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WormBase Tree Display for Variation: WBVar00143995

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Name Class

WBVar00143995EvidencePerson_evidenceWBPerson201
NamePublic_namee1421
Other_name (13)
HGVSgCHROMOSOME_II:g.14658033C>T
Sequence_detailsSMapS_parentSequenceZC101
Flanking_sequencescgctgctccaccacaagtcgaagctcgttatttttgcattgaacatttctatccttaagt
Mapping_targetZC101
Type_of_mutationSubstitutiongaPerson_evidenceWBPerson201
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004332
LaboratoryCB
StatusLive
AffectsGeneWBGene00006787
Transcript (13)
Interactor (14)
GeneticsInterpolated_map_positionII23.3128
DescriptionPhenotypeWBPhenotype:0000006Person_evidenceWBPerson201
Curator_confirmedWBPerson48
RemarkAdults are partially egg-laying defective.Person_evidenceWBPerson201
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson201
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson201
Curator_confirmedWBPerson48
Variation_effectHypomorph_reduction_of_functionPerson_evidenceWBPerson201
Curator_confirmedWBPerson48
EQ_annotationsLife_stageWBls:0000057PATO:0000460Person_evidenceWBPerson201
Curator_confirmedWBPerson48
WBPhenotype:0000164Person_evidenceWBPerson201
Curator_confirmedWBPerson48
RemarkAdults are thin.Person_evidenceWBPerson201
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson201
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson201
Curator_confirmedWBPerson48
Variation_effectHypomorph_reduction_of_functionPerson_evidenceWBPerson201
Curator_confirmedWBPerson48
EQ_annotationsLife_stageWBls:0000041PATO:0000460Person_evidenceWBPerson201
Curator_confirmedWBPerson48
WBPhenotype:0000181Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
RemarkMutants exhibit initiation and termination problems in the dorsal and sub-ventral processes of the NSM, which often caused thickened endingsPaper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0003666PATO:0000460Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
Phenotype_assayGenotypezdIs13 [ tph-1p::GFP]Paper_evidenceWBPaper00031671
Curator_confirmedWBPerson2021
WBPhenotype:0000195Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Remark"Several previously described class I unc-52 alleles also showed significant increases in the frequency of DTC migration defects of weak unc-5 alleles. These include unc-52(e669), unc-52(e998), and unc-52(e1421) (Table 1)."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
"An increase in the frequency of DTC migration defects was also observed in double mutants of unc-52(e1421) and the hypomorphic unc-5(ev644) allele (P < 0.001), indicating that the enhancement of unc-5(e152) was not allele-specific. unc-5(ev644) caused defects in 1% of anterior and 16% (n = 145) of posterior DTCs. The double mutant unc-5(ev644); unc-52(1421) [sic] exhibited defects in 10% of anterior and 27% of posterior DTCs (n = 165)."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
"The low penetrance DTC defects of unc-5(ev585), unc-5(ev585)/+ (Table 1)... were also significantly enhanced by unc-52 class I mutants (Table 1)."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
"All class I unc-52 alleles (except e444) strongly enhanced the penetrance of DTC migration defects of a null allele of unc-5 (Table 1)."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
"To determine whether class I unc-52 mutations disrupted UNC-5 function, they were passed into a strain containing evIs99, an integrated emb-9::unc-5 transgenic array. In contrast to an unc-6 mutation (Su et al., 2000), unc-52(e1421) did not completely block precocious ventral-to-dorsal migrations (Fig. 3C). In evIs99 alone, precocious ventral-to-dorsal migrations occurred in 21% of anterior and 39% of posterior DTCs (n = 206). In the evls99; unc-52(e1421) background, these precocious migrations occurred in 11% (19/166; P < 0.005) of anterior and 38% (50/166; P > 0.4) of posterior DTCs. The frequency of these precocious migrations was significantly reduced relative to evIs99 alone only for the anterior DTCs."Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
PenetranceIncompletePaper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006865PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
Phenotype_assayGenotypeunc-5(e152)Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
unc-5(ev644)Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
unc-5(ev585)Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
unc-5(e53)Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
evIs99 [emb-9::unc-5]Paper_evidenceWBPaper00005809
Curator_confirmedWBPerson2987
WBPhenotype:0000349Person_evidenceWBPerson201
Curator_confirmedWBPerson48
RemarkAdults are limp.Person_evidenceWBPerson201
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson201
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson201
Curator_confirmedWBPerson48
Variation_effectHypomorph_reduction_of_functionPerson_evidenceWBPerson201
Curator_confirmedWBPerson48
EQ_annotationsLife_stageWBls:0000041PATO:0000460Person_evidenceWBPerson201
Curator_confirmedWBPerson48
WBPhenotype:0000553Paper_evidenceWBPaper00002086
Curator_confirmedWBPerson528
WBPhenotype:0000818Paper_evidenceWBPaper00002086
Curator_confirmedWBPerson528
WBPhenotype:0000868Person_evidenceWBPerson201
Curator_confirmedWBPerson48
RemarkAdults are paralysed (except for head region).Person_evidenceWBPerson201
Curator_confirmedWBPerson48
PenetranceCompletePerson_evidenceWBPerson201
Curator_confirmedWBPerson48
RecessivePerson_evidenceWBPerson201
Curator_confirmedWBPerson48
Variation_effectHypomorph_reduction_of_functionPerson_evidenceWBPerson201
Curator_confirmedWBPerson48
EQ_annotationsLife_stageWBls:0000041PATO:0000460Person_evidenceWBPerson201
Curator_confirmedWBPerson48
WBPhenotype:0000882Paper_evidenceWBPaper00046827
Curator_confirmedWBPerson23340
Remarkreduced and disorganized PVD 4th dendrites (Figure 2)Paper_evidenceWBPaper00046827
Curator_confirmedWBPerson23340
EQ_annotationsAnatomy_termWBbt:0006831PATO:0000460Paper_evidenceWBPaper00046827
Curator_confirmedWBPerson23340
GO_termGO:0016358PATO:0000460Paper_evidenceWBPaper00046827
Curator_confirmedWBPerson23340
GO:0030425PATO:0000937Paper_evidenceWBPaper00046827
Curator_confirmedWBPerson23340
PATO:0001997Paper_evidenceWBPaper00046827
Curator_confirmedWBPerson23340
Phenotype_not_observedWBPhenotype:0000060Paper_evidenceWBPaper00002086
Curator_confirmedWBPerson528
WBPhenotype:0000643Person_evidenceWBPerson201
Curator_confirmedWBPerson48
RemarkLarvae move well until early adulthood.Person_evidenceWBPerson201
Curator_confirmedWBPerson48
EQ_annotationsLife_stageWBls:0000023PATO:0000460Person_evidenceWBPerson201
Curator_confirmedWBPerson48
ReferenceWBPaper00031671
WBPaper00025979
WBPaper00005809
WBPaper00014555
WBPaper00002086
WBPaper00046827
MethodSubstitution_allele