WormBase Tree Display for Variation: WBVar00143390
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| WBVar00143390 | Name | Public_name | e669su250 | |||||
|---|---|---|---|---|---|---|---|---|
| Sequence_details | SeqStatus | Pending_curation | ||||||
| Variation_type | Allele | |||||||
| Origin | Species | Caenorhabditis elegans | ||||||
| Laboratory | CB | |||||||
| HE | ||||||||
| Status | Live | |||||||
| Linked_to | WBVar00143389 | |||||||
| WBVar00248864 | ||||||||
| Affects | Gene | WBGene00006787 | ||||||
| Interactor | WBInteraction000518977 | |||||||
| WBInteraction000518978 | ||||||||
| WBInteraction000519080 | ||||||||
| WBInteraction000519081 | ||||||||
| WBInteraction000519455 | ||||||||
| WBInteraction000519456 | ||||||||
| WBInteraction000519457 | ||||||||
| WBInteraction000519458 | ||||||||
| WBInteraction000519459 | ||||||||
| WBInteraction000560385 | ||||||||
| Description | Phenotype | WBPhenotype:0000644 | Paper_evidence | WBPaper00044758 | ||||
| Curator_confirmed | WBPerson5063 | |||||||
| Remark | temperature sensitive phenotype rescued by FUdR | Paper_evidence | WBPaper00044758 | |||||
| Curator_confirmed | WBPerson5063 | |||||||
| Temperature_sensitive | Heat_sensitive | 25 | Paper_evidence | WBPaper00044758 | ||||
| Curator_confirmed | WBPerson5063 | |||||||
| WBPhenotype:0001645 | Paper_evidence | WBPaper00040652 | ||||||
| WBPaper00040284 | ||||||||
| Curator_confirmed | WBPerson712 | |||||||
| WBPerson2987 | ||||||||
| Remark | Acute temperature shift of fully developed adult animals results in protein degradation in mutants but not in wild-type animals. | The same temperature shift experiments in the presence of the protein synthesis inhibitor cycloheximide (CHx) showed that degradation was occurring by activation of pre-existing protease(s). | Degradation was not prevented by treatment with levamisole (Lev), MG132 (ZLLL), SB201290, or N6,N6-dimethyladenosine. | Acute treatment with calpain inhibitors did suppress protein degradation. | Paper_evidence | WBPaper00040652 | |||||
| Curator_confirmed | WBPerson712 | |||||||
| Table 1 | Paper_evidence | WBPaper00040284 | ||||||
| Curator_confirmed | WBPerson2987 | |||||||
| Affected_by | Molecule | WBMol:00004019 | Paper_evidence | WBPaper00040652 | ||||
| Curator_confirmed | WBPerson712 | |||||||
| WBMol:00005300 | Paper_evidence | WBPaper00040652 | ||||||
| Curator_confirmed | WBPerson712 | |||||||
| WBMol:00005301 | Paper_evidence | WBPaper00040652 | ||||||
| Curator_confirmed | WBPerson712 | |||||||
| WBMol:00005302 | Paper_evidence | WBPaper00040652 | ||||||
| Curator_confirmed | WBPerson712 | |||||||
| WBMol:00005303 | Paper_evidence | WBPaper00040652 | ||||||
| Curator_confirmed | WBPerson712 | |||||||
| Temperature_sensitive | Heat_sensitive | Paper_evidence | WBPaper00040652 | |||||
| Curator_confirmed | WBPerson712 | |||||||
| Reference | WBPaper00040284 | |||||||
| WBPaper00040652 | ||||||||
| WBPaper00014786 | ||||||||
| WBPaper00014522 | ||||||||
| WBPaper00044758 | ||||||||
| Remark | Cis double mutant | |||||||
| Method | Allele |
