WormBase Tree Display for Variation: WBVar00089286

WBVar00089286 Evidence: Paper_evidence: WBPaper00004977
  Name: Public_name: n150
    Other_name: n150ts
      CE45708:p.Gly469Glu
      CE08940:p.Gly594Glu
      C51E3.7c.1:c.1406G>A
      C51E3.7a.1:c.1781G>A
    HGVSg: CHROMOSOME_V:g.10170178C>T
  Sequence_details: SMap: S_parent: Sequence: C51E3
    Flanking_sequences: caacacacacatggggagagaatccaacag aaaatggagacttgtcgccagattccaagt
    Mapping_target: C51E3
    Type_of_mutation: Substitution: g a
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026704
      WBStrain00056259
    Laboratory: MT
      ZAS
    Status: Live
  Affects: Gene: WBGene00001172
    Transcript: C51E3.7a.1 (12)
      C51E3.7c.1 (12)
  Genetics: Interpolated_map_position: V 2.28547
    Mapping_data: In_2_point: 715
      In_multi_point: 329
        608
        609
        797
        953
      In_pos_neg_data: 1732
        1733
        1734
        1741
  Description: Phenotype: WBPhenotype:0000007 Paper_evidence: WBPaper00000635
        Curator_confirmed: WBPerson48
        Penetrance: Incomplete: Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
        Phenotype_assay: Temperature: 25 Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
      WBPhenotype:0000122 Paper_evidence: WBPaper00028958
        Curator_confirmed: WBPerson557
        Remark: Depletion of neuropeptides, presumably because EGL-3 is necessary for neuropeptide processing. Paper_evidence: WBPaper00028958
            Curator_confirmed: WBPerson557
      WBPhenotype:0000545 Paper_evidence: WBPaper00000635
        Curator_confirmed: WBPerson48
        Phenotype_assay: Temperature: 25 Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
      WBPhenotype:0000565 Paper_evidence: WBPaper00000635
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
        Remark: coiler phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0000640 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Easy to score (ES3) in adults at 25C. Difficult to score (ES2) in larvae and males. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000862 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: moderate bloating Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Temperature_sensitive: Heat_sensitive: 25 Person_evidence: WBPerson261
              Curator_confirmed: WBPerson712
      WBPhenotype:0001049 Paper_evidence: WBPaper00048845
        Curator_confirmed: WBPerson3990
        Remark: increased sensitivity in acidic pH avoidance Paper_evidence: WBPaper00048845
            Curator_confirmed: WBPerson3990
    Phenotype_not_observed: WBPhenotype:0001068 Paper_evidence: WBPaper00000635
        Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: 5 mg/ml serotonin Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
          Temperature: 25 Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
      WBPhenotype:0001340 Paper_evidence: WBPaper00000635
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
        Remark: stimulated by imipramine Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: 0.75 mg/ml imipramine Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
          Temperature: 25 Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
      WBPhenotype:0001629 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: stimulated by serotonin Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001765 Paper_evidence: WBPaper00031936
        Curator_confirmed: WBPerson2021
        Remark: Mutants defective in neuromodulation respond normally to CO2 Paper_evidence: WBPaper00031936
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00031936
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: 10% CO2 Paper_evidence: WBPaper00031936
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001780 Paper_evidence: WBPaper00029060
        Curator_confirmed: WBPerson2021
        Remark: Mutants show normal butanone enhancement Paper_evidence: WBPaper00029060
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00029060
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: Preexposure to 1:10 dilution of butanone and food. Animals were then subjected to odorant chemotaxis assays and/or selection assays Paper_evidence: WBPaper00029060
              Curator_confirmed: WBPerson2021
  Reference: WBPaper00031936
    WBPaper00000635
    WBPaper00029060
    WBPaper00028958
    WBPaper00048845
    WBPaper00065754
  Method: Substitution_allele