WormBase Tree Display for Variation: WBVar00143682

WBVar00143682 Name: Public_name: e1017
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00003976
      WBStrain00003984
      WBStrain00004229
      WBStrain00027090
      WBStrain00034370
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00006874
    Interactor: WBInteraction000538627
  Genetics: Mapping_data: In_2_point: 235
        1726
      In_multi_point (15)
      In_pos_neg_data: 1727
        1728
        1729
        6868
  Description: Phenotype: WBPhenotype:0000232 Paper_evidence: WBPaper00024898
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson2987
        Remark: failure of posterior migration of CAN cells; rare animals have none correctly placed CAN cell. Similar phenotypes in e1017/Df. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          Table 1 Paper_evidence: WBPaper00024898
            Curator_confirmed: WBPerson2987
        Penetrance: High: 98 Paper_evidence: WBPaper00024898
              Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006827 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
          Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
          GO_term: GO:0016477 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: From Table 1 legend: "A CAN was scored as defective if its nucleus was anterior to the V3 nucleus." Paper_evidence: WBPaper00024898
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000469 Paper_evidence: WBPaper00024898
        Curator_confirmed: WBPerson2987
        Remark: Table 1 Paper_evidence: WBPaper00024898
            Curator_confirmed: WBPerson2987
        Penetrance: Incomplete: 32 Paper_evidence: WBPaper00024898
              Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0004991 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
            WBbt:0003832 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
          Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
          GO_term: GO:0016477 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: From Table 1 legend: "Because they occupy positions near each other, the data for SDQR and AVM were combined and are presented in the QR column. SDQR and AVM were scored as defective if their nuclei were posterior to the V2.a nucleus. The position of AQR, a third QR descendant, was not included because it migrates to a location near other nuclei with similar morphology." Paper_evidence: WBPaper00024898
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000470 Paper_evidence: WBPaper00024898
        Curator_confirmed: WBPerson2987
        Remark: "In vab-8 mutant hermaphrodites, the CANs usually are located in the head, and ~20% of the HSNs migrate beyond their normal destinations (Figure 3; Table 1; Manser and Wood 1990; Wightman et al. 1996; Forrester and Garriga 1997)." Paper_evidence: WBPaper00024898
            Curator_confirmed: WBPerson2987
        Penetrance: Incomplete: 20 Paper_evidence: WBPaper00024898
              Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006830 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
          Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
          GO_term: GO:0016477 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: From Table 1 legend: "Because the HSNs were sometimes misplaced anteriorly and at other times were misplaced posteriorly, we present the data for both phenotypes. An HSN was scored as misplaced anteriorly if its nucleus was anterior to the P5/6 nucleus and as misplaced posteriorly if its nucleus was posterior to the V4 nucleus." Paper_evidence: WBPaper00024898
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000787 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: posterior half uncoordinated, rare animals have normal posterior morphology. Similar phenotypes in e1017/Df. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000794 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: posterior half thin, rare animals have normal posterior morphology. Similar phenotypes in e1017/Df. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000796 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: posterior half pale, rare animals have normal posterior morphology. Similar phenotypes in e1017/Df. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001297 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: adult male tail anatomy vestigial, rare animals have normal posterior morphology. Similar phenotypes in e1017/Df. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000469 Paper_evidence: WBPaper00024898
        Curator_confirmed: WBPerson2987
        Remark: Table 1 Paper_evidence: WBPaper00024898
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0004993 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
            WBbt:0004086 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
          Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
          GO_term: GO:0016477 PATO:0000460 Paper_evidence: WBPaper00024898
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: From Table 1 legend: "Because QL descendants sometimes were misplaced anteriorly and at other times were misplaced posteriorly, we present the data for both phenotypes. A QL cell descendant was scored as misplaced anteriorly if its nucleus was anterior to V4.p and misplaced posteriorly if its nucleus was posterior to V5.p. Because they occupy positions near each other, the data for SDQL and PVM were combined." Paper_evidence: WBPaper00024898
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000792 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: anterior half normal Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001524 Paper_evidence: WBPaper00036308
        Curator_confirmed: WBPerson2987
        Remark: 0% of vab-8(e1017) animals were resistant to EGF-induced sleep (Table 1) Paper_evidence: WBPaper00036308
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Animals carrying the hs:LIN-3 transgene were well fed and grown at 20C. Young adult animals were scored 2 hours after heat shock for EGF-induced sleep behavior (see Materials and methods). Paper_evidence: WBPaper00036308
              Curator_confirmed: WBPerson2987
          Genotype: hs:LIN-3 Paper_evidence: WBPaper00036308
              Curator_confirmed: WBPerson2987
      WBPhenotype:0001652 Paper_evidence: WBPaper00032446
        Curator_confirmed: WBPerson2021
      WBPhenotype:0001660 Paper_evidence: WBPaper00006052
        Curator_confirmed: WBPerson2021
        Remark: No disruption of ASE asymmetry (as seen with lim-6 reporters) Paper_evidence: WBPaper00006052
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: otIs114, otIs6 Paper_evidence: WBPaper00006052
              Curator_confirmed: WBPerson2021
  Reference (13)
  Method: Allele