WormBase Tree Display for Variation: WBVar00144038
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| WBVar00144038 | Evidence | Paper_evidence | WBPaper00026986 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Public_name | e1489 | |||||||
| Other_name | T07G12.12a.1:c.775G>A | ||||||||
| CE36715:p.Gly259Arg | |||||||||
| HGVSg | CHROMOSOME_IV:g.10563247G>A | ||||||||
| Sequence_details | SMap | S_parent | Sequence | T07G12 | |||||
| Flanking_sequences | aatcgagcaattgcgtggaagaggaaatat | gaaaacttcgtcttatcgatcacgcattgg | |||||||
| Mapping_target | T07G12 | ||||||||
| Type_of_mutation | Substitution | g | a | Paper_evidence | WBPaper00026986 | ||||
| SeqStatus | Sequenced | ||||||||
| Variation_type | Allele | ||||||||
| Origin | Species | Caenorhabditis elegans | |||||||
| Strain | WBStrain00000074 | ||||||||
| WBStrain00000092 | |||||||||
| WBStrain00003829 | |||||||||
| WBStrain00003984 | |||||||||
| WBStrain00003987 | |||||||||
| WBStrain00004346 | |||||||||
| WBStrain00004528 | |||||||||
| WBStrain00004551 | |||||||||
| WBStrain00004578 | |||||||||
| WBStrain00004615 | |||||||||
| WBStrain00004633 | |||||||||
| WBStrain00004636 | |||||||||
| WBStrain00004637 | |||||||||
| WBStrain00004653 | |||||||||
| WBStrain00004654 | |||||||||
| WBStrain00004698 | |||||||||
| WBStrain00004738 | |||||||||
| WBStrain00004765 | |||||||||
| WBStrain00005481 | |||||||||
| WBStrain00005496 | |||||||||
| WBStrain00006240 | |||||||||
| WBStrain00006241 | |||||||||
| WBStrain00006242 | |||||||||
| WBStrain00006243 | |||||||||
| WBStrain00006244 | |||||||||
| WBStrain00006246 | |||||||||
| WBStrain00006406 | |||||||||
| WBStrain00006407 | |||||||||
| WBStrain00006408 | |||||||||
| WBStrain00006409 | |||||||||
| WBStrain00006413 | |||||||||
| WBStrain00006442 | |||||||||
| WBStrain00006443 | |||||||||
| WBStrain00006444 | |||||||||
| WBStrain00006445 | |||||||||
| WBStrain00006446 | |||||||||
| WBStrain00006447 | |||||||||
| WBStrain00006448 | |||||||||
| WBStrain00006652 | |||||||||
| WBStrain00006957 | |||||||||
| WBStrain00007127 | |||||||||
| WBStrain00007273 | |||||||||
| WBStrain00007275 | |||||||||
| WBStrain00007280 | |||||||||
| WBStrain00007284 | |||||||||
| WBStrain00007289 | |||||||||
| WBStrain00007293 | |||||||||
| WBStrain00007298 | |||||||||
| WBStrain00007306 | |||||||||
| WBStrain00007314 | |||||||||
| WBStrain00007317 | |||||||||
| WBStrain00007318 | |||||||||
| WBStrain00007319 | |||||||||
| WBStrain00007321 | |||||||||
| WBStrain00007322 | |||||||||
| WBStrain00007324 | |||||||||
| WBStrain00007325 | |||||||||
| WBStrain00007328 | |||||||||
| WBStrain00007342 | |||||||||
| WBStrain00007344 | |||||||||
| WBStrain00007351 | |||||||||
| WBStrain00007353 | |||||||||
| WBStrain00022497 | |||||||||
| WBStrain00022498 | |||||||||
| WBStrain00022554 | |||||||||
| WBStrain00022735 | |||||||||
| WBStrain00023443 | |||||||||
| WBStrain00024103 | |||||||||
| WBStrain00024106 | |||||||||
| WBStrain00024121 | |||||||||
| WBStrain00028625 | |||||||||
| WBStrain00028626 | |||||||||
| WBStrain00029247 | |||||||||
| WBStrain00029248 | |||||||||
| WBStrain00029468 | |||||||||
| WBStrain00029511 | |||||||||
| WBStrain00029553 | |||||||||
| WBStrain00029591 | |||||||||
| WBStrain00029592 | |||||||||
| WBStrain00029647 | |||||||||
| WBStrain00029935 | |||||||||
| WBStrain00030567 | |||||||||
| WBStrain00030689 | |||||||||
| WBStrain00030692 | |||||||||
| WBStrain00034112 | |||||||||
| WBStrain00034391 | |||||||||
| WBStrain00034470 | |||||||||
| WBStrain00034922 | |||||||||
| WBStrain00035093 | |||||||||
| WBStrain00035115 | |||||||||
| WBStrain00035128 | |||||||||
| WBStrain00035131 | |||||||||
| WBStrain00035132 | |||||||||
| WBStrain00035133 | |||||||||
| WBStrain00035134 | |||||||||
| WBStrain00035137 | |||||||||
| WBStrain00035139 | |||||||||
| WBStrain00035154 | |||||||||
| WBStrain00040442 | |||||||||
| WBStrain00040595 | |||||||||
| WBStrain00047418 | |||||||||
| WBStrain00048856 | |||||||||
| WBStrain00048857 | |||||||||
| WBStrain00049518 | |||||||||
| WBStrain00049519 | |||||||||
| WBStrain00051814 | |||||||||
| WBStrain00051829 | |||||||||
| WBStrain00051835 | |||||||||
| WBStrain00051837 | |||||||||
| WBStrain00053676 | |||||||||
| WBStrain00054543 | |||||||||
| WBStrain00054952 | |||||||||
| WBStrain00054953 | |||||||||
| WBStrain00054958 | |||||||||
| WBStrain00055047 | |||||||||
| WBStrain00056051 | |||||||||
| WBStrain00056052 | |||||||||
| WBStrain00056430 | |||||||||
| WBStrain00056432 | |||||||||
| WBStrain00056435 | |||||||||
| WBStrain00056440 | |||||||||
| WBStrain00056441 | |||||||||
| WBStrain00056471 | |||||||||
| WBStrain00056472 | |||||||||
| WBStrain00056473 | |||||||||
| WBStrain00056484 | |||||||||
| WBStrain00056485 | |||||||||
| Laboratory | CB | ||||||||
| NFB | |||||||||
| OH | |||||||||
| CHB | |||||||||
| Status | Live | ||||||||
| Affects | Gene | WBGene00001867 | |||||||
| Transcript | T07G12.12a.1 (12) | ||||||||
| Genetics | Interpolated_map_position | IV | 4.63927 | ||||||
| Mapping_data | In_2_point | 317 | |||||||
| In_multi_point (12) | |||||||||
| In_pos_neg_data | 961 | ||||||||
| 968 | |||||||||
| 969 | |||||||||
| 4251 | |||||||||
| 4689 | |||||||||
| Description | Phenotype | WBPhenotype:0000583 | Paper_evidence | WBPaper00001077 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals segregate 5% XXX (Dumpy) progeny. | Paper_evidence | WBPaper00001077 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | Low | Paper_evidence | WBPaper00001077 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000742 | Paper_evidence | WBPaper00000179 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals exhibit reduced recombination (9%) compared to wild type. | Paper_evidence | WBPaper00000179 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00000179 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000863 | Paper_evidence | WBPaper00000179 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Males exhibit 8.8% wild type fertility. | Paper_evidence | WBPaper00000179 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00000179 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001175 | Paper_evidence | WBPaper00001077 | |||||||
| WBPaper00000565 | |||||||||
| WBPaper00000179 | |||||||||
| WBPaper00048917 | |||||||||
| Person_evidence | WBPerson136 | ||||||||
| WBPerson261 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson712 | |||||||||
| WBPerson721 | |||||||||
| Remark | Little or no autosomal missegregation. | Person_evidence | WBPerson136 | ||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Male self-progeny make up 30.3% population as measured from 8 broods, 895 total animals. | Paper_evidence | WBPaper00000565 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Animals segregate 36.7% males compared to 0.3% segregated by wild type animals. | Paper_evidence | WBPaper00000179 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Self-progeny 37% XO male, 6% 3X herm, 38% nullo-X ova as a result of reductional meiotic nondisjunction X chromosome recombination specifically reduced 90% except at left end (increased). Easy to score (ES3) as progeny. | Person_evidence | WBPerson261 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Penetrance | Incomplete | Person_evidence | WBPerson136 | ||||||
| Curator_confirmed | WBPerson48 | ||||||||
| 31% | Paper_evidence | WBPaper00001077 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Range | 39 | 39 | Person_evidence | WBPerson136 | |||||
| Curator_confirmed | WBPerson48 | ||||||||
| Recessive | Person_evidence | WBPerson136 | |||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Ease_of_scoring | ES3_Easy_to_score | Person_evidence | WBPerson261 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001583 | Paper_evidence | WBPaper00000179 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals segregate a small percentage (6.4%) of short animals shown to be 3X hermaphrodites (wild type segregates 0.04% 3X herm.). | Paper_evidence | WBPaper00000179 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00000179 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_not_observed | WBPhenotype:0000050 | Paper_evidence | WBPaper00000179 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | 0.8% eggs never hatch, yet are refractile, similar in percent to those from wild type animals. | Paper_evidence | WBPaper00000179 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000062 | Paper_evidence | WBPaper00001077 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals produce 4% dead embryos and L1 (n=1597), not unlike wild type, which produce 2% dead L1 (n=1755). | Paper_evidence | WBPaper00001077 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000143 | Paper_evidence | WBPaper00000565 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Treatment | UV sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 1Jm 10X-2/sec. Irradiated animals were protected from light. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls. | Paper_evidence | WBPaper00000565 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000154 | Paper_evidence | WBPaper00000179 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals have an average brood size of 30237 s.d. (6 broods counted), wild type has average brood size 33034 s.d. (8 broods counted). | Paper_evidence | WBPaper00000179 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000057 | PATO:0000460 | Paper_evidence | WBPaper00000179 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000276 | Paper_evidence | WBPaper00000565 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Phenotype_assay | Treatment | X-ray sensitivities were measured as % survival based on radiation dose. Alkaline bleach isolated eggs ranging in age from 30-180 minutes were aliquoted to plates to give between 25-300 survivors/plate. The plated eggs were irradiated at different doses at a rate of 470 r/min. Survival was scored as the % animals reaching adulthood 4-6 days after irradiation relative to un-irradiated controls. | Paper_evidence | WBPaper00000565 | |||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000517 | Paper_evidence | WBPaper00000179 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Animals are indistinguishable from wild type in terms of behavior. | Paper_evidence | WBPaper00000179 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000520 | Paper_evidence | WBPaper00000179 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Both hermaphrodites and males are indistinguishable from wild type in terms of superficial anatomy. | Paper_evidence | WBPaper00000179 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0000673 | Paper_evidence | WBPaper00001077 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Average brood size 254 38 (n=1597) | Paper_evidence | WBPaper00001077 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0001631 | Paper_evidence | WBPaper00000179 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | The sex ratio of cross progeny sired by him males does not significantly differ from 1:1. | Paper_evidence | WBPaper00000179 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| EQ_annotations | Life_stage | WBls:0000056 | PATO:0000460 | Paper_evidence | WBPaper00000179 | ||||
| Curator_confirmed | WBPerson712 | ||||||||
| WBPhenotype:0002140 | Paper_evidence | WBPaper00032050 | |||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Remark | Males responded to ascr#3, an ascaroside, in male attraction assays. | Paper_evidence | WBPaper00032050 | ||||||
| Curator_confirmed | WBPerson712 | ||||||||
| Reference (29) | |||||||||
| Remark | Allele incorrectly cited as e1389 | Paper_evidence | WBPaper00003393 | ||||||
| Allele incorrectly cited as e2489 | Paper_evidence | WBPaper00003294 | |||||||
| Variation stub/paper connection generated from the May 2021 NN VFP dataset. | |||||||||
| Created by WBPerson51134 from the NN_VFP_triage_pipeline | |||||||||
| Method | Substitution_allele |
