WormBase Tree Display for Variation: WBVar00144072

WBVar00144072 Evidence: Paper_evidence: WBPaper00002018
  Name: Public_name: e1522
    Other_name: ZK154.3.1:c.949T>A
      CE15257:p.Phe317Ile
    HGVSg: CHROMOSOME_X:g.7775395A>T
  Sequence_details: SMap: S_parent: Sequence: ZK154
    Flanking_sequences: caacctccttcatgctcattcttcctcgga aatggcagcagcggtgagataacgtccatg
    Mapping_target: ZK154
    Type_of_mutation: Substitution: a t Curator_confirmed: WBPerson4055
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00003171
    Transcript: ZK154.3.1 (11)
  Genetics: Interpolated_map_position: X -1.27626
  Description: Phenotype: WBPhenotype:0000315 Paper_evidence: WBPaper00000550
        Curator_confirmed: WBPerson95
        Remark: Mutants heterozygous (but not homozygous) for mec-7 alleles e1505, e1343, e1522, and e1527 have a temperature-sensitive Mec phenotype, i.e., they are temperature sensitive dominants. Temperature-shift experiments with e1343/+ and e1522/+ heterozygotes suggest that mec-7 is needed throughout larval development for adult touch sensitivity. Paper_evidence: WBPaper00000550
            Curator_confirmed: WBPerson95
        Dominant: Paper_evidence: WBPaper00000550
          Curator_confirmed: WBPerson95
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00000550
              Curator_confirmed: WBPerson95
        Phenotype_assay: Genotype: e1522/+ Paper_evidence: WBPaper00000550
              Curator_confirmed: WBPerson95
      WBPhenotype:0000456 Paper_evidence: WBPaper00000502
        Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00000502
          Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20C Paper_evidence: WBPaper00000502
              Curator_confirmed: WBPerson712
      WBPhenotype:0000905 Paper_evidence: WBPaper00000502
        Curator_confirmed: WBPerson712
        Remark: Touch cells lack large specialized microtubules. Paper_evidence: WBPaper00000502
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00000502
          Curator_confirmed: WBPerson712
        Phenotype_assay: Temperature: 20C Paper_evidence: WBPaper00000502
              Curator_confirmed: WBPerson712
  Reference: WBPaper00000502
    WBPaper00002018
    WBPaper00000550
  Remark: Variation flanks and nucleotide change automatically updated to be on the positive strand to fix mapping and gff dumping issues.
    [200224 mh6] reverse complemented/swapped the change and flanks to move the variation onto the plus strand Curator_confirmed: WBPerson4055
  Method: Substitution_allele