Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00089691

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00089691EvidencePaper_evidenceWBPaper00001768
NamePublic_namen709
Other_nameC07H6.7.2:c.-1G>A
C07H6.7.1:c.1-1G>A
HGVSgCHROMOSOME_III:g.7534701C>T
Sequence_detailsSMapS_parentSequenceC07H6
Flanking_sequencestatcaatcactttcactcgttttcactccaatgaccacatcaacatcaccgtcatccaca
Mapping_targetC07H6
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00001768
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00026857
LaboratoryMT
StatusLive
AffectsGeneWBGene00003024
TranscriptC07H6.7.2VEP_consequence5_prime_UTR_variant
VEP_impactMODIFIER
HGVScC07H6.7.2:c.-1G>A
cDNA_position105
Exon_number1/7
C07H6.7.1VEP_consequencesplice_acceptor_variant
VEP_impactHIGH
HGVScC07H6.7.1:c.1-1G>A
Intron_number1/6
InteractorWBInteraction000002755
WBInteraction000002764
WBInteraction000500077
WBInteraction000500078
WBInteraction000521976
WBInteraction000535543
WBInteraction000535544
GeneticsInterpolated_map_positionIII-0.673654
DescriptionPhenotypeWBPhenotype:0000099Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkSome or all P3.aap - P8.aap (presumptive VC neurons) die in hermaphrodites, very hard to score (ES1).Person_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005304PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES1_Very_hard_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000216Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkMultiple defects in specification of fates in mid-body.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000219Paper_evidenceWBPaper00005344
WBPaper00005277
Curator_confirmedWBPerson2987
RemarkThe lin-39(n709) mutation resulted in fewer than the expected number of induced vulval precursor cells (2.58 on average instead of 3.0 in wild type)Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
Table 3Paper_evidenceWBPaper00005277
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0007809PATO:0000460Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
WBPhenotype:0000239Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkVariably abnormal vulval divisions.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000324Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000542Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000640Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkVariably Egl, difficult to score (ES2).Person_evidenceWBPerson261
Curator_confirmedWBPerson712
PenetranceIncompletePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES2_Difficult_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000698Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
RemarkThe lin-39(n709) mutation resulted in a vulvaless phenotype in 56% of animalsPaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
PenetranceIncompletePaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006748PATO:0000460Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
WBPhenotype:0001278Paper_evidenceWBPaper00005609
Curator_confirmedWBPerson712
Remark76% (n=160) of unfused P5.p-P7.p cells in lin-39(+) worms expressed elt-18/elt-6::GFP, only 42% (n=85) did so in animals carrying n709.Paper_evidenceWBPaper00005609
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00005609
Curator_confirmedWBPerson712
WBPhenotype:0001818Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
RemarkHSN neurons showed increased activity, as demonstrated by increased calcium spike frequency compared to wild-type animals, even in conditions of high-osmolarity.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were tested in low or high osmolarity. Animals were assayed 24 hr after the late fourth larval (L4) stage at 20.5C 0.5C.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
GenotypeCameleon IjIs25[myo-3::YC2.0]Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
WBPhenotype:0002284Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002287Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002290Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002292Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002299Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002302Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002314Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002319Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002344Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004023Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000099Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
RemarkThe lin-39(n709) mutation did not induce the "2 P11.p" phenotype where the P12 cell adopts a P11 cell fatePaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
WBPhenotype:0001816Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
RemarkEgg-laying events were still strongly correlated with HSN activity.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
Phenotype_assayTreatmentCombined fluorescent and visible microscopy was used to view both the Ca2+ signal and egg-laying events simultaneously. Animals were assayed 24 hr after the late fourth larval (L4) stage at 20.5C 0.5C.Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
GenotypeCameleon IjIs25[myo-3::YC2.0]Paper_evidenceWBPaper00032221
Curator_confirmedWBPerson712
ReferenceWBPaper00043908
WBPaper00005277
WBPaper00005344
WBPaper00016118
WBPaper00014076
WBPaper00032221
WBPaper00016177
WBPaper00015250
WBPaper00005609
MethodSubstitution_allele