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WormBase Tree Display for Variation: WBVar00089862

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Name Class

WBVar00089862NamePublic_namen986
Other_namen987Paper_evidenceWBPaper00003631
n2164Paper_evidenceWBPaper00003631
Sequence_detailsSMapS_parentSequenceVF23B12L
Flanking_sequencesTTTTATTGGGTATTGTTTACTCCTAACCGGTGGTCCATAAAATTCTATTGTCCCAGATTT
Mapping_targetVF23B12L
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00003631
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00027000
WBStrain00027011
WBStrain00027054
LaboratoryMT
StatusLive
AffectsGeneWBGene00001170
InteractorWBInteraction000586831
GeneticsInterpolated_map_positionV6.30574
Mapping_dataIn_multi_point941
2264
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
RemarkThe penetrance of the egg-laying defect in ced-3(n717)/+ ; n986/+ heterozygotes is heat- sensitive.Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
PenetranceHighAs shown in Table 5, 99 percent of heterozygotes are Egl. Under homozygous conditions, 100 percent of hermaphrodites are EglPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
DominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
WBPhenotype:0000154Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
RemarkMutants show a 40 percent drop in brood size (compared to wild-type)Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
DominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
WBPhenotype:0000207Paper_evidenceWBPaper00056479
Curator_confirmedWBPerson712
RemarkSurprisingly, animals bearing two independent egl-1(dm) mutants that cause the HSNs to undergo premature cell death showed a decrease in DMP frequency (Figure 1B).Paper_evidenceWBPaper00056479
Curator_confirmedWBPerson712
WBPhenotype:0000339Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkstronger, non-ts allele than n487Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001172Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkstronger, non-ts allele than n487Person_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001220Paper_evidenceWBPaper00001133
WBPaper00001105
Curator_confirmedWBPerson2021
RemarkHSNs (which normally undergo apoptosis only in males) die in the mutant hermaphrodites. Authors comment it seems likely that egl-1 mutations cause the cell-specific sexual transformation of hermaphrodite HSNs.Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
HSNs undergo embryonic apoptosis in hermaphrodites.Paper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
DominantPaper_evidenceWBPaper00001133
WBPaper00001105
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00001133
WBPaper00001105
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0001340Paper_evidenceWBPaper00001133
Person_evidenceWBPerson261
Curator_confirmedWBPerson2021
WBPerson712
RemarkSee Table 1Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
stronger, non-ts allele than n487Person_evidenceWBPerson261
Curator_confirmedWBPerson712
PenetranceHighPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Range8383Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
DominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTreatment0.75 mg/ml imipraminePaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Temperature24Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
WBPhenotype:0001818Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
RemarkVC neurons were largely inactive, even under low-osmolarity conditions.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005304PATO:0000460Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested in low or high osmolarity. Animals were assayed 24 hr after the late fourth larval (L4) stage at 20.5C 0.5C.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
GenotypeCameleon IjIs25[myo-3::YC2.0]Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0001068Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
DominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTreatment7.5 mg/ml serotoninPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Temperature24Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
WBPhenotype:0001073Paper_evidenceWBPaper00003951
Curator_confirmedWBPerson2021
RemarkEgg-laying behavior in egl-1 mutants was strongly regulated by foodPaper_evidenceWBPaper00003951
Curator_confirmedWBPerson2021
WBPhenotype:0001629Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkstronger, non-ts allele than n487Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001816Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
RemarkVC activity was observed to be temporally coupled with egg laying events.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested in the presence of 50ul 10mg/ml serotonin in M9 to stimulate egg laying. Combined fluorescent and visible microscopy was used to view both the Ca2+ signal and egg laying events simultaneously. Animals were assayed 24 hr after the late fourth larval (L4) stage at 20.5C 0.5C.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
GenotypeCameleon IjIs25[myo-3::YC2.0]Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
ReferenceWBPaper00032221
WBPaper00020957
WBPaper00013864
WBPaper00003951
WBPaper00014768
WBPaper00001105
WBPaper00001133
WBPaper00056479
WBPaper00003631
MethodSubstitution_allele