WormBase Tree Display for Variation: WBVar00095124

WBVar00095124 Evidence: Paper_evidence: WBPaper00004879
  Name: Public_name: p767
    Other_name: Y113G7A.6a.1:c.129+1G>A
      Y113G7A.6c.1:c.18+1G>A
      Y113G7A.6b.1:c.129+1G>A
      Y113G7A.6d.1:c.93+1G>A
    HGVSg: CHROMOSOME_V:g.20059673C>T
  Sequence_details: SMap: S_parent: Sequence: Y113G7A
    Flanking_sequences: ggatcaactacaatgaacagcggaaatttt tgggttttttaaaattaaatttttttcagt
    Mapping_target: Y113G7A
    Type_of_mutation: Substitution: g a
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00030792
    Laboratory: PR
    Status: Live
  Affects: Gene: WBGene00006652
    Transcript: Y113G7A.6c.1 VEP_consequence: splice_donor_variant
        VEP_impact: HIGH
        HGVSc: Y113G7A.6c.1:c.18+1G>A
        Intron_number: 1/7
      Y113G7A.6a.1 VEP_consequence: splice_donor_variant
        VEP_impact: HIGH
        HGVSc: Y113G7A.6a.1:c.129+1G>A
        Intron_number: 3/10
      Y113G7A.6b.1 VEP_consequence: splice_donor_variant
        VEP_impact: HIGH
        HGVSc: Y113G7A.6b.1:c.129+1G>A
        Intron_number: 2/8
      Y113G7A.6d.1 VEP_consequence: splice_donor_variant
        VEP_impact: HIGH
        HGVSc: Y113G7A.6d.1:c.93+1G>A
        Intron_number: 2/9
    Interactor (13)
  Genetics: Interpolated_map_position: V 24.5218
    Mapping_data: In_multi_point: 4745
  Description: Phenotype: WBPhenotype:0000997 Paper_evidence: WBPaper00035614
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
        Remark: ttx-1 mutants showed a strong tendency to migrate toward the cold area of the temperature gradient, regardless of the conditioning temperature Paper_evidence: WBPaper00035614
            Curator_confirmed: WBPerson2021
          mutant animals strongly cryophilic Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001273 Paper_evidence: WBPaper00031874
        Curator_confirmed: WBPerson2021
        Remark: Mutations affecting the AFD or AIY neurons reduced heat shock-dependent accumulation of hsp70 (C12C8.1) mRNA at 30C and 34C Paper_evidence: WBPaper00031874
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Animals were exposed to a transient increase in temperature (30C or 34C for 15 min), and their heat shock response was measured as the total amount of hsp70 (C12C8.1) mRNA, 2 hours after heat shock Paper_evidence: WBPaper00031874
              Curator_confirmed: WBPerson2021
      WBPhenotype:0002088 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: hypersensitive to dauer pheromone Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          neuron AFD lacks "fingers" (microvilli) Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005662 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000238 Paper_evidence: WBPaper00035327
        Curator_confirmed: WBPerson2021
        Remark: ttx-1(AFD) did not show any significant phenotype for roaming behavior Paper_evidence: WBPaper00035327
            Curator_confirmed: WBPerson2021
      WBPhenotype:0001765 Paper_evidence: WBPaper00031936
        Curator_confirmed: WBPerson2021
        Remark: Mutants respond normally to CO2 Paper_evidence: WBPaper00031936
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00031936
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 10% CO2 Paper_evidence: WBPaper00031936
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00031936
    WBPaper00031874
    WBPaper00035327
    WBPaper00015583
    WBPaper00014724
    WBPaper00011136
    WBPaper00020867
    WBPaper00035614
    WBPaper00061932
  Method: Substitution_allele