WormBase Tree Display for Variation: WBVar00143766

WBVar00143766 Evidence: Paper_evidence: WBPaper00042411
  Name: Public_name: e1128
    Other_name: CE51364:p.Ala150Val
      F26D11.10c.1:c.449C>T
      CE51518:p.Ala153Val
      CE51269:p.Ala150Val
      CE51310:p.Ala153Val
      F26D11.10b.1:c.458C>T
      F26D11.10a.1:c.458C>T
      F26D11.10d.1:c.449C>T
    HGVSg: CHROMOSOME_V:g.7964520G>A
  Sequence_details: SMap: S_parent: Sequence: F26D11
    Flanking_sequences: aatgggtgccgttttttctattactccaag atttctctattacattccatgtctaatgtg
    Mapping_target: F26D11
    Type_of_mutation: Substitution: c t
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004251
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00000488
    Transcript: F26D11.10a.1 (12)
      F26D11.10d.1 (12)
      F26D11.10c.1 (12)
      F26D11.10b.1 (12)
  Genetics: Interpolated_map_position: V 0.98683
  Description: Phenotype: WBPhenotype:0000229 Paper_evidence: WBPaper00000214
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Worms are smaller than WT. Paper_evidence: WBPaper00000214
            Curator_confirmed: WBPerson712
      WBPhenotype:0000247 Paper_evidence: WBPaper00000214
          WBPaper00042411
        Curator_confirmed: WBPerson712
          WBPerson2987
        Remark: Worms are 35% responsive to Na+ in behavior orientation assay. WT worms are 95% responsive (based on sustained distance from attractant). Paper_evidence: WBPaper00000214
            Curator_confirmed: WBPerson712
          Figure 6B Paper_evidence: WBPaper00042411
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00004782 Paper_evidence: WBPaper00042411
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0006935 PATO:0000460 Paper_evidence: WBPaper00042411
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000254 Paper_evidence: WBPaper00000214
          WBPaper00042411
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson2987
        Remark: Worms swim away from attractant in a gradient selection assay and are 25% responsive to Cl- in behavior orientation assay (based on sustained distance from attractant), WT are 70% responsive. Paper_evidence: WBPaper00000214
            Curator_confirmed: WBPerson712
          non-chemotactic to chloride ion Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          Figure 6B Paper_evidence: WBPaper00042411
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00001360 Paper_evidence: WBPaper00042411
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0006935 PATO:0000460 Paper_evidence: WBPaper00042411
                Curator_confirmed: WBPerson2987
        Ease_of_scoring: ES1_Very_hard_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001057 Paper_evidence: WBPaper00042411
        Curator_confirmed: WBPerson2987
        Remark: Figure 6B Paper_evidence: WBPaper00042411
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00003974 Paper_evidence: WBPaper00042411
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0006935 PATO:0000460 Paper_evidence: WBPaper00042411
                Curator_confirmed: WBPerson2987
      WBPhenotype:0001084 Paper_evidence: WBPaper00042411
        Curator_confirmed: WBPerson2987
        Remark: Figure 6B Paper_evidence: WBPaper00042411
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00042411
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0006935 PATO:0000460 Paper_evidence: WBPaper00042411
                Curator_confirmed: WBPerson2987
      WBPhenotype:0001438 Paper_evidence: WBPaper00001786
        Curator_confirmed: WBPerson2021
        Remark: Defective in chemotaxis to volatile odorants including benzaldehyde, 2-butanone and isoamyl alcohol (Data not shown). Paper_evidence: WBPaper00001786
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00001786
                Curator_confirmed: WBPerson2021
    Phenotype_not_observed: WBPhenotype:0000637 Paper_evidence: WBPaper00000214
        Curator_confirmed: WBPerson712
      WBPhenotype:0001660 Paper_evidence: WBPaper00006052
        Curator_confirmed: WBPerson2021
        Remark: No disruption of ASE asymmetry (as seen with lim-6 reporters) Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: otIs114, otIs6 Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
      WBPhenotype:0002535 Paper_evidence: WBPaper00000932
        Curator_confirmed: WBPerson712
        Remark: FITC uptake is normal. Paper_evidence: WBPaper00000932
            Curator_confirmed: WBPerson712
  Reference: WBPaper00000932
    WBPaper00006052
    WBPaper00001786
    WBPaper00000214
    WBPaper00042411
    WBPaper00064927
  Method: Substitution_allele