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WormBase Tree Display for Variation: WBVar00143737

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Name Class

WBVar00143737EvidencePaper_evidenceWBPaper00001553
NamePublic_namee1095
Other_nameC15F1.3c.1:c.604C>T
CE23546:p.Gln1290Ter
CE43762:p.Gln202Ter
C15F1.3a.1:c.3868C>T
HGVSgCHROMOSOME_II:g.6956179G>A
Sequence_detailsSMapS_parentSequenceC15F1
Flanking_sequencestctcgaaacattgaaaagatgaagaagtcgaagaaaatttggacaaagaaaagagtgaag
Mapping_targetC15F1
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00001553
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00004405
WBStrain00004576
WBStrain00004579
WBStrain00004581
LaboratoryCB
StatusLive
AffectsGeneWBGene00006605
TranscriptC15F1.3a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScC15F1.3a.1:c.3868C>T
HGVSpCE23546:p.Gln1290Ter
cDNA_position3868
CDS_position3868
Protein_position1290
Exon_number23/24
Codon_changeCaa/Taa
Amino_acid_changeQ/*
C15F1.3c.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScC15F1.3c.1:c.604C>T
HGVSpCE43762:p.Gln202Ter
cDNA_position604
CDS_position604
Protein_position202
Exon_number3/3
Codon_changeCaa/Taa
Amino_acid_changeQ/*
InteractorWBInteraction000052137
WBInteraction000052144
WBInteraction000052147
WBInteraction000052158
WBInteraction000052159
WBInteraction000052160
WBInteraction000052161
WBInteraction000052162
WBInteraction000524196
GeneticsInterpolated_map_positionII0.150823
Mapping_dataIn_multi_point843
1471
1473
2311
DescriptionPhenotypeWBPhenotype:0000073Paper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
RemarkAbnormal bursa morphology in pseudomales . Variable reductions or abnormalities in structures such as the bursal fan, sensory rays and spicules.Paper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
WBPhenotype:0000184Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
Remarktra-2/dypunc XX hermaphrodites were competent for both physiological and checkpoint-activated apoptosis, but no apoptosis was observed in N2 X0 and tra-2/tra-2 XX males under either condition.Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
WBPhenotype:0000436Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
RemarkIn tra-2 XX male mutant germ lines, RAD-51 foci progression and abundance mirrored N2 XX hermaphrodite germ lines.Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
WBPhenotype:0000640Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarke1095/+ is Egl hermaphrodite.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Semi_dominantPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000647Paper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
RemarkXX pseudomales do not matePaper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
WBPhenotype:0000648Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkX0 phenotype wildtype male. X0 male mating always successful (ME3); XX transformed males never successful (ME0).Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Semi_dominantPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001025Paper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
RemarkPseudomales have a variable number of catecholamine cells. Pseudomales also have a set of diagonal muscles (that are normally present only in adult males).Paper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
WBPhenotype:0001277Paper_evidenceWBPaper00000178
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
RemarkXX animals are phenotypically malePaper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
XX animals transformed into infertile males with abnormal tail anatomy; gonad morphology male, normal spermatogenesis.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
Semi_dominantPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES3_Easy_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001355Paper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
RemarkFeulgen-stained preparations show that gonads are abnormal in the XX pseudomalesPaper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00000178
Curator_confirmedWBPerson2021
WBPhenotype:0001824Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
RemarkProphase progression timing of tra-2(lf) XX males was similar to N2 X0 males with prophase completed by 20-24 hr; progression of nuclei through each substage was similar to N2 X0 males, although there were fewer labeled nuclei in thetransition zone in tra-2(lf) XX compared to N2 X0 males.Paper_evidenceWBPaper00035521
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000424Paper_evidenceWBPaper00028730
Curator_confirmedWBPerson712
Remarknuclei of loss-of-function mutant tra-2 (e1095) and wild-type male were scarcely immunostained with anti-TRA-2 ICD antibodyPaper_evidenceWBPaper00028730
Curator_confirmedWBPerson712
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00028730
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00028730
Curator_confirmedWBPerson712
WBPhenotype:0001236Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
RemarkAnimals did not differ significantly in the levels of expression of speramtheca and sheath reporter transgenes, fkh-6::GFP and lim-7::GFP.Paper_evidenceWBPaper00036019
Curator_confirmedWBPerson712
Reference (13)
MethodSubstitution_allele