WormBase Tree Display for Variation: WBVar00144465
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WBVar00144465 | Name | Public_name | e1996 | ||||||
---|---|---|---|---|---|---|---|---|---|
Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00004511 | ||||||||
WBStrain00022640 | |||||||||
Laboratory | CB | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00001413 | |||||||
Interactor | WBInteraction000500323 | ||||||||
WBInteraction000502810 | |||||||||
WBInteraction000520223 | |||||||||
WBInteraction000521256 | |||||||||
WBInteraction000521711 | |||||||||
WBInteraction000524763 | |||||||||
WBInteraction000524774 | |||||||||
WBInteraction000524790 | |||||||||
WBInteraction000576794 | |||||||||
Genetics | Mapping_data | In_multi_point | 899 | ||||||
1264 | |||||||||
1266 | |||||||||
1766 | |||||||||
1909 | |||||||||
1910 | |||||||||
2287 | |||||||||
3129 | |||||||||
In_pos_neg_data | 959 | ||||||||
964 | |||||||||
972 | |||||||||
Description | Phenotype | WBPhenotype:0000436 | Paper_evidence | WBPaper00035521 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | In fem-3(lf) X0 female germ lines, the progression of RAD-51 focus formation and removal was similar to N2 X0 males where RAD-51 foci were shifted to later meiotic prophase substages and overall levels were higher. | We observed HIM-3 on the single X chromosome in pachytene nuclei in the male germ line as well as in fem-3(lf) germ lines. Furthermore, in the fem-3(lf) X0 mutant HIM-3 was maintained on the single X in diakinesis as in N2 XX hermaphrodites. | HTP-1, HTP-2, and HTP-3 were loaded onto both the paired Xs and the single X.| SYP-1 was not loaded on the single X of N2 males; however, 30% of fem-3(lf) X chromosomes had SYP-1 staining. | Paper_evidence | WBPaper00035521 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000687 (11) | |||||||||
WBPhenotype:0000730 | Paper_evidence | WBPaper00035521 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | X0 germ lines are competent for physiological apoptosis as shown by the low levels of apoptotic bodies seen in control worms. | Analysis of apoptosis in X0 germ lines revealed low levels of basal apoptosis, even though they have anasynapsed X. | Paper_evidence | WBPaper00035521 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000741 | Paper_evidence | WBPaper00035521 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001024 | Paper_evidence | WBPaper00000922 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Few XO animals lacking only maternal fem-3 show vulval differentiation. | Paper_evidence | WBPaper00000922 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Penetrance | Low | Paper_evidence | WBPaper00000922 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Range | 7 | 7 | Paper_evidence | WBPaper00000922 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
Recessive | Paper_evidence | WBPaper00000922 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00000922 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00000922 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Maternal | |||||||||
WBPhenotype:0001348 | Paper_evidence | WBPaper00035521 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | In fem-3(lf) X0 germ lines, the H3dimethylK9 foci remained intense until diakinesis, although there was some redistribution of the mark in diplotene. In N2 and him-8 hermaphrodites, this intense focus is redistributed throughout the genome in the transition from pachytene to diplotene; in N2 male germ lines, H3dimethylK9 persisted on the single X chromosome until the transition to spermatocytes. | Paper_evidence | WBPaper00035521 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001357 | Paper_evidence | WBPaper00000922 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | XO animals lacking only maternal fem-3 have abnormal gonads | Paper_evidence | WBPaper00000922 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Penetrance | Incomplete | Paper_evidence | WBPaper00000922 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
Range | 31 | 31 | Paper_evidence | WBPaper00000922 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
Recessive | Paper_evidence | WBPaper00000922 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Variation_effect | Null | Paper_evidence | WBPaper00000922 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00000922 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Maternal | |||||||||
WBPhenotype:0001824 | Paper_evidence | WBPaper00035521 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Meiotic prophase timing in these X0 mutants was slow (54-60 hr), similar to N2 XX hermaphrodites. Progression of labeled nuclei through each prophase substage similarly paralleled N2 XX hermaphrodites. | Paper_evidence | WBPaper00035521 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_not_observed | WBPhenotype:0000061 | Paper_evidence | WBPaper00001837 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Lifespans of animals were normal. | Paper_evidence | WBPaper00001837 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000717 | Paper_evidence | WBPaper00035521 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | In the germ lines of both N2 X0 males and fem-3(lf) X0 females transcription of two X-linked oocyte-enriched genes, which are activated in late pachytene in hermaphrodites, was not activated. | Paper_evidence | WBPaper00035521 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Reference | WBPaper00035521 | ||||||||
WBPaper00001837 | |||||||||
WBPaper00022032 | |||||||||
WBPaper00016316 | |||||||||
WBPaper00000922 | |||||||||
WBPaper00013845 | |||||||||
WBPaper00012610 | |||||||||
Method | Allele |