WormBase Tree Display for Variation: WBVar00144541

WBVar00144541 Evidence: Paper_evidence: WBPaper00001677
  Name: Public_name: e2072
    Other_name: F02A9.6.1:c.410G>A
      CE00237:p.Gly137Glu
    HGVSg: CHROMOSOME_III:g.9094741G>A
  Sequence_details: SMap: S_parent: Sequence: F02A9
    Flanking_sequences: acaacggactctgctatccattctatggtg atttcagtgcatatgcaacaatggatatgg
    Mapping_target: F02A9
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00001677
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00022555
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00001609
    Transcript: F02A9.6.1 (12)
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: III 0.162813
  Description: Phenotype: WBPhenotype:0000035 Paper_evidence: WBPaper00001008
        Curator_confirmed: WBPerson2021
        Remark: glp-1 larvae develop prominent surface lumps Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001008
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
            WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 20C Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000052 Paper_evidence: WBPaper00001008
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: Mel, late embryonic arrest, no AB derived pharyngeal cells, variable hypodermal defects Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Penetrance: Complete: 100 percent Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001008
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 15C , 25C Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000080 Paper_evidence: WBPaper00001008
        Curator_confirmed: WBPerson2021
        Remark: glp-1 mutants have a partial pharynx as indicated by their morphology as well as antibody staining to IFA (a marginal cell marker) and pharyngeal specific myosin Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001008
          Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003681 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
            WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: antibody staining with 9.2.1 (anti-pharyngeal specific myosin) and anti-IFA Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
          Temperature: 20C Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000097 Paper_evidence: WBPaper00001008
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: In glp-1 embryos, AB blastomere most likely produces extra neurons instead of pharyngeal cells Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
          no AB derived pharyngeal cells, variable hypodermal defects Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00001008
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
            WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20C Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000189 Paper_evidence: WBPaper00001008
        Curator_confirmed: WBPerson2021
        Remark: Hypodermis fails to subdivide into distinct dorsal, lateral, and ventral rows of cells Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001008
          Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005733 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 20C Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000216 Paper_evidence: WBPaper00003363
        Curator_confirmed: WBPerson712
        Remark: pes-1::lacZ expression is eliminated in the ABa lineage but remains normal in ABp. Paper_evidence: WBPaper00003363
            Curator_confirmed: WBPerson712
      WBPhenotype:0000242 Paper_evidence: WBPaper00001008
        Curator_confirmed: WBPerson2021
        Remark: Many glp-1 embryos do not elongate Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Penetrance: Low: 20 percent Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001008
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 20C Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000703 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: variable hypodermal defects Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000779 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: late embryonic arrest, no AB derived pharyngeal cells, variable hypodermal defects Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Maternal: With_maternal_effect: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000961 Paper_evidence: WBPaper00003363
        Curator_confirmed: WBPerson712
        Remark: pes-1::lacZ expression is eliminated in the ABa lineage but remains normal in ABp. Paper_evidence: WBPaper00003363
            Curator_confirmed: WBPerson712
      WBPhenotype:0001643 Paper_evidence: WBPaper00001008
        Curator_confirmed: WBPerson2021
        Remark: glp-1 embryos have super-numerary hypodermal cells Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Penetrance: Complete: 100 percent Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001008
          Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0005733 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: antibody staining with MH27 (which recognizes the apical junction complexes around each hypodermal cell) Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
          Temperature: 20C Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001646 Paper_evidence: WBPaper00001008
        Curator_confirmed: WBPerson2021
        Remark: No pharyngeal cells are made under certain experimental conditions (See treatment for details) Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Penetrance: Complete: 100 percent Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00001008
          Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003681 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
          Life_stage: WBls:0000009 PATO:0000460 Paper_evidence: WBPaper00001008
                Curator_confirmed: WBPerson2021
        Maternal: Strictly_maternal: Paper_evidence: WBPaper00001008
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: The pharyngeal precursors MSaa and MSpa were laser-ablated and the resulting embryos were stained with 9.2.1 (anti-pharyngeal specific myosin) Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
          Temperature: 20C Paper_evidence: WBPaper00001008
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00027246
    WBPaper00003363
    WBPaper00001008
    WBPaper00016588
    WBPaper00016490
  Method: Substitution_allele