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WormBase Tree Display for Variation: WBVar00144275

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Name Class

WBVar00144275EvidencePaper_evidenceWBPaper00003082
NamePublic_namee1745
Other_namee1745ts
CE51835:p.Trp1094Ter
CE32051:p.Trp1072Ter
F56D1.4d.1:c.3210G>A
F56D1.4e.1:c.3282G>A
F56D1.4a.1:c.3216G>A
F56D1.4b.1:c.3321G>A
CE32052:p.Trp1107Ter
CE26369:p.Trp1070Ter
HGVSgCHROMOSOME_II:g.5472274G>A
Sequence_detailsSMapS_parentSequenceF56D1
Flanking_sequencestgtgttcatctacaaagcacttgcggaatgcacatgtatggtgatactgatgaagatgtt
Mapping_targetF56D1
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00003082
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (24)
LaboratoryCB
StatusLive
AffectsGeneWBGene00000548
TranscriptF56D1.4a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF56D1.4a.1:c.3216G>A
HGVSpCE32051:p.Trp1072Ter
cDNA_position3331
CDS_position3216
Protein_position1072
Exon_number17/20
Codon_changetgG/tgA
Amino_acid_changeW/*
F56D1.4e.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF56D1.4e.1:c.3282G>A
HGVSpCE51835:p.Trp1094Ter
cDNA_position3282
CDS_position3282
Protein_position1094
Exon_number17/20
Codon_changetgG/tgA
Amino_acid_changeW/*
F56D1.4b.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF56D1.4b.1:c.3321G>A
HGVSpCE32052:p.Trp1107Ter
cDNA_position3417
CDS_position3321
Protein_position1107
Exon_number18/21
Codon_changetgG/tgA
Amino_acid_changeW/*
F56D1.4d.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF56D1.4d.1:c.3210G>A
HGVSpCE26369:p.Trp1070Ter
cDNA_position3326
CDS_position3210
Protein_position1070
Exon_number17/20
Codon_changetgG/tgA
Amino_acid_changeW/*
Interactor (35)
GeneticsInterpolated_map_positionII-1.29801
Mapping_dataIn_2_point4225
In_multi_point850
851
852
853
881
882
1384
1789
2326
3137
In_pos_neg_data3803
7105
7111
7118
7120
7129
7133
DescriptionPhenotypeWBPhenotype:0000062Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkInviable at 25C. Easy to score (ES3) at 25C, difficult to score (ES2) at 20C.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000195Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Remark"At 18C, clr-1(e1745) animals are phenotypically wild-type for fluid accumulation and exhibit normal patterns of DTC migration (Fig. 4B). However, in double mutants with an unc-5 hypomorph or null allele, a significant increase in the frequency of anterior and/or posterior DTC migration defects was observed (Fig. 4C)."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006865PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Phenotype_assayTemperature18Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Genotypeunc-5(e152)Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
unc-5(e53)Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
unc-5(ev585)Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
WBPhenotype:0000426Paper_evidenceWBPaper00006119
Curator_confirmedWBPerson1754
RemarkInduces an increase in di-phosphorylation of MPK-1 at restrictive temperaturePaper_evidenceWBPaper00006119
Curator_confirmedWBPerson1754
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00006119
Curator_confirmedWBPerson1754
WBPhenotype:0000691Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Remark"The severe phenotype of clr-1(e1745) when shifted to the restrictive temperature of 25C, including gonadal rupture, precludes examination of the effects of a strong reduction of function of clr-1 (Fig. 4A)."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
WBPhenotype:0000882Person_evidenceWBPerson33324
Curator_confirmedWBPerson33324
RemarkPVD branching defect and ectopic branches increase when shifting to the restrictive temperaturePerson_evidenceWBPerson33324
Curator_confirmedWBPerson33324
WBPhenotype:0001010Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkstarved translucent appearance at 20C, facilitating Nomarski visualization of neuron processes; phenocopied by growth on 1mM orthovanadate. Inviable at 25C. Suppresses egl-15(n1477ts), and SM Mig defect of egl-17(1313)ES3 (25C) ES2 (20C)Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001645Paper_evidenceWBPaper00006119
Curator_confirmedWBPerson1754
RemarkInduces muscle protein degradation at restrictive temperaturePaper_evidenceWBPaper00006119
Curator_confirmedWBPerson1754
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00006119
Curator_confirmedWBPerson1754
Phenotype_not_observedWBPhenotype:0000195Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Remark"At 18C, clr-1(e1745) animals are phenotypically wild-type for fluid accumulation and exhibit normal patterns of DTC migration (Fig. 4B)."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006865PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Phenotype_assayTemperature18Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
WBPhenotype:0001984Paper_evidenceWBPaper00038105
Curator_confirmedWBPerson712
RemarkAnimals do not exhibit any short- or long-range axon migration defects.Paper_evidenceWBPaper00038105
Curator_confirmedWBPerson712
WBPhenotype:0001985Paper_evidenceWBPaper00038105
Curator_confirmedWBPerson712
RemarkAnimals do not exhibit any short- or long-range axon migration defects.Paper_evidenceWBPaper00038105
Curator_confirmedWBPerson712
WBPhenotype:0002469Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
RemarkThe probability and size of response to plate taps decreased with continued taps applied with a 10s interval, similar to the response of N2 animals.Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
WBPhenotype:0004027Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
RemarkAnimals exhibit an escape response (reversal) similar to N2 animals upon an initial plate tap.Paper_evidenceWBPaper00038487
Curator_confirmedWBPerson712
Reference (20)
MethodSubstitution_allele