WormBase Tree Display for Variation: WBVar00143765

WBVar00143765 Name: Public_name: e1126
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004250
      WBStrain00022728
      WBStrain00022733
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00000487
  Description: Phenotype: WBPhenotype:0000127 Paper_evidence: WBPaper00000214
        Curator_confirmed: WBPerson712
      WBPhenotype:0000247 Paper_evidence: WBPaper00000214
          WBPaper00042411
        Curator_confirmed: WBPerson712
          WBPerson2987
        Remark: Worms are 30% responsive to Na+ in behavior orientation assay. WT worms are 95% responsive (based on sustained distance from attractant). Paper_evidence: WBPaper00000214
            Curator_confirmed: WBPerson712
          "We confirmed that che-6 mutant animals are defective in salt chemotaxis as determined by our chemotaxis assay system (Figure 8C)." Paper_evidence: WBPaper00042411
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00004782 Paper_evidence: WBPaper00042411
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0006935 PATO:0000460 Paper_evidence: WBPaper00042411
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000254 Paper_evidence: WBPaper00000214
          WBPaper00042411
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson2987
        Remark: Worms swim away from attractant in a gradient selection assay and are 20% responsive to Cl- in behavior orientation assay (based on sustained distance from attractant), WT are 70% responsive. Paper_evidence: WBPaper00000214
            Curator_confirmed: WBPerson712
          non-chemotactic to chloride ion Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          Figure 8A, 8B, 8C; "We confirmed that che-6 mutant animals are defective in salt chemotaxis as determined by our chemotaxis assay system (Figure 8C)." Paper_evidence: WBPaper00042411
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00001360 Paper_evidence: WBPaper00042411
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0006935 PATO:0000460 Paper_evidence: WBPaper00042411
                Curator_confirmed: WBPerson2987
        Ease_of_scoring: ES1_Very_hard_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001084 Paper_evidence: WBPaper00042411
        Curator_confirmed: WBPerson2987
        Remark: "We confirmed that che-6 mutant animals are defective in salt chemotaxis as determined by our chemotaxis assay system (Figure 8C)." Paper_evidence: WBPaper00042411
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00003571 Paper_evidence: WBPaper00042411
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0006935 PATO:0000460 Paper_evidence: WBPaper00042411
                Curator_confirmed: WBPerson2987
      WBPhenotype:0001526 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: abnormal IL2 basal bodies Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005118 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
      WBPhenotype:0001532 Paper_evidence: WBPaper00000214
        Curator_confirmed: WBPerson712
        Remark: Abnormal basal body formation of Inner labial type 2 neuron; occasional lack of entire nerve tip. Paper_evidence: WBPaper00000214
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000256 Paper_evidence: WBPaper00000214
        Curator_confirmed: WBPerson712
      WBPhenotype:0000302 Paper_evidence: WBPaper00042411
        Curator_confirmed: WBPerson2987
        Remark: "However, we found that che-6 mutants show no defects in AWC-mediated olfactory behavior (Figure 8D) and no defects in thermotaxis behavior (Figure 9; Figure S3)." Paper_evidence: WBPaper00042411
            Curator_confirmed: WBPerson2987
        Affected_by: Molecule: WBMol:00002087 Paper_evidence: WBPaper00042411
              Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0006935 PATO:0000460 Paper_evidence: WBPaper00042411
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000478 Paper_evidence: WBPaper00042411
        Curator_confirmed: WBPerson2987
        Remark: "However, we found that che-6 mutants show no defects in AWC-mediated olfactory behavior (Figure 8D) and no defects in thermotaxis behavior (Figure 9; Figure S3)." Paper_evidence: WBPaper00042411
            Curator_confirmed: WBPerson2987
        EQ_annotations: GO_term: GO:0043052 PATO:0000460 Paper_evidence: WBPaper00042411
                Curator_confirmed: WBPerson2987
      WBPhenotype:0001438 Paper_evidence: WBPaper00001786
        Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00001786
                Curator_confirmed: WBPerson2021
      WBPhenotype:0001660 Paper_evidence: WBPaper00006052
        Curator_confirmed: WBPerson2021
        Remark: No disruption of ASE asymmetry (as seen with lim-6 reporters) Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: otIs114, otIs6 Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
      WBPhenotype:0002535 Paper_evidence: WBPaper00000932
        Curator_confirmed: WBPerson712
        Remark: FITC uptake is normal. Paper_evidence: WBPaper00000932
            Curator_confirmed: WBPerson712
  Reference: WBPaper00000932
    WBPaper00029016
    WBPaper00006052
    WBPaper00001786
    WBPaper00000214
    WBPaper00042411
    WBPaper00064927
  Method: Allele