WormBase Tree Display for Variation: WBVar00143072

WBVar00143072 Name: Public_name: e264
    Other_name: CE24908:p.Trp5Ter
      F21F3.5.1:c.15G>A
    HGVSg: CHROMOSOME_I:g.4900886C>T
  Sequence_details: SMap: S_parent: Sequence: F21F3
    Flanking_sequences: aatacttaaaaaaaagatgcgctctttttg ttattccttttactgttattattttgcatc
    Mapping_target: F21F3
    Type_of_mutation: Substitution: g a Person_evidence: WBPerson22169
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00004213
      WBStrain00030692
    Laboratory: CB
    Status: Live
  Affects (2)
  Isolation: Reverse_genetics: PCR
  Genetics: Interpolated_map_position: I -0.647852
    Mapping_data: In_multi_point: 969
        1787
        1788
        2092
      In_pos_neg_data: 332
  Description: Phenotype: WBPhenotype:0000002 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: weak kinker Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000164 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0000324 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0000421 Paper_evidence: WBPaper00000031
          WBPaper00000484
        Curator_confirmed: WBPerson48
          WBPerson2021
        Remark: Poor viability in 1mM levamisole. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00000031
                WBPaper00000484
              Curator_confirmed: WBPerson48
                WBPerson2021
        Phenotype_assay: Treatment: 1mM levamisole Paper_evidence: WBPaper00000484
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000545 Paper_evidence: WBPaper00000484
        Curator_confirmed: WBPerson2021
        Remark: Mutants have the unhealthy tendency to accumulate eggs. Paper_evidence: WBPaper00000484
            Curator_confirmed: WBPerson2021
      WBPhenotype:0000554 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: sensitive to hypoosmotic shock Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000562 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: resistant to 1mM levamisole in body but not in head Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Affected_by: Molecule: WBMol:00004019 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000583 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: slightly dumpyish Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000640 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: sometimes Egl Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00000031
          WBPaper00000484
          WBPaper00041959
        Curator_confirmed: WBPerson48
          WBPerson2021
          WBPerson557
        Remark: Exhibited significantly reduced general locomotor activity compared to control worms. Paper_evidence: WBPaper00041959
            Curator_confirmed: WBPerson557
      WBPhenotype:0000646 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
      WBPhenotype:0001315 Paper_evidence: WBPaper00029130
        Curator_confirmed: WBPerson14391
        Remark: No levamisole-AChR activity observed in isolated muscle cells Paper_evidence: WBPaper00029130
            Curator_confirmed: WBPerson14391
      WBPhenotype:0001639 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0001645 Paper_evidence: WBPaper00004117
        Curator_confirmed: WBPerson1754
        Remark: Increased levels of protein degradation in muscle in response to starvation Paper_evidence: WBPaper00004117
            Curator_confirmed: WBPerson1754
      WBPhenotype:0001716 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0001852 Paper_evidence: WBPaper00035074
        Curator_confirmed: WBPerson2021
        Remark: Mutants are resistant to tribendimidine Paper_evidence: WBPaper00035074
            Curator_confirmed: WBPerson2021
      WBPhenotype:0002256 Paper_evidence: WBPaper00041069
        Curator_confirmed: WBPerson1754
        Remark: Increased sensitivity to movement decline in response to selenium exposure Paper_evidence: WBPaper00041069
            Curator_confirmed: WBPerson1754
        Affected_by: Molecule: WBMol:00001915 Paper_evidence: WBPaper00041069
              Curator_confirmed: WBPerson1754
      WBPhenotype:0002284 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002288 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002293 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002295 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002300 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002301 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002308 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002312 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002323 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002336 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002344 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0002347 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0004022 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
      WBPhenotype:0004023 Paper_evidence: WBPaper00043908
        Curator_confirmed: WBPerson2987
    Phenotype_not_observed: WBPhenotype:0001645 Paper_evidence: WBPaper00040284
        Curator_confirmed: WBPerson2987
        Remark: Table S2 Paper_evidence: WBPaper00040284
            Curator_confirmed: WBPerson2987
      WBPhenotype:0001853 Paper_evidence: WBPaper00035150
        Curator_confirmed: WBPerson2021
        Remark: Mutant response to AAD 1470 was comparable to that observed in wild-type Paper_evidence: WBPaper00035150
            Curator_confirmed: WBPerson2021
  Reference: WBPaper00040284
    WBPaper00041069
    WBPaper00041959
    WBPaper00043908
    WBPaper00029130
    WBPaper00035074
    WBPaper00000031
    WBPaper00004117
    WBPaper00035150
    WBPaper00000484
  Remark: Manually curated Gene associations preserved as a text remark so that VEP is the canonical predictor of consequence: WBGene00006774 Opal_UGA W(5) to stop
  Method: Substitution_allele