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WormBase Tree Display for Variation: WBVar00091493

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Name Class

WBVar00091493NamePublic_nameok180
Sequence_detailsMapping_targetK03F8
SeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00028651
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00000044
InteractorWBInteraction000518505
GeneticsMapping_dataIn_multi_point4136
DescriptionPhenotypeWBPhenotype:0000525Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
RemarkWild-type worms climb the nicotine gradient, that is worms approach the nicotine spot in a time- and concentration dependent manner. These mutants have reduced nicotine approach behavior.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
Phenotype_assayTreatmentWorms placed on a nicotine gradient. The nicotine gradient was formed by adding 10 uL of 50 mm nicotine tartrate salt solution in water and allowed 90 minutes to diffuse.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
WBPhenotype:0001573Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
RemarkWild-type worms climb the nicotine gradient, that is worms approach the nicotine spot in a time- and concentration dependent manner. These mutants have reduced nicotine approach behavior.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
Phenotype_assayTreatmentWorms placed on a nicotine gradient. The nicotine gradient was formed by adding 10 uL of 50 mm nicotine tartrate salt solution in water and allowed 90 minutes to diffuse.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
WBPhenotype:0001780Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
Remarkacr-5 mutants were defective at associating the presence of nicotine with butanone under starvation conditions. Authors demonstrated that worms previously exposed to 50 mM nicotine in the presence of 100% butanone approached 0.5% butanone, whereas worms exposed to plates lacking nicotine in the presence of 100% butanone later avoided 0.5% butanone. acr- 5 mutants, which blocked approach to nicotine, also eliminated the ability of nicotine to preserve approach to butanone by mutants in butanone.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
Phenotype_assayTreatmentAuthors demonstrated that worms previously exposed to 50 mM nicotine in the presence of 100% butanone approached 0.5% butanone, whereas worms exposed to plates lacking nicotine in the presence of 100% butanone later avoided 0.5% butanone.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
Phenotype_not_observedWBPhenotype:0000643Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
WBPhenotype:0000681Paper_evidenceWBPaper00027611
Curator_confirmedWBPerson712
RemarkScored as DMPP sensitive.Paper_evidenceWBPaper00027611
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00000896Paper_evidenceWBPaper00027611
Curator_confirmedWBPerson712
WBPhenotype:0000886Paper_evidenceWBPaper00035548
Curator_confirmedWBPerson712
RemarkAnimals are superficially wild-type.Paper_evidenceWBPaper00035548
Curator_confirmedWBPerson712
WBPhenotype:0001468Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
RemarkMutant worms exhibited a normal approach to a benzaldehyde stimulus.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
Phenotype_assayTreatmentWorms placed on chemotaxis plates spotted with 0.01% benzaldehyde.Paper_evidenceWBPaper00041959
Curator_confirmedWBPerson557
ReferenceWBPaper00041959
WBPaper00027611
WBPaper00035548
RemarkLast updated on 29 Nov 2002
Generated by the C. elegans Gene Knockout Consortium
MethodKO_consortium_allele