WormBase Tree Display for Variation: WBVar00144280
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| WBVar00144280 | Name | Public_name | e1751 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sequence_details | SeqStatus | Pending_curation | |||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain | WBStrain00004458 | ||||||||
| Laboratory | CB | ||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00003102 | |||||||
| Interactor | WBInteraction000052189 | ||||||||
| WBInteraction000052215 | |||||||||
| WBInteraction000500065 | |||||||||
| WBInteraction000500066 | |||||||||
| WBInteraction000519196 | |||||||||
| WBInteraction000524338 | |||||||||
| Genetics | Mapping_data | In_2_point | 673 | ||||||
| In_multi_point | 588 | ||||||||
| 589 | |||||||||
| 590 | |||||||||
| Description | Phenotype | WBPhenotype:0000469 | Paper_evidence | WBPaper00002582 | |||||
| WBPaper00001492 | |||||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPerson2987 | |||||||||
| Remark | QL initially migrated posteriorly; however, her descendants migrated towards the anterior. The final position of QL.pa daughters were displaced anteriorly compared to controls. | Paper_evidence | WBPaper00002582 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| QR descendants aberrantly migrate to the posterior of the animal, similar to QL descendants (Figure 1); "As an independent confirmation that mab-5 expression is sufficient to make the QR descendants stay in the posterior, we examined animals carrying a putative mab-5 gain-of-function allele, e1751 (ref. 12). The effects of e1751 are similar to those seen with the heat-shock construct (Fig. 1e)." | Paper_evidence | WBPaper00001492 | |||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Variation_effect | Gain_of_function_undetermined_type | Paper_evidence | WBPaper00001492 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Hypermorph_gain_of_function | Paper_evidence | WBPaper00002582 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0007279 | PATO:0000460 | Paper_evidence | WBPaper00001492 | ||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBbt:0003927 | PATO:0000460 | Paper_evidence | WBPaper00001492 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBbt:0007281 | PATO:0000460 | Paper_evidence | WBPaper00001492 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBbt:0007282 | PATO:0000460 | Paper_evidence | WBPaper00001492 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBbt:0004991 | PATO:0000460 | Paper_evidence | WBPaper00001492 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| WBbt:0003832 | PATO:0000460 | Paper_evidence | WBPaper00001492 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| GO_term | GO:0016477 | PATO:0000460 | Paper_evidence | WBPaper00001492 | |||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Phenotype_assay | Temperature | 20 | Paper_evidence | WBPaper00002582 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| Genotype | him-5(e1490) | Paper_evidence | WBPaper00001492 | ||||||
| Curator_confirmed | WBPerson2987 | ||||||||
| Phenotype_not_observed | WBPhenotype:0000239 | Paper_evidence | WBPaper00004710 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | mab-5(e1751) hermaphrodites still exhibit a wild-type Pn.p cell fusion pattern because MAB-5 is inactive in wildtype hermaphrodites. | Paper_evidence | WBPaper00004710 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Variation_effect | Hypermorph_gain_of_function | Paper_evidence | WBPaper00004710 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000469 | Paper_evidence | WBPaper00031356 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Variation_effect | Hypermorph_gain_of_function | Paper_evidence | WBPaper00031356 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Anatomy_term | WBbt:0004056 | PATO:0000460 | Paper_evidence | WBPaper00031356 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBbt:0004054 | PATO:0000460 | Paper_evidence | WBPaper00031356 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Life_stage | WBls:0000024 | PATO:0000460 | Paper_evidence | WBPaper00031356 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Treatment | Q descendants were scored, by Nomarski, in newly hatched L1s and l1s 10-12 hrs after hatching. QL migration was scored as defective when PVM and SDQL were positioned anterior to the V4.p cell, indicating an anterior (wrong) direction of migration for the cell. QR migration was scored as defective when AVM and SDQR were positioned posterior to V2.p. indicating under-migration. | Paper_evidence | WBPaper00031356 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001660 | Paper_evidence | WBPaper00006052 | |||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Remark | No disruption of ASE asymmetry (as seen with lim-6 reporters) | Paper_evidence | WBPaper00006052 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Variation_effect | Hypermorph_gain_of_function | Paper_evidence | WBPaper00006052 | ||||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Phenotype_assay | Genotype | otIs114, otIs6 | Paper_evidence | WBPaper00006052 | |||||
| Curator_confirmed | WBPerson2021 | ||||||||
| Reference (18) | |||||||||
| Method | Allele |
