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WormBase Tree Display for Variation: WBVar00143206

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Name Class

WBVar00143206EvidencePaper_evidenceWBPaper00004275
NamePublic_namee429
Other_nameCE28239:p.Asp819Asn
JC8.10a.1:c.2455G>A
JC8.10b.1:c.2473G>A
CE29050:p.Asp825Asn
HGVSgCHROMOSOME_IV:g.13263902C>T
Sequence_detailsSMapS_parentSequenceJC8
Flanking_sequencesagctatgatagatcagaattaaaaacttctatcatcgacctgttggagctgttttcaaag
Mapping_targetJC8
Type_of_mutationSubstitutionga
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryCB
StatusLive
AffectsGeneWBGene00006763
TranscriptJC8.10b.1 (12)
JC8.10a.1 (12)
GeneticsInterpolated_map_positionIV8.51123
DescriptionPhenotypeWBPhenotype:0000017Paper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
RemarkWeak allele. unc-26 mutants are resistant to inhibitors of acetylcholinesterase, indicative of a decrease in acetylcholine release.Paper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
WBPhenotype:0000210Paper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
RemarkWeak allele. unc-26 mutants have reduced numbers of enteric muscle contractions, indicative of GABAergic function.Paper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
WBPhenotype:0000229Paper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
RemarkWeak allele. unc-26 mutants resemble mutants lacking the biosynthetic enzyme for acetylcholine encoded by the cha-1 gene; animals are small.Paper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
WBPhenotype:0000455Paper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
RemarkWeak allele. unc-26 mutants resemble mutants lacking the biosynthetic enzyme for acetylcholine encoded by the cha-1 gene; animals move backwards with a jerky motionPaper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
WBPhenotype:0000565Paper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
RemarkWeak allele. unc-26 mutants resemble mutants lacking the biosynthetic enzyme for acetylcholine encoded by the cha-1 gene; frequently coil.Paper_evidenceWBPaper00004275
Curator_confirmedWBPerson712
WBPhenotype:0000643Paper_evidenceWBPaper00001303
Curator_confirmedWBPerson712
RemarkAnimals exhibited limited movement in the first two larval stages but it progressively improved with age. As adults, animals were capable of moving in sinusoidal patterns over shot distances.Paper_evidenceWBPaper00001303
Curator_confirmedWBPerson712
ReferenceWBPaper00004275
WBPaper00013791
WBPaper00001303
MethodSubstitution_allele