WormBase Tree Display for Variation: WBVar00144284

WBVar00144284 Evidence: Paper_evidence: WBPaper00002473
  Name: Public_name: e1756
    Other_name: CE29089:p.Gln271Ter
      D2045.6.1:c.811C>T
    HGVSg: CHROMOSOME_III:g.10472102C>T
  Sequence_details: SMap: S_parent: Sequence: D2045
    Flanking_sequences: tacatgattaaagtggagacaagacttaat aagaggatgatcgctgtcaactctacctga
    Mapping_target: D2045
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00002473
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00028849
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00000836
    Transcript: D2045.6.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: D2045.6.1:c.811C>T
        HGVSp: CE29089:p.Gln271Ter
        cDNA_position: 812
        CDS_position: 811
        Protein_position: 271
        Exon_number: 3/8
        Codon_change: Caa/Taa
        Amino_acid_change: Q/*
  Genetics: Interpolated_map_position: III 2.51832
    Mapping_data: In_2_point: 671
      In_multi_point: 584
        585
        586
        1245
        2318
  Description: Phenotype: WBPhenotype:0000358 Paper_evidence: WBPaper00004382
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: cul-1(lf) allele shows a pronounced hyperproliferation of vulval cells Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
          Normal L1, extra cell divisions in most post-embryonic lineages (about 4-fold increase; extra cells smaller, but differentiate); sterile. Easy to score (ES3) in adult. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00004382
                Curator_confirmed: WBPerson2021
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
      WBPhenotype:0000695 Paper_evidence: WBPaper00004382
        Curator_confirmed: WBPerson2021
        Remark: The morphology of vulval cell nuclei in cul-1 mutants appeared somewhat indistinct relative to wild-type animals. Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00004382
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000699 Paper_evidence: WBPaper00004382
        Curator_confirmed: WBPerson2021
        Remark: Vulval cells in cul-1 mutants do not initiate ingression until after the third cycle, whereas wild-type vulval cells begin to invaginate following the second division cycle Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00004382
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000746 Paper_evidence: WBPaper00004382
        Curator_confirmed: WBPerson2021
        Remark: Vulval cell divisions in cul-1 mutants occur in a somewhat less synchronous manner than those generally observed in wild type Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00004382
                Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000318 Paper_evidence: WBPaper00004382
        Curator_confirmed: WBPerson2021
        Remark: Vulval cell-cycle lengths are similar to that of wildtype animals (1.75-2.5 hours) Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00004382
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000354 Paper_evidence: WBPaper00004382
        Curator_confirmed: WBPerson2021
        Remark: Despite extra division cycles, vulval cells in cul-1 mutants can execute differentiation programs and acquire their correct terminal fates Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004382
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00004382
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: mgIs21 [lin-11::GFP], ayIs4 [egl-17::GFP] Paper_evidence: WBPaper00004382
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001219 Paper_evidence: WBPaper00032114
        Curator_confirmed: WBPerson2021
        Remark: Hermaphrodites do not exhibit any defects in sex-specific CEM apoptosis Paper_evidence: WBPaper00032114
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: smIs26 [pkd-2p::gfp] Paper_evidence: WBPaper00032114
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00004382
    WBPaper00032114
  Method: Substitution_allele