WormBase Tree Display for Variation: WBVar00143530

WBVar00143530 Name: Public_name: e840
    Other_name: eDf44
  Sequence_details: Mapping_target: R160
    Type_of_mutation: Deletion
    SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004207
      WBStrain00004457
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00001082
    Interactor (13)
  Isolation: Mutagen: X-ray
  Genetics: Mapping_data: In_2_point: 475
      In_multi_point: 357
        358
        359
        646
        1588
        2228
  Description: Phenotype (14)
    Phenotype_not_observed: WBPhenotype:0000134 Paper_evidence: WBPaper00031356
        Curator_confirmed: WBPerson712
        Remark: EGL-20/Wnt was expressed at similar levels to those observed for wild type and mig-14 animals as assayed by expression of the rescuing translational GFP reporter, muIs49. Paper_evidence: WBPaper00031356
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: muIs49[egl-20::gfp] Paper_evidence: WBPaper00031356
              Curator_confirmed: WBPerson712
      WBPhenotype:0000436 Paper_evidence: WBPaper00042286
        Curator_confirmed: WBPerson712
        Remark: In apm-2 mutants, tagged alpha-adaptin is still localized to the synapse and the plasma membrane of coelomocytes. Tagged sigma 2-adaptin is still localized to the nerve ring. Tagged beta subunit fluorescence is visible in cell bodies in apm-2mutants; however, it is no longer detectable in the synapse-rich region of the nerve ring in the absence of mu2-adaptin. Paper_evidence: WBPaper00042286
            Curator_confirmed: WBPerson712
      WBPhenotype:0000679 Paper_evidence: WBPaper00028448
        Curator_confirmed: WBPerson712
        Remark: Mutations in the AP-2 and AP-3 complex do not obviously affect PKD-2 dendritic or ciliary localization. Paper_evidence: WBPaper00028448
            Curator_confirmed: WBPerson712
      WBPhenotype:0000706 Paper_evidence: WBPaper00025094
        Curator_confirmed: WBPerson2021
        Remark: No obvious gut granule defects Paper_evidence: WBPaper00025094
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Staining with LysoTracker Red and acridine orange Paper_evidence: WBPaper00025094
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001323 Paper_evidence: WBPaper00042286
        Curator_confirmed: WBPerson712
        Remark: An accumulation of large vesicles at mutant synapses is not apparent in contrast to alpha-adaptin mutant synapses. Paper_evidence: WBPaper00042286
            Curator_confirmed: WBPerson712
  Reference: WBPaper00022318
    WBPaper00042286
    WBPaper00015167
    WBPaper00028448
    WBPaper00025094
    WBPaper00031356
    WBPaper00015055
    WBPaper00023077
    WBPaper00065262
  Remark: e840 is a 100kb deletion which removes 18 ORFs from col-165 to F25F6.1 Person_evidence: WBPerson3426
  Method: Deletion_allele