WormBase Tree Display for Variation: WBVar00089401

WBVar00089401 Evidence: Paper_evidence: WBPaper00004442
  Name: Public_name: n301
    Other_name: K10G6.1.1:c.185G>A
      CE12098:p.Arg62Gln
    HGVSg: CHROMOSOME_II:g.3983472G>A
  Sequence_details: SMap: S_parent: Sequence: K10G6
    Flanking_sequences: gtaatgttttcaggtggcaaaactccctgc acacaacttgtcattcaacgactgcttcat
    Mapping_target: K10G6
    Type_of_mutation: Substitution: g a
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain (15)
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00003017
    Transcript: K10G6.1.1 (12)
    Interactor: WBInteraction000052119
      WBInteraction000500693
      WBInteraction000500697
      WBInteraction000501874
      WBInteraction000524414
  Isolation: Mutagen: EMS
  Genetics: Interpolated_map_position: II -5.88214
    Mapping_data: In_2_point: 783
        784
      In_multi_point (14)
      In_pos_neg_data (13)
  Description: Phenotype (10)
    Phenotype_not_observed: WBPhenotype:0000054 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Variation_effect: Null: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
      WBPhenotype:0000099 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Remark: The lin-31(n301) mutation did not result in any animals with the '0 P11.p' phenotype (P11 adopts a P12 fate) or the '2 P11.p' phenotype (P12 adopts a P11 fate) Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Variation_effect: Null: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
      WBPhenotype:0000170 Paper_evidence: WBPaper00026707
        Curator_confirmed: WBPerson712
      WBPhenotype:0000640 Paper_evidence: WBPaper00026707
        Curator_confirmed: WBPerson712
        Penetrance: Low: <1% (n=337) Paper_evidence: WBPaper00026707
              Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00026863
        Curator_confirmed: WBPerson712
        Remark: 0% animals produced progeny (n=33). Paper_evidence: WBPaper00026863
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: All strains were grown at 20C. Paper_evidence: WBPaper00026863
              Curator_confirmed: WBPerson712
      WBPhenotype:0000961 Paper_evidence: WBPaper00038408
          WBPaper00004481
        Curator_confirmed: WBPerson712
          WBPerson2987
        Remark: arIs131[lag-2p::2Xnls::yfp] is expressed specifically in P6.p in a lin-31(0) null mutant, as in wild type; arIs131[lag-2p::2nls-yfp::unc-54 3'UTR] expression remains P6.p specific. Paper_evidence: WBPaper00038408
            Curator_confirmed: WBPerson712
          "In a lin-31 mutant background, VPCs adopt vulval or non-vulval fates randomly, although P6.p is always the closest VPC to the AC. We scored the patterning of P6.p descendants only when P6.p adopted the 1&deg; fate (scored according to detachment of the descendants from ventral cuticle and symmetry of invagination; Katz et al., 1995), and found that it displayed the wild-type zmp-1::GFP expression pattern in its progeny in all cases (n=31 animals, Table 5). Therefore, lin-31 is likely not required during 1&deg; lineage patterning." Paper_evidence: WBPaper00004481
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0007809 PATO:0000460 Paper_evidence: WBPaper00004481
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: syIs49 [zmp-1::GFP] Paper_evidence: WBPaper00004481
              Curator_confirmed: WBPerson2987
      WBPhenotype:0001024 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Male gross morphology wildtype. Similar phenotype in n301/Df. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
  Reference (13)
  Method: Substitution_allele