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WormBase Tree Display for Variation: WBVar00143868

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Name Class

WBVar00143868EvidencePaper_evidenceWBPaper00004437
NamePublic_namee1259
Other_namee1259tsmat
F22B7.10.1:c.554G>A
CE26462:p.Gly185Asp
HGVSgCHROMOSOME_III:g.8662194C>T
Sequence_detailsSMapS_parentSequenceF22B7
Flanking_sequencesgaactgtagcttcatccattttttatttggtgttcttgttaggtgagcgacacaaaaatt
Mapping_targetF22B7
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (173)
LaboratoryCB
StatusLive
Linked_toWBVar02125049
AffectsGeneWBGene00001078
TranscriptF22B7.10.1 (12)
InteractorWBInteraction000052377
GeneticsInterpolated_map_positionIII-0.191392
Mapping_dataIn_2_point278
In_multi_point (56)
In_pos_neg_data802
810
812
1618
5742
Marked_rearrangementqC1[dpy-19(e1259) glp-1(q339) qIs26]
qC1[dpy-19(e1259) glp-1(q339)]
DescriptionPhenotypeWBPhenotype:0000469Paper_evidenceWBPaper00040419
WBPaper00004437
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPerson2987
RemarkAbnormal Q and Q daughter migrations. Weaker phenotype if mother dpy-19/+.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
The dpy-19(e1259) mutation results in a loss of QL.pax (QL.paa and QL.pap) neuroblast migration to the posterior of the animal (Figure S3).Paper_evidenceWBPaper00040419
Curator_confirmedWBPerson2987
"As predicted, we found that in unc-40 and dpy-19 mutants, the QL descendants sometimes migrated anteriorly and the QR descendants sometimes remained in the posterior (Fig. 7 and Hedgecock et al., 1990)."Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004086PATO:0000460Paper_evidenceWBPaper00040419
WBPaper00004437
Curator_confirmedWBPerson2987
WBbt:0004993PATO:0000460Paper_evidenceWBPaper00040419
WBPaper00004437
Curator_confirmedWBPerson2987
WBbt:0003832PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
WBbt:0004991PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00004437
Curator_confirmedWBPerson2987
Temperature_sensitiveHeat_sensitive20Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000583Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkDumpy (20C, 25C); WT (15C); easy to score (ES3) in adult at 25C. Weaker phenotype if mother dpy-19/+.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive20Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000648Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkMating not successful (ME0) at 25C; but mating successful (ME3) at 15C.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000505Paper_evidenceWBPaper00001328
Curator_confirmedWBPerson712
RemarkMales are not Ram.Paper_evidenceWBPaper00001328
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006941PATO:0000460Paper_evidenceWBPaper00001328
Curator_confirmedWBPerson712
Life_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00001328
Curator_confirmedWBPerson712
Phenotype_assayTemperature25CPaper_evidenceWBPaper00001328
Curator_confirmedWBPerson712
Genotypehim-5(e1490)Paper_evidenceWBPaper00001328
Curator_confirmedWBPerson712
ReferenceWBPaper00040419
WBPaper00029020
WBPaper00001328
WBPaper00013833
WBPaper00014840
WBPaper00004437
WBPaper00013682
WBPaper00065007
MethodSubstitution_allele