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WormBase Tree Display for Variation: WBVar00089873

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WBVar00089873	Name	Public_name	n997
	Sequence_details	SeqStatus	Pending_curation
	Variation_type	Allele
	Origin	Species	Caenorhabditis elegans
		Strain	WBStrain00027008
			WBStrain00027009
			WBStrain00027071
		Laboratory	MT
		Status	Live
	Affects	Gene	WBGene00001207
	Genetics	Mapping_data	In_multi_point	844
				845
				1065
				1385
			In_pos_neg_data	3190
				3227
				3228
				3229
				3230
				3231
				3234
	Description	Phenotype	WBPhenotype:0000006	Paper_evidence	WBPaper00001133
					WBPaper00001105
				Curator_confirmed	WBPerson2021
				Penetrance	High		Paper_evidence	WBPaper00001133
								WBPaper00001105
							Curator_confirmed	WBPerson2021
					Range	90	90	Paper_evidence	WBPaper00001133
									WBPaper00001105
								Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001133
					Curator_confirmed	WBPerson2021
				Variation_effect	Hypomorph_reduction_of_function	Paper_evidence	WBPaper00001133
						Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000057	PATO:0000460	Paper_evidence	WBPaper00001133
									WBPaper00001105
								Curator_confirmed	WBPerson2021
				Phenotype_assay	Temperature	20	Paper_evidence	WBPaper00001133
							Curator_confirmed	WBPerson2021
			WBPhenotype:0000339	Person_evidence	WBPerson261
				Curator_confirmed	WBPerson712
				Remark	Moderate bloating. Difficult to score (ES2) in adult, very hard to score (ES1) in other stages.	Person_evidence	WBPerson261
						Curator_confirmed	WBPerson712
				Ease_of_scoring	ES2_Difficult_to_score	Person_evidence	WBPerson261
						Curator_confirmed	WBPerson712
			WBPhenotype:0000425	Paper_evidence	WBPaper00001105
				Curator_confirmed	WBPerson2021
				Remark	Serotonin levels are reduced in HSNs (determined immunocytochemically).	Paper_evidence	WBPaper00001105
						Curator_confirmed	WBPerson2021
				EQ_annotations	Anatomy_term	WBbt:0006830	PATO:0000460	Paper_evidence	WBPaper00001105
								Curator_confirmed	WBPerson2021
					Life_stage	WBls:0000057	PATO:0000460	Paper_evidence	WBPaper00001105
								Curator_confirmed	WBPerson2021
			WBPhenotype:0000470	Paper_evidence	WBPaper00001105
				Person_evidence	WBPerson261
				Curator_confirmed	WBPerson2021
					WBPerson712
				Remark	HSNs fail to arrive at their final destination (between P5/6 and V4)	Paper_evidence	WBPaper00001105
						Curator_confirmed	WBPerson2021
					HSN cell bodies serotonin-positive but misplaced posteriorly along path of HSN migration	Person_evidence	WBPerson261
						Curator_confirmed	WBPerson712
				EQ_annotations	Anatomy_term	WBbt:0006830	PATO:0000460	Paper_evidence	WBPaper00001105
								Person_evidence	WBPerson261
								Curator_confirmed	WBPerson2021
									WBPerson712
					Life_stage	WBls:0000024	PATO:0000460	Paper_evidence	WBPaper00001105
								Curator_confirmed	WBPerson2021
			WBPhenotype:0000816	Person_evidence	WBPerson261
				Curator_confirmed	WBPerson712
				Remark	aberrant variable HSN processes, abnormal IL2 wiring.	Person_evidence	WBPerson261
						Curator_confirmed	WBPerson712
				EQ_annotations	Anatomy_term	WBbt:0006830	PATO:0000460	Person_evidence	WBPerson261
								Curator_confirmed	WBPerson712
						WBbt:0005118	PATO:0000460	Person_evidence	WBPerson261
								Curator_confirmed	WBPerson712
			WBPhenotype:0000843	Paper_evidence	WBPaper00001133
				Curator_confirmed	WBPerson2021
				Remark	males mate poorly (mating efficiency is 50 percent)	Paper_evidence	WBPaper00001133
						Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001133
					Curator_confirmed	WBPerson2021
				Variation_effect	Hypomorph_reduction_of_function	Paper_evidence	WBPaper00001133
						Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000056	PATO:0000460	Paper_evidence	WBPaper00001133
								Curator_confirmed	WBPerson2021
			WBPhenotype:0001340	Paper_evidence	WBPaper00001133
				Person_evidence	WBPerson261
				Curator_confirmed	WBPerson2021
					WBPerson712
				Remark	See Table 1	Paper_evidence	WBPaper00001133
						Curator_confirmed	WBPerson2021
					not stimulated by imipramine	Person_evidence	WBPerson261
						Curator_confirmed	WBPerson712
				Penetrance	High		Paper_evidence	WBPaper00001133
							Curator_confirmed	WBPerson2021
					Range	89	89	Paper_evidence	WBPaper00001133
								Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001133
					Curator_confirmed	WBPerson2021
				Variation_effect	Hypomorph_reduction_of_function	Paper_evidence	WBPaper00001133
						Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000057	PATO:0000460	Paper_evidence	WBPaper00001133
								Curator_confirmed	WBPerson2021
				Phenotype_assay	Treatment	0.75 mg/ml imipramine	Paper_evidence	WBPaper00001133
							Curator_confirmed	WBPerson2021
					Temperature	24	Paper_evidence	WBPaper00001133
							Curator_confirmed	WBPerson2021
		Phenotype_not_observed	WBPhenotype:0001068	Paper_evidence	WBPaper00001133
				Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001133
					Curator_confirmed	WBPerson2021
				Variation_effect	Hypomorph_reduction_of_function	Paper_evidence	WBPaper00001133
						Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000057	PATO:0000460	Paper_evidence	WBPaper00001133
								Curator_confirmed	WBPerson2021
				Phenotype_assay	Treatment	7.5 mg/ml serotonin	Paper_evidence	WBPaper00001133
							Curator_confirmed	WBPerson2021
					Temperature	24	Paper_evidence	WBPaper00001133
							Curator_confirmed	WBPerson2021
			WBPhenotype:0001629	Person_evidence	WBPerson261
				Curator_confirmed	WBPerson712
				Remark	stimulated by serotonin	Person_evidence	WBPerson261
						Curator_confirmed	WBPerson712
	Reference	WBPaper00016320
		WBPaper00016216
		WBPaper00001105
		WBPaper00001133
		WBPaper00016261
	Method	Allele