Method	Substitution_allele