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WormBase Tree Display for Variation: WBVar00091664

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Name Class

WBVar00091664NamePublic_nameok367
Other_nameR01E6.4a.1:c.592+19_1356+5del
R01E6.4b.1:c.319+19_1083+5del
HGVSgCHROMOSOME_X:g.13534147_13535514del
Sequence_detailsSMapS_parentSequenceR01E6
Flanking_sequencesaacttccacaaggtaaattcagctgggctgtagacagtggtttcttaaaaactacaagta
Mapping_targetR01E6
Type_of_mutationDeletion
PCR_productOK367_external
OK367_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00035572
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00000051
TranscriptR01E6.4a.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScR01E6.4a.1:c.592+19_1356+5del
Intron_number6-11/13
Exon_number7-11/14
R01E6.4b.1VEP_consequencesplice_acceptor_variant,splice_donor_variant,coding_sequence_variant,intron_variant
VEP_impactHIGH
HGVScR01E6.4b.1:c.319+19_1083+5del
Intron_number4-9/10
Exon_number5-9/11
InteractorWBInteraction000562870
GeneticsMapping_dataIn_multi_point4138
DescriptionPhenotypeWBPhenotype:0000016Paper_evidenceWBPaper00042180
Curator_confirmedWBPerson557
RemarkAuthors found the acr-12(ok367) mutation accelerated the time course of aldicarb-induced paralysis. Note: Authors showed that specific expression of acr-12 in GABA neurons restored wild-type sensitivity to aldicarb.Paper_evidenceWBPaper00042180
Curator_confirmedWBPerson557
Phenotype_assayTreatmentStaged populations of adult animals were transferred to nematode growth medium plates containing 1 mM aldicarb and movement was assessed every 15 minutes for 2 hours.Paper_evidenceWBPaper00042180
Curator_confirmedWBPerson557
WBPhenotype:0001316Paper_evidenceWBPaper00042180
Curator_confirmedWBPerson557
Remarkacr-12(ok367) mutations significantly reduced the rate of endogenous excitatory postsynaptic currents (EPSCs), but did not affect EPSC amplitude. When recording outward GABA-mediated inhibitory postsynaptic currents (IPSCs) authors also observed a significant reduction in the rate of inhibitory events (IPSCs), but not a significant difference in the amplitude of endogenous IPSCs.Paper_evidenceWBPaper00042180
Curator_confirmedWBPerson557
WBPhenotype:0002326Paper_evidenceWBPaper00042180
Curator_confirmedWBPerson557
WBPhenotype:0004018Paper_evidenceWBPaper00042180
Curator_confirmedWBPerson557
RemarkThe sinusoidal locomotory wave appeared more erratic in acr-12(ok367) mutants with an increased variability from one body bend to the next.Paper_evidenceWBPaper00042180
Curator_confirmedWBPerson557
Phenotype_not_observedWBPhenotype:0000643Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
WBPhenotype:0000681Paper_evidenceWBPaper00027611
Curator_confirmedWBPerson712
RemarkScored as DMPP sensitive.Paper_evidenceWBPaper00027611
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00000896Paper_evidenceWBPaper00027611
Curator_confirmedWBPerson712
WBPhenotype:0000886Paper_evidenceWBPaper00035548
Curator_confirmedWBPerson712
RemarkAnimals are superficially wild-type, as are acr-2(n2420); acr-12(ok367) double mutant animals.Paper_evidenceWBPaper00035548
Curator_confirmedWBPerson712
WBPhenotype:0001468Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
RemarkMutant worms exhibited a normal approach to a benzaldehyde stimulus.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
Phenotype_assayTreatmentWorms placed on chemotaxis plates spotted with 0.01% benzaldehyde.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
ReferenceWBPaper00041959
WBPaper00027611
WBPaper00035548
WBPaper00026201
WBPaper00042180
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele