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WormBase Tree Display for Variation: WBVar00143950

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Name Class

WBVar00143950EvidencePaper_evidenceWBPaper00031486
NamePublic_namee1371
Other_nameCE50158:p.Gly727Glu
Y55D5A.5e.1:c.2180G>A
Y55D5A.5d.1:c.2267G>A
CE46852:p.Gly803Glu
Y55D5A.5c.1:c.2408G>A
CE50312:p.Gly756Glu
Y55D5A.5a.1:c.2408G>A
CE50204:p.Gly803Glu
HGVSgCHROMOSOME_III:g.3010491C>T
Sequence_detailsSMapS_parentSequenceY55D5A
Flanking_sequencesttacgtgggaagcgccgctccaaccgaacgagacctcacgcattacacaattatgtggcg
Mapping_targetY55D5A
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00006380
LaboratoryCB
StatusLive
AffectsGeneWBGene00000898
TranscriptY55D5A.5e.1 (12)
Y55D5A.5a.1 (12)
Y55D5A.5c.1 (12)
Y55D5A.5d.1 (12)
GeneticsInterpolated_map_positionIII-8.07283
DescriptionPhenotypeWBPhenotype:0000061Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
RemarkThe mean lifespans at 20C +/- SE were: N2: 16.70.49; daf-2(e1371): 26.51.2.Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
WBPhenotype:0001184Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
RemarkWorms had mildly increased levels of fat storage (TAGs) compared to N2.Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
Phenotype_assayTreatmentSynchronized L1s were plated on mixed isotope feeding plates composed of 12C- and 13C-enriched E. coli cultures, and collected after 44-48 hr of feeding (worms were harvested as mid-L4 larvae). All experiments were carried out at 20 deg C.Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
Temperature20Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
WBPhenotype:0001742Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
RemarkWorms had mildly increased levels of synthesized fatty acids compared to N2.Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
Phenotype_assayTreatmentSynchronized L1s were plated on mixed isotope feeding plates composed of 12C- and 13C-enriched E. coli cultures, and collected after 44-48 hr of feeding (worms were harvested as mid-L4 larvae). All experiments were carried out at 20 deg C.Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
Temperature20Paper_evidenceWBPaper00032150
Curator_confirmedWBPerson712
WBPhenotype:0002267Paper_evidenceWBPaper00056618
Curator_confirmedWBPerson2977
Phenotype_not_observedWBPhenotype:0000681Paper_evidenceWBPaper00037649
Curator_confirmedWBPerson712
RemarkAnimals are as sensitive as WT.Paper_evidenceWBPaper00037649
Curator_confirmedWBPerson712
ReferenceWBPaper00037649
WBPaper00032150
WBPaper00056618
MethodSubstitution_allele