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WormBase Tree Display for Variation: WBVar00144465

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Name Class

WBVar00144465NamePublic_namee1996
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004511
WBStrain00022640
LaboratoryCB
StatusLive
AffectsGeneWBGene00001413
InteractorWBInteraction000500323
WBInteraction000502810
WBInteraction000520223
WBInteraction000521256
WBInteraction000521711
WBInteraction000524763
WBInteraction000524774
WBInteraction000524790
WBInteraction000576794
GeneticsMapping_dataIn_multi_point899
1264
1266
1766
1909
1910
2287
3129
In_pos_neg_data959
964
972
DescriptionPhenotypeWBPhenotype:0000436Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
RemarkIn fem-3(lf) X0 female germ lines, the progression of RAD-51 focus formation and removal was similar to N2 X0 males where RAD-51 foci were shifted to later meiotic prophase substages and overall levels were higher. | We observed HIM-3 on the single X chromosome in pachytene nuclei in the male germ line as well as in fem-3(lf) germ lines. Furthermore, in the fem-3(lf) X0 mutant HIM-3 was maintained on the single X in diakinesis as in N2 XX hermaphrodites. | HTP-1, HTP-2, and HTP-3 were loaded onto both the paired Xs and the single X.| SYP-1 was not loaded on the single X of N2 males; however, 30% of fem-3(lf) X chromosomes had SYP-1 staining.Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
WBPhenotype:0000687 (11)
WBPhenotype:0000730Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
RemarkX0 germ lines are competent for physiological apoptosis as shown by the low levels of apoptotic bodies seen in control worms. | Analysis of apoptosis in X0 germ lines revealed low levels of basal apoptosis, even though they have anasynapsed X.Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
WBPhenotype:0000741Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
WBPhenotype:0001024Paper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
RemarkFew XO animals lacking only maternal fem-3 show vulval differentiation.Paper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
PenetranceLowPaper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
Range77Paper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
Maternal
WBPhenotype:0001348Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
RemarkIn fem-3(lf) X0 germ lines, the H3dimethylK9 foci remained intense until diakinesis, although there was some redistribution of the mark in diplotene. In N2 and him-8 hermaphrodites, this intense focus is redistributed throughout the genome in the transition from pachytene to diplotene; in N2 male germ lines, H3dimethylK9 persisted on the single X chromosome until the transition to spermatocytes.Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
WBPhenotype:0001357Paper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
RemarkXO animals lacking only maternal fem-3 have abnormal gonadsPaper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
PenetranceIncompletePaper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
Range3131Paper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00000922
Curator_confirmedWBPerson2021
Maternal
WBPhenotype:0001824Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
RemarkMeiotic prophase timing in these X0 mutants was slow (54-60 hr), similar to N2 XX hermaphrodites. Progression of labeled nuclei through each prophase substage similarly paralleled N2 XX hermaphrodites.Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000061Paper_evidenceWBPaper00001837
Curator_confirmedWBPerson712
RemarkLifespans of animals were normal.Paper_evidenceWBPaper00001837
Curator_confirmedWBPerson712
WBPhenotype:0000717Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
RemarkIn the germ lines of both N2 X0 males and fem-3(lf) X0 females transcription of two X-linked oocyte-enriched genes, which are activated in late pachytene in hermaphrodites, was not activated.Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
ReferenceWBPaper00035521
WBPaper00001837
WBPaper00022032
WBPaper00016316
WBPaper00000922
WBPaper00013845
WBPaper00012610
MethodAllele