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WormBase Tree Display for Variation: WBVar00143653

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Name Class

WBVar00143653NamePublic_namee979
Other_nameCE46852:p.Cys146Tyr
Y55D5A.5c.1:c.437G>A
Y55D5A.5a.1:c.437G>A
CE50204:p.Cys146Tyr
Y55D5A.5d.1:c.296G>A
CE50312:p.Cys99Tyr
CE50158:p.Cys70Tyr
Y55D5A.5e.1:c.209G>A
HGVSgCHROMOSOME_III:g.3017014C>T
Sequence_detailsSMapS_parentSequenceY55D5A
Flanking_sequencesagccgtgtgcctcaatagtcgaaaaacgatcggcccaatcgatattcgaaataggccgtg
Mapping_targetY55D5A
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00006391
LaboratoryCB
StatusLive
AffectsGeneWBGene00000898
TranscriptY55D5A.5e.1 (12)
Y55D5A.5a.1 (12)
Y55D5A.5c.1 (12)
Y55D5A.5d.1 (12)
InteractorWBInteraction000009107
WBInteraction000009108
WBInteraction000052470
WBInteraction000517272
WBInteraction000517275
WBInteraction000517276
WBInteraction000517281
GeneticsInterpolated_map_positionIII-8.03771
DescriptionPhenotypeWBPhenotype:0000012Paper_evidenceWBPaper00000214
WBPaper00031688
Curator_confirmedWBPerson712
RemarkThe severe allele daf-2(e979) forms dauers even at 15 deg C.Paper_evidenceWBPaper00031688
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive21.5Paper_evidenceWBPaper00031688
Curator_confirmedWBPerson712
WBPhenotype:0000242Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
Remarkone daf-2(e979) embryo failed to elongate, beginning just before thetwo-fold stage (Fig. 1C). The failing embryo twitched normally at this stage, indicating that it had functional muscles, butwas unable to elongate past the two-fold length and retracted somewhat over a one hour period. After several hours, blebsappeared at the anterior end of the embryo and it eventually rupturedPaper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
ImageWBPicture0000014948Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0007846PATO:0000460Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
WBPhenotype:0000295Paper_evidenceWBPaper00035504
Curator_confirmedWBPerson712
Remarke979 has thermotolerance at least as high as e1370Paper_evidenceWBPaper00035504
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00035504
Curator_confirmedWBPerson712
WBPhenotype:0000867Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
Remark98.9% of daf-2(e979) embryos reached early elongation midway through embryogenesis (comma stage), 10.6% of embryos arrested without hatching (Fig. 1A)Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
ImageWBPicture0000014948Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
WBPhenotype:0000964Paper_evidenceWBPaper00037649
Curator_confirmedWBPerson712
Remarkstrong resistancePaper_evidenceWBPaper00037649
Curator_confirmedWBPerson712
WBPhenotype:0001990Paper_evidenceWBPaper00035504
Curator_confirmedWBPerson712
Remarkdaf-2 allele e979 has moderate hypoxia resistance similar to that of m596.Paper_evidenceWBPaper00035504
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00035504
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000247Paper_evidenceWBPaper00000214
Curator_confirmedWBPerson712
WBPhenotype:0000254Paper_evidenceWBPaper00000214
Curator_confirmedWBPerson712
WBPhenotype:0001536Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
RemarkAll daf-2(e979) embryos examined showed hypodermal patterning that was similar to wild-type.Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
ImageWBPicture0000014948Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0007846PATO:0000460Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
WBPhenotype:0001566Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
RemarkVentral views (not shown) revealed no difficulties with ventral enclosure and dorsal fusion of hypodermal cells appeared normal.Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
ImageWBPicture0000014948Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0007846PATO:0000460Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
Phenotype_assayTemperature25Paper_evidenceWBPaper00059059
Curator_confirmedWBPerson712
WBPhenotype:0001765Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
RemarkMutants respond normally to CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_assayTreatment10% CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
ReferenceWBPaper00031936
WBPaper00000214
WBPaper00037649
WBPaper00031688
WBPaper00035504
WBPaper00059059
RemarkAllele e979 is cited in WBPaper00005310. A subsequent erratum explains that the strain was incorrectly referred to as daf-2(e979) but was infact daf-2(m41).Curator_confirmedWBPerson2970
MethodSubstitution_allele