WormBase Tree Display for Variation: WBVar00089405

WBVar00089405 Name: Public_name: n304
  Sequence_details: Mapping_target: C37F5
    SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00027312
      WBStrain00027318
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00002990
    Interactor: WBInteraction000502207
      WBInteraction000504880
      WBInteraction000518964
      WBInteraction000524050
      WBInteraction000524051
      WBInteraction000524052
      WBInteraction000524053
      WBInteraction000524054
      WBInteraction000542279
  Description: Phenotype: WBPhenotype:0000054 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Remark: lin-1(n304) results in 3% rod-like larval lethality Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Penetrance: Low: Paper_evidence: WBPaper00005344
              Curator_confirmed: WBPerson2987
        Variation_effect: Null: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Lethality was scored in animals segregating from homozygous mothers. Paper_evidence: WBPaper00005344
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000218 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Remark: The lin-1(n304) mutation resulted in more than the expected number of induced vulval precursor cells (5.16 on average instead of 3.0 in wild type) Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Variation_effect: Null: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0007809 PATO:0000460 Paper_evidence: WBPaper00005344
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Vulval and P11.p phenotypes were scored in animals segregating from lin-1(e1275) unc-24/lin-1(e1275)+ or lin-1(n304)/DnT1 mothers. Paper_evidence: WBPaper00005344
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000220 Paper_evidence: WBPaper00003200
        Curator_confirmed: WBPerson2987
        Remark: Vulval precursor cells are defective in the specification of the primary, secondary and tertiary cell fates during the L3 stage (Table 1). Paper_evidence: WBPaper00003200
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0007809 PATO:0000460 Paper_evidence: WBPaper00003200
                Curator_confirmed: WBPerson2987
          Life_stage: WBls:0000035 PATO:0000460 Paper_evidence: WBPaper00003200
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000700 Paper_evidence: WBPaper00000762
          WBPaper00005344
          WBPaper00003200
        Curator_confirmed: WBPerson2021
          WBPerson2987
        Remark: 100% of lin-1(n304) animals have multiple vulva Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
          Table 1 Paper_evidence: WBPaper00003200
            Curator_confirmed: WBPerson2987
        Penetrance: Complete: Paper_evidence: WBPaper00005344
                WBPaper00003200
              Curator_confirmed: WBPerson2987
        Recessive: Paper_evidence: WBPaper00000762
          Curator_confirmed: WBPerson2021
        Variation_effect: Null: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006748 PATO:0000460 Paper_evidence: WBPaper00005344
                  WBPaper00003200
                Curator_confirmed: WBPerson2987
          Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00000762
                Curator_confirmed: WBPerson2021
            WBls:0000035 PATO:0000460 Paper_evidence: WBPaper00003200
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Vulval and P11.p phenotypes were scored in animals segregating from lin-1(e1275) unc-24/lin-1(e1275)+ or lin-1(n304)/DnT1 mothers. Paper_evidence: WBPaper00005344
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000961 Paper_evidence: WBPaper00038408
        Curator_confirmed: WBPerson712
        Remark: strong and uniform derepression was observed of lag-2 in all six VPCs in lin-1(0) mutants; arEx1098[lag-2p(min)::2nls-yfp::unc-54 3'UTR] and arIs131[lag-2p::2nls-yfp::unc-54 3'UTR] are uniformly expressed in all VPCs. Paper_evidence: WBPaper00038408
            Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000099 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Remark: The lin-1(n304) mutation did not result in any animals with the '0 P11.p' phenotype (P11 adopts a P12 fate) or the '2 P11.p' phenotype (P12 adopts a P11 fate) Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Variation_effect: Null: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Vulval and P11.p phenotypes were scored in animals segregating from lin-1(e1275) unc-24/lin-1(e1275)+ or lin-1(n304)/DnT1 mothers. Paper_evidence: WBPaper00005344
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000698 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Variation_effect: Null: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Vulval and P11.p phenotypes were scored in animals segregating from lin-1(e1275) unc-24/lin-1(e1275)+ or lin-1(n304)/DnT1 mothers. Paper_evidence: WBPaper00005344
              Curator_confirmed: WBPerson2987
      WBPhenotype:0001426 Paper_evidence: WBPaper00004883
        Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: arIs37 Paper_evidence: WBPaper00004883
              Curator_confirmed: WBPerson712
  Reference: WBPaper00038408
    WBPaper00003200
    WBPaper00005344
    WBPaper00004883
    WBPaper00000762
    WBPaper00014894
  Remark: Exons 4 and 5 are deleted and exons 5 and 6 are rearranged. Paper_evidence: WBPaper00024367
  Method: Allele