WormBase Tree Display for Variation: WBVar00090503

WBVar00090503 Evidence: Paper_evidence: WBPaper00026863
  Name: Public_name: n2515
    Other_name: CE27833:p.Pro344Leu
      CE31440:p.Pro384Leu
      C37F5.1a.1:c.1151C>T
      C37F5.1b.1:c.1031C>T
    HGVSg: CHROMOSOME_IV:g.2276449G>A
  Sequence_details: SMap: S_parent: Sequence: C37F5
    Flanking_sequences: atttctatacttttcaggtgttccaattcc gccggtctccgcattccaggccacaaatcc
    Mapping_target: C37F5
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00003160
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00040576
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00002990
    Transcript: C37F5.1a.1 (12)
      C37F5.1b.1 (12)
    Interactor: WBInteraction000002753
      WBInteraction000002762
      WBInteraction000052120
  Genetics: Interpolated_map_position: IV -8.49948
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: 11% of fertile animals (n=36) exhibited an egg laying defect. Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Penetrance: Incomplete: Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-17(e113) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
      WBPhenotype:0000698 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: 4% animals (n=27) are aberrant in induction of VPCs; <3 of the VPCs, which are induced in wild type animals (P5.p to P7.p), are induced in these animals, as scored by Nomarski optics. Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Penetrance: Low: Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-17(e113) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000054 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Remark: The lin-1(n2515) mutation did not result in rod-like larval lethality Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
      WBPhenotype:0000099 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Remark: The lin-1(n2515) mutation did not induce the "2 P11.p" phenotype where the P12 cell adopts a P11 cell fate Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
      WBPhenotype:0000688 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: 0% animals produced progeny (n=36). Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-17(e113) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
      WBPhenotype:0000698 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
      WBPhenotype:0000700 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: 0% animals display one or more ectopic pseudovulvae (n=131). Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-17(e113) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
      WBPhenotype:0001272 Paper_evidence: WBPaper00026863
          WBPaper00005344
        Curator_confirmed: WBPerson712
          WBPerson2987
        Remark: On average 2.97 VCPs (n=27 animals) are induced to adopt a vulval cell fate, which is near that of wild type, (3/6 VPCs induced n=29). VPCs and fate adoption were scored by Nomarski optics. Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
          The lin-1(n2515) mutation resulted in the expected number (~3) of induced vulval precursor cells Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Variation_effect: Hypermorph_gain_of_function: Paper_evidence: WBPaper00026863
              WBPaper00005344
            Curator_confirmed: WBPerson712
              WBPerson2987
        Phenotype_assay: Treatment: Vulval induction was scored in late L3 to early L4 stage larvae, under Normarski optics. All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
          Genotype: unc-17(e113) Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
  Reference: WBPaper00005344
    WBPaper00026863
  Method: Substitution_allele