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WormBase Tree Display for Variation: WBVar00090168

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Name Class

WBVar00090168NamePublic_namen1437
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryMT
StatusLive
AffectsGeneWBGene00001188
InteractorWBInteraction000538626
WBInteraction000538643
WBInteraction000538645
WBInteraction000538650
WBInteraction000538664
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
Remarkweakly temperature-sensitivePaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
PenetranceIncompletePaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
Range4848Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0000469Paper_evidenceWBPaper00002582
WBPaper00024898
Curator_confirmedWBPerson712
WBPerson2987
RemarkAnimals exhibit severe QL descendant migration defects. Although the migration of QL is posterior, QL descendants reverse direction during migration and migrate anteriorly.Paper_evidenceWBPaper00002582
Curator_confirmedWBPerson712
Table 1, Figure 6Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Table 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
PenetranceIncomplete53Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Complete100Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Haplo_insufficientPaper_evidenceWBPaper00002582
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0004993PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBbt:0004086PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBbt:0004991PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBbt:0003832PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom Table 1 legend: "Because QL descendants sometimes were misplaced anteriorly and at other times were misplaced posteriorly, we present the data for both phenotypes. A QL cell descendant was scored as misplaced anteriorly if its nucleus was anterior to V4.p and misplaced posteriorly if its nucleus was posterior to V5.p. Because they occupy positions near each other, the data for SDQL and PVM were combined."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
From Table 1 legend: "Because they occupy positions near each other, the data for SDQR and AVM were combined and are presented in the QR column. SDQR and AVM were scored as defective if their nuclei were posterior to the V2.a nucleus. The position of AQR, a third QR descendant, was not included because it migrates to a location near other nuclei with similar morphology."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Temperature20Paper_evidenceWBPaper00002582
Curator_confirmedWBPerson712
Genotypemab-5(e2088)/+; egl-20(n585)/+ - nonallelic noncomplementing alleles affect QL.pa daughter positions. Cells are in anterior positions (V1-V3 region).Paper_evidenceWBPaper00002582
Curator_confirmedWBPerson712
WBPhenotype:0000470Paper_evidenceWBPaper00001105
WBPaper00002582
WBPaper00024898
Curator_confirmedWBPerson2021
WBPerson712
WBPerson2987
RemarkHSNs fail to arrive at their final destination (between P5/6 and V4)Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
Animals exhibit severe HSN descendant migration defects.Paper_evidenceWBPaper00002582
Curator_confirmedWBPerson712
In egl-20(n1437) mutants, the HSN cell migrates anteriorly short of (posterior to) its wild type destination (Figure 2, Table 1)Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
PenetranceIncomplete57Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00001105
WBPaper00002582
WBPaper00024898
Curator_confirmedWBPerson2021
WBPerson712
WBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00001105
WBPaper00024898
Curator_confirmedWBPerson2021
WBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom Table 1 legend: "Because the HSNs were sometimes misplaced anteriorly and at other times were misplaced posteriorly, we present the data for both phenotypes. An HSN was scored as misplaced anteriorly if its nucleus was anterior to the P5/6 nucleus and as misplaced posteriorly if its nucleus was posterior to the V4 nucleus."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Genotypemab-5(e2088)/+; egl-20(n585)/+ - nonallelic noncomplementing alleles affect QL.pa daughter positions. Cells are in anterior positions (V1-V3 region).Paper_evidenceWBPaper00002582
Curator_confirmedWBPerson712
WBPhenotype:0001235Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
RemarkAt 25 degrees Celsius, 49% of egl-20(n1437) animals exhibited reversals in the relative positions of the V5 daughter cells. In these animals, the V5.a cell exhibited the morphology of a seam cell and the V5.p cell exhibited the morphology of a syncytial nucleus (Table 1)Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
At 20 degrees Celsius, 4% of egl-20(n1437) animals exhibited reversals in the relative positions of the V5 daughter cells. In these animals, the V5.a cell exhibited the morphology of a seam cell and the V5.p cell exhibited the morphology of a syncytial nucleus (Table 1)Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
At 15 degrees Celsius, 10% of egl-20(n1437) animals exhibited reversals in the relative positions of the V5 daughter cells. In these animals, the V5.a cell exhibited the morphology of a seam cell and the V5.p cell exhibited the morphology of a syncytial nucleus (Table 1)Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
PenetranceIncomplete49% penetrantPaper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
Low4% penetrantPaper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
10% penetrantPaper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004890PATO:0000460Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
WBbt:0004876PATO:0000460Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
WBbt:0004250PATO:0000460Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
WBbt:0007446PATO:0000460Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
WBbt:0004246PATO:0000460Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
WBbt:0007463PATO:0000460Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
Phenotype_assayTemperature25Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
20Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
15Paper_evidenceWBPaper00004436
Curator_confirmedWBPerson2987
WBPhenotype:0001375Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Remarkegl-20(n1437) mutants exhibit a complete loss of expression of the mab-5::GFP transgene in QL descendants (Table 2)Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0004993PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBbt:0004086PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayGenotypemuIs16 [mab-5::GFP]Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000232Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006827PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom Table 1 legend: "A CAN was scored as defective if its nucleus was anterior to the V3 nucleus."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0000471Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005406PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom the Table 1 legend: "An ALM was scored as defective if its nucleus was anterior to the V2 nucleus."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
WBPhenotype:0000594Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
RemarkTable 1Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006826PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Life_stageWBls:0000024PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
GO_termGO:0016477PATO:0000460Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentFrom Table 1 legend: "Because BDUs sometimes were misplaced anteriorly and at other times were misplaced posteriorly, we present the data for both phenotypes. A BDU was scored as misplaced anteriorly if its nucleus was anterior to its normal position immediately anterior to V1 and misplaced posteriorly if its nucleus was posterior to the V1 nucleus."Paper_evidenceWBPaper00024898
Curator_confirmedWBPerson2987
ReferenceWBPaper00024898
WBPaper00004436
WBPaper00001105
WBPaper00002582
MethodAllele