WormBase Tree Display for Variation: WBVar00089409

WBVar00089409 Name: Public_name: n309
  Sequence_details: SMap: S_parent: Sequence: CHROMOSOME_X
    SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00007520
      WBStrain00026720
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00023497
      WBGene00023498
    Interactor: WBInteraction000052344
      WBInteraction000502381
      WBInteraction000524058
      WBInteraction000556891
      WBInteraction000556892
      WBInteraction000563586
  Genetics: Mapping_data: In_2_point: 6060
        7015
      In_multi_point: 411
        2472
        2473
        2474
        2475
      In_pos_neg_data: 491
        518
        519
        536
  Description: Phenotype: WBPhenotype:0000099 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Remark: The lin-15(n309) mutation resulted in 33% of animals with the '0 P11.p' phenotype (P11 adopts a P12 fate). No animals exhibited the '2 P11.p' phenotype (P12 adopts a P11 fate). Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Penetrance: Incomplete: Paper_evidence: WBPaper00005344
              Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0004410 PATO:0000460 Paper_evidence: WBPaper00005344
                Curator_confirmed: WBPerson2987
            WBbt:0004409 PATO:0000460 Paper_evidence: WBPaper00005344
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000218 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Remark: The lin-15(n309) mutation resulted in more than the expected number of induced vulval precursor cells (5.82 on average instead of 3.0 in wild type) Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0007809 PATO:0000460 Paper_evidence: WBPaper00005344
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000453 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Adult males have one to three ventral protrusions, rudimentary ectopic hook. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          Adult males have one to three ventral protrusions, rudimentary ectopic hook. ME0. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
      WBPhenotype:0000700 Paper_evidence: WBPaper00000762
          WBPaper00005344
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson2021
          WBPerson712
          WBPerson2987
        Remark: 2 or 3 large ventral protrusions Paper_evidence: WBPaper00000762
            Curator_confirmed: WBPerson2021
          adult hermaphrodite Muv, vulva either normal or nonfunctional, two to six ventral protrusions. Some animals rupture during L4 molt. Possibly enhanced phenotype in n309/Df Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          100% of lin-15(n309) animals have multiple vulva Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Penetrance: Complete: Paper_evidence: WBPaper00005344
              Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00000762
          Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00005344
                Curator_confirmed: WBPerson2987
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00000762
                Person_evidence: WBPerson261
                Curator_confirmed: WBPerson2021
                  WBPerson712
            WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00000762
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: him-5(e1467) Paper_evidence: WBPaper00000762
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000805 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Adult males have a rudimentary ectopic hook. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Person_evidence: WBPerson261
                Curator_confirmed: WBPerson712
        Ease_of_scoring: ES0_Impossible_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001414 Paper_evidence: WBPaper00000762
        Curator_confirmed: WBPerson2021
        Remark: male mating is completely abolished Paper_evidence: WBPaper00000762
            Curator_confirmed: WBPerson2021
        Penetrance: High: Paper_evidence: WBPaper00000762
              Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000762
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000056 PATO:0000460 Paper_evidence: WBPaper00000762
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: him-5(e1467) Paper_evidence: WBPaper00000762
              Curator_confirmed: WBPerson2021
      WBPhenotype:0002464 Paper_evidence: WBPaper00045644
        Curator_confirmed: WBPerson625
        Remark: the phenotype is cell fate specification defect in which there is an extra hook secondary lineage, basically multiHook Paper_evidence: WBPaper00045644
            Curator_confirmed: WBPerson625
        EQ_annotations: Anatomy_term: WBbt:0008425 PATO:0000460 Paper_evidence: WBPaper00045644
                Curator_confirmed: WBPerson625
          GO_term: GO:0001708 PATO:0000460 Paper_evidence: WBPaper00045644
                Curator_confirmed: WBPerson625
    Phenotype_not_observed: WBPhenotype:0000698 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
  Reference (24)
  Remark: The left breakpoint lies somewhere between the second XhoI site and the EcoRI site. The right breakpoint is either close to the BamHI site or to the right of it; the precise location was unable to be determined because of we were repetitive DNA to the left of the BamHI site. See fig 8. Paper_evidence: WBPaper00002345
  Method: Deletion_allele