WormBase Tree Display for Variation: WBVar00094610

WBVar00094610 Evidence: Paper_evidence: WBPaper00004137
  Name: Public_name: om18
    Other_name: F26A3.3.1:c.790-1G>A
    HGVSg: CHROMOSOME_I:g.7655270C>T
  Sequence_details: SMap: S_parent: Sequence: F26A3
    Flanking_sequences: atcgaaataagatgttaattacaattttca gaaaatcggcactccgtcccacattatcga
    Mapping_target: F26A3
    Type_of_mutation: Substitution: g a
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Laboratory: EL
    Status: Live
  Affects: Gene: WBGene00001214
    Transcript: F26A3.3.1 VEP_consequence: splice_acceptor_variant
        VEP_impact: HIGH
        HGVSc: F26A3.3.1:c.790-1G>A
        Intron_number: 5/16
    Interactor: WBInteraction000518988
  Genetics: Interpolated_map_position: I 2.21448
    Mapping_data: In_multi_point: 3349
        3350
        3351
        3352
        3353
  Description: Phenotype: WBPhenotype:0000356 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: delayed spermatogenesis Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000684 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: reduced germ cell number, 50% of wild type in young adult Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000894 Paper_evidence: WBPaper00004137
        Curator_confirmed: WBPerson2021
        Remark: In ego-1 animals, transition nuclei were visible several hours earlier than in controls Paper_evidence: WBPaper00004137
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00004137
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004137
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00004137
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: DAPI staining Paper_evidence: WBPaper00004137
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001260 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: abnormal unfertilized oocytes Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001567 Paper_evidence: WBPaper00004137
        Curator_confirmed: WBPerson2021
        Remark: ego-1 mutants had large, diffusely staining nuclei in the distal arm of the gonad that were not found in controls Paper_evidence: WBPaper00004137
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00004137
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004137
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00004137
                Curator_confirmed: WBPerson2021
            WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00004137
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: DAPI staining Paper_evidence: WBPaper00004137
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001694 Paper_evidence: WBPaper00004137
        Curator_confirmed: WBPerson2021
        Remark: The spermatogenesis-to-oogenesis switch occurred several hours later in ego-1 mutants than in controls Paper_evidence: WBPaper00004137
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00004137
          Curator_confirmed: WBPerson2021
        Variation_effect: Probable_null_via_phenotype: Paper_evidence: WBPaper00004137
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00004137
                Curator_confirmed: WBPerson2021
  Reference: WBPaper00004137
    WBPaper00022067
    WBPaper00011141
    WBPaper00015554
    WBPaper00010940
    WBPaper00015000
  Method: Substitution_allele