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WormBase Tree Display for Variation: WBVar00143933

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Name Class

WBVar00143933EvidencePaper_evidenceWBPaper00002018
NamePublic_namee1343
Other_nameCE15257:p.Pro171Leu
ZK154.3.1:c.512C>T
HGVSgCHROMOSOME_X:g.7775879G>A
Sequence_detailsSMapS_parentSequenceZK154
Flanking_sequencesaccggataatgaacaccttctcggtagttcaagtccaaaagtatccgacactgtagtcga
Mapping_targetZK154
Type_of_mutationSubstitutionct
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004341
WBStrain00004384
LaboratoryCB
StatusLive
AffectsGeneWBGene00003171
TranscriptZK154.3.1 (11)
GeneticsInterpolated_map_positionX-1.27579
Mapping_dataIn_2_point167
672
In_multi_point280
DescriptionPhenotypeWBPhenotype:0000315Paper_evidenceWBPaper00000550
Curator_confirmedWBPerson95
RemarkMutants heterozygous (but not homozygous) for mec-7 alleles e1505, e1343, e1522, and e1527 have a temperature-sensitive Mec phenotype, i.e., they are temperature sensitive dominants. Temperature-shift experiments with e1343/+ and e1522/+ heterozygotes suggest that mec-7 is needed throughout larval development for adult touch sensitivity.Paper_evidenceWBPaper00000550
Curator_confirmedWBPerson95
DominantPaper_evidenceWBPaper00000550
Curator_confirmedWBPerson95
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00000550
Curator_confirmedWBPerson95
Phenotype_assayGenotypee1343/+Paper_evidenceWBPaper00000550
Curator_confirmedWBPerson95
WBPhenotype:0000456Paper_evidenceWBPaper00000502
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkTouch insensitive, e1343/+ variably touch insensitive at 25C; wildtype at 15C.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Semi_dominantPaper_evidenceWBPaper00000502
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_assayTemperature20CPaper_evidenceWBPaper00000502
Curator_confirmedWBPerson712
Ease_of_scoringES2_Difficult_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000646Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarklethargic at 25CPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000905Paper_evidenceWBPaper00000502
Curator_confirmedWBPerson712
RemarkTouch cells lack large specialized microtubules.Paper_evidenceWBPaper00000502
Curator_confirmedWBPerson712
Semi_dominantPaper_evidenceWBPaper00000502
Curator_confirmedWBPerson712
Phenotype_assayTemperature20CPaper_evidenceWBPaper00000502
Curator_confirmedWBPerson712
WBPhenotype:0001588Paper_evidenceWBPaper00000550
Curator_confirmedWBPerson95
Remarkmec-7(e1343) mutants lack 15-protofilament microtubules in the touch receptor neurons (they have the 11-protofilament microtubules found in other cells.Paper_evidenceWBPaper00000550
Curator_confirmedWBPerson95
EQ_annotationsAnatomy_termWBbt:0005237PATO:0000460Paper_evidenceWBPaper00000550
Curator_confirmedWBPerson95
GO_termGO:0005874PATO:0000460Paper_evidenceWBPaper00000550
Curator_confirmedWBPerson95
WBPhenotype:0001676Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkmicrotubule cells lack 15-protofilament microtubulesPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
ReferenceWBPaper00000502
WBPaper00002018
WBPaper00015957
WBPaper00000550
MethodSubstitution_allele