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WormBase Tree Display for Variation: WBVar00144066

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Name Class

WBVar00144066EvidencePaper_evidenceWBPaper00002482
NamePublic_namee1515
Other_nameF16F9.5.1:c.314C>T
CE09444:p.Ser105Phe
HGVSgCHROMOSOME_X:g.8469880G>A
Sequence_detailsSMapS_parentSequenceT01B10
Flanking_sequencesggcatttacaacagttttgctataaaacattagtcatggtattccaatgcttgggcaagc
Mapping_targetT01B10
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00002482
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004352
WBStrain00004462
LaboratoryCB
StatusLive
AffectsGeneWBGene00003174
TranscriptF16F9.5.1VEP_consequencemissense_variant
VEP_impactMODERATE
HGVScF16F9.5.1:c.314C>T
HGVSpCE09444:p.Ser105Phe
cDNA_position388
CDS_position314
Protein_position105
Exon_number3/19
Codon_changetCt/tTt
Amino_acid_changeS/F
GeneticsInterpolated_map_positionX0.0292771
Mapping_dataIn_multi_point423
424
In_pos_neg_data2232
DescriptionPhenotypeWBPhenotype:0000324Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000353Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000398Paper_evidenceWBPaper00031965
WBPaper00061677
Curator_confirmedWBPerson712
RemarkAnimals fail to respond to light touch applied manually with an eyelash.Paper_evidenceWBPaper00031965
Curator_confirmedWBPerson712
mec-10 has a roughly 70% reduction in gentle touch responsePaper_evidenceWBPaper00061677
Curator_confirmedWBPerson712
WBPhenotype:0000456Paper_evidenceWBPaper00000502
WBPaper00040149
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkOn average, mec-10 mutant animals respond only to 1-4 touches of 10, whereas wild-type animals respond to 9 touches of 10.Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
touch insensitivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000502
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
Ease_of_scoringES2_Difficult_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000542Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000646Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarklethargicPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000679Paper_evidenceWBPaper00030928
Curator_confirmedWBPerson48778
RemarkDAF-16::GFP nuclear accumulation does not occur as a result of 100G gravitational force as in control worms (Figure 7a)Paper_evidenceWBPaper00030928
Curator_confirmedWBPerson48778
WBPhenotype:0001506Paper_evidenceWBPaper00049074
Curator_confirmedWBPerson6118
Remarkenhanced reversing rate off food and reduced reversing rate on food compared to N2Paper_evidenceWBPaper00049074
Curator_confirmedWBPerson6118
Phenotype_assayControl_strainWBStrain00000001Paper_evidenceWBPaper00049074
Curator_confirmedWBPerson6118
WBPhenotype:0001639Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001773Paper_evidenceWBPaper00031965
Curator_confirmedWBPerson712
RemarkAnimals do not show an increased speed when placed in liquid-filled, microfluidic chambers containing a square array of posts. Animals moved much more slowly compared to wild type in these chambers and failed to sustain the enhanced swimming pattern exhibited by wild-type animals.Paper_evidenceWBPaper00031965
Curator_confirmedWBPerson712
WBPhenotype:0002028Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
RemarkMutants have MRCs with a dramatic reduction in peak MRC size compared to wild-type. Touch receptor neuron respond to applied pressure stimulus. Latency for MRC off response are extended compared to wild type. Mutations in MEC-10 shifted the reversal potential for MRCs by -40 mV or more.Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005490PATO:0000460Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
WBPhenotype:0002284Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002288Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002291Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002295Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002299Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002301Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002310Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002312Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002324Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002336Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002347Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002592Paper_evidenceWBPaper00030928
Curator_confirmedWBPerson48778
RemarkDAF-16::GFP nuclear accumulation does not occur as a result of 100G gravitational force as in control worms (Figure 7a)Paper_evidenceWBPaper00030928
Curator_confirmedWBPerson48778
WBPhenotype:0004022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004023Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000397Paper_evidenceWBPaper00061677
Curator_confirmedWBPerson712
Remarkmec-10 has a normal response to harsh touchPaper_evidenceWBPaper00061677
Curator_confirmedWBPerson712
WBPhenotype:0000412Paper_evidenceWBPaper00003408
Curator_confirmedWBPerson557
WBPhenotype:0000436Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
RemarkThe distribution of the mechanoreceptor channels along the process of PLM touch receptor neurons is essentially unchanged in mec-10 mutants as assayed by the localization pattern of MEC-4::YFP and anti-MEC-2 antibody staining.Paper_evidenceWBPaper00040149
Curator_confirmedWBPerson712
WBPhenotype:0000643Paper_evidenceWBPaper00031965
Curator_confirmedWBPerson712
RemarkAnimals showed no differences in movement on agar compared to wild-type animals.Paper_evidenceWBPaper00031965
Curator_confirmedWBPerson712
WBPhenotype:0000663Paper_evidenceWBPaper00003408
Curator_confirmedWBPerson557
WBPhenotype:0000738Paper_evidenceWBPaper00061677
Curator_confirmedWBPerson712
RemarkOf these mutants, only mec-3 showed a significantly lower precipice response frequency than N2 (Figure 1B,C).Paper_evidenceWBPaper00061677
Curator_confirmedWBPerson712
WBPhenotype:0001221Paper_evidenceWBPaper00003408
Curator_confirmedWBPerson557
WBPhenotype:0001700Paper_evidenceWBPaper00031965
Curator_confirmedWBPerson712
RemarkAnimals showed no differences in movement in bulk fluids compared to wild-type animals.Paper_evidenceWBPaper00031965
Curator_confirmedWBPerson712
ReferenceWBPaper00040149
WBPaper00043908
WBPaper00000502
WBPaper00031965
WBPaper00049074
WBPaper00003408
WBPaper00030928
WBPaper00061677
WBPaper00065340
MethodSubstitution_allele