Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Variation: WBVar00089452

expand all nodes | collapse all nodes | view schema

Name Class

WBVar00089452NamePublic_namen363
Sequence_detailsSeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00026725
LaboratoryMT
StatusLive
AffectsGeneWBGene00001648
InteractorWBInteraction000524572
DescriptionPhenotype (11)
Phenotype_not_observedWBPhenotype:0000481Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Remarkgoa-1(n363) mutants exhibited a wild type avoidance response to high osmotic strength (1 molar glycerol) compared to wild type controls (Figure 2a).Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
goa-1(n363) mutants exhibited a wild type avoidance response to 10 millimolar quinine compared to wild type controls (Figure 2a).Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003633Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBMol:00003904Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
WBPhenotype:0000680Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals were not blocked in halothane induced aldicarb resistance, except at very high concentrations of the volatile anesthetic as observed in WT.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001705Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBMol:00003650Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0001182Paper_evidenceWBPaper00032082
Curator_confirmedWBPerson712
RemarkFat levels were similar to that seen in wild-type but are reduced when compared to daf-7(e1375) as determined by Sudan Black assay (described in Kimura et al., 1997).Paper_evidenceWBPaper00032082
Curator_confirmedWBPerson712
Phenotype_assayTreatmentTo minimize staining variability, which allowed for quantitative comparisons between various genotypes: animals from one genotype were labeled with fluorescein isothiocyanate (FITC) and then fixed and stained in the same tube as unlabeled animals from another genotype.Paper_evidenceWBPaper00032082
Curator_confirmedWBPerson712
Temperature22Paper_evidenceWBPaper00032082
Curator_confirmedWBPerson712
WBPhenotype:0001612Paper_evidenceWBPaper00006275
Curator_confirmedWBPerson712
RemarkMean egg-laying frequency decreased as observed for N2 animals when treated with ethanol.Paper_evidenceWBPaper00006275
Curator_confirmedWBPerson712
WBPhenotype:0001618Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
RemarkAnimals exhibit an EC50 of ~0.48 for halothane, similar to N2 (EC50 ~0.42) vol%, as determined by a concentration-response curve based on animal dispersal indexes.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001705Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
Phenotype_assayTreatmentDispersal assay followed the protocol reported in Crowder et al. 1996 and van Swinderen et al. 1997.Paper_evidenceWBPaper00004721
Curator_confirmedWBPerson712
WBPhenotype:0002199Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
RemarkThe goa-1(n363) mutation did not affect the calcium transients in ASH neurons in response to high osmolarity (1M glycerol) (Figure 4a)Paper_evidenceWBPaper00037778
Curator_confirmedWBPerson2987
Disease_infoModels_diseaseDOID:0050709
Models_disease_in_annotationWBDOannot00001090
Reference (12)
MethodAllele