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WormBase Tree Display for Variation: WBVar00089973

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Name Class

WBVar00089973EvidencePaper_evidenceWBPaper00002141
NamePublic_namen1134
Other_nameCE05311:p.Met1?
C26C6.2.1:c.3G>A
HGVSgCHROMOSOME_I:g.7522212G>A
Sequence_detailsSMapS_parentSequenceC26C6
Flanking_sequencesggtccaccgttcatcaactctagcgccatggttgtaccatgtcacaggaagagcgtgcc
Mapping_targetC26C6
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00002141
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00026970
LaboratoryMT
StatusLive
AffectsGeneWBGene00001648
TranscriptC26C6.2.1 (12)
InteractorWBInteraction000501273
WBInteraction000503445
WBInteraction000518668
WBInteraction000542428
WBInteraction000542432
WBInteraction000542436
WBInteraction000542440
WBInteraction000555811
GeneticsInterpolated_map_positionI2.09867
DescriptionPhenotypeWBPhenotype:0000004Paper_evidenceWBPaper00050796
Curator_confirmedWBPerson2987
Remark"We evaluated this question by crossing the grk-2(gk268) and grk-2(rt97) alleles with strains that are constitutive egg layers. These strains include a gain-of-function strain that has activated Gαq (egl-30(ep271)) as well as loss-of-function strains that are defective in Gαo (goa-1(n1134)), the G protein that inhibits egg laying; EAT-16 (eat-16(ep273)), the regulator of G protein signaling (RGS) protein of Gαq; or diacylglycerol kinase (dgk-1(sy428)), a potential effector enzyme that phosphorylates diacylglycerol." (Figure 3A)Paper_evidenceWBPaper00050796
Curator_confirmedWBPerson2987
Variation_effectLoss_of_function_undetermined_extentPaper_evidenceWBPaper00050796
Curator_confirmedWBPerson2987
EQ_annotationsGO_termGO:0018991PATO:0002356Paper_evidenceWBPaper00050796
Curator_confirmedWBPerson2987
WBPhenotype:0000005Paper_evidenceWBPaper00031438
Curator_confirmedWBPerson2369
WBPhenotype:0000105Paper_evidenceWBPaper00027739
Curator_confirmedWBPerson2021
RemarkOocytes in mutant females exhibit increased meiotic maturation rates in the absence of spermPaper_evidenceWBPaper00027739
Curator_confirmedWBPerson2021
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00027739
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006797PATO:0000460Paper_evidenceWBPaper00027739
Curator_confirmedWBPerson2021
Life_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00027739
Curator_confirmedWBPerson2021
Phenotype_assayGenotypefog-3(q443)Paper_evidenceWBPaper00027739
Curator_confirmedWBPerson2021
WBPhenotype:0000384Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarksome axon guidance defects(?)Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000546Paper_evidenceWBPaper00004721
WBPaper00032201
Curator_confirmedWBPerson712
RemarkAnimals laid more embryos in the one- to eight-cell stage than at the normal 21-cell stage.Paper_evidenceWBPaper00032201
Curator_confirmedWBPerson712
PenetranceComplete100% eggs laid are early (e.g. 8 or fewer cells.) (n=38)Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00004721
WBPaper00032201
Curator_confirmedWBPerson712
WBPhenotype:0000641Paper_evidenceWBPaper00004721
WBPaper00041213
Curator_confirmedWBPerson712
WBPerson461
RemarkDispersal index in the absence of anesthetic ~0.96 was increased compared to N2 ~0.90.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
The locomotion rates of goa-1(n1134) mutants were more variable than those of wild-type animals; goa-1(n1134) mutants achieve greater peak acceleration, resulting in large fluctuations in the speed within tracks.Paper_evidenceWBPaper00041213
Curator_confirmedWBPerson461
Phenotype_assayTreatmentDispersal assay as reported in Crowder et al.1996; van Swinderen et al. 1997.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0000642Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkHomozygous animals are hyperactive as assayed by an increase in the number of body bends/min, ~29.9 (n=28) vs. N2 ~24.9 (n=26)Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0001066Paper_evidenceWBPaper00003951
Curator_confirmedWBPerson2021
RemarkInactive phase was substantially shorter in goa-1 recessive mutant animals than in wild typePaper_evidenceWBPaper00003951
Curator_confirmedWBPerson2021
RecessivePaper_evidenceWBPaper00003951
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00003951
Curator_confirmedWBPerson2021
WBPhenotype:0001506Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals exhibit an significant increase in spontaneous reversals (~3.5 backward movements initiated/minute over 2 minutes) (n=28). n1134/+ animals do not exhibit a significant increase in reversals.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0001619Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals exhibit an EC50 of ~1.29 for isoflurane, whereas N2 has an EC50 of ~0.75 vol% as determined by a concentration-response curve based on animal dispersal indexes.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004563Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Phenotype_assayTreatmentDispersal assay followed the protocol reported in Crowder et al. 1996 and van Swinderen et al. 1997.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0001618Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals exhibit an EC50 of ~0.47 for halothane, similar to N2 (EC50 ~0.42), as determined by a concentration-response curve based on animal dispersal indexes.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001705Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Phenotype_assayTreatmentDispersal assay followed the protocol reported in Crowder et al. 1996 and van Swinderen et al. 1997.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0002055Paper_evidenceWBPaper00036207
Curator_confirmedWBPerson712
RemarkPhotocurrents appeared to be normal.Paper_evidenceWBPaper00036207
Curator_confirmedWBPerson712
Reference (16)
MethodSubstitution_allele